Search Results - "Forton, Julian"

Future therapies for cystic fibrosis by Allen, Lucy, Allen, Lorna, Carr, Siobhan B., Davies, Gwyneth, Downey, Damian, Egan, Marie, Forton, Julian T., Gray, Robert, Haworth, Charles, Horsley, Alexander, Smyth, Alan R., Southern, Kevin W., Davies, Jane C.

“…We are currently witnessing transformative change for people with cystic fibrosis with the introduction of small molecule, mutation-specific drugs capable of…”
Get full text

Pathogen detection. The bread and butter by Forton, Julian T.

Get full text

Detecting respiratory infection in children with cystic fibrosis: Cough swab, sputum induction or bronchoalveolar lavage by Forton, Julian T.

“…Young children with cystic fibrosis (CF) are generally very well, cough free and non-productive, and are often incapable of spontaneously expectorating sputum…”
Get full text

The CF-Sputum Induction Trial (CF-SpIT) to assess lower airway bacterial sampling in young children with cystic fibrosis: a prospective internally controlled interventional trial by Ronchetti, Katherine, Tame, Jo-Dee, Paisey, Christopher, Thia, Lena P, Doull, Iolo, Howe, Robin, Mahenthiralingam, Eshwar, Forton, Julian T

“…Pathogen surveillance is challenging but crucial in children with cystic fibrosis—who are often non-productive of sputum even if actively coughing—because…”
Get full text

The fungal diversity in the lungs of children with cystic fibrosis captured by sputum-induction and bronchoalveolar lavage by Weiser, Rebecca, Ronchetti, Katherine, Tame, Jo-Dee, Hoehn, Sven, Jurkowski, Tomasz P, Mahenthiralingam, Eshwar, Forton, Julian T

“…The prevalence of fungi in cystic fibrosis (CF) lung infections is poorly understood and studies have focused on adult patients. We investigated the fungal…”
Get full text

Cystic fibrosis newborn screening: the importance of bloodspot sample quality by Doull, Iolo, Course, Christopher William, Hanks, Ruth E, Southern, Kevin W, Forton, Julian T, Thia, Lena P, Moat, Stuart J

“…ObjectiveWales has an immunoreactive trypsin (IRT)-DNA cystic fibrosis (CF) newborn screening (NBS) programme. Most CF NBS false negative cases are due to an…”
Get full text

The lung microbiota in children with cystic fibrosis captured by induced sputum sampling by Weiser, Rebecca, Oakley, Juliette, Ronchetti, Katherine, Tame, Jo-Dee, Hoehn, Sven, Jurkowski, Tomasz P., Mahenthiralingam, Eshwar, Forton, Julian T.

“…•Bronchoalveolar lavage (BAL) and induced sputum (IS) samples were investigated.•Microbiota compartmentalisation of the lower airway occurs in children with…”
Get full text

Differential susceptibility of Dectin‐1 isoforms to functional inactivation by neutrophil and fungal proteases by Griffiths, James S., Thompson, Aiysha, Stott, Matthew, Benny, Ankita, Lewis, Natalie A., Taylor, Philip R., Forton, Julian, Herrick, Sarah, Orr, Selinda J., McGreal, Eamon P.

“…ABSTRACT Patients with cystic fibrosis (CF) experience chronic or recurrent bacterial and fungal lung infections. Many patients with CF cannot effectively…”
Get full text

Six-lobe bronchoalveolar lavage in children with cystic fibrosis – Authors' reply by Forton, Julian T, Doull, Iolo, Thia, Lena P

Get full text

Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria by Fry, Andrew E., Griffiths, Michael J., Auburn, Sarah, Diakite, Mahamadou, Forton, Julian T., Green, Angela, Richardson, Anna, Wilson, Jonathan, Jallow, Muminatou, Sisay-Joof, Fatou, Pinder, Margaret, Peshu, Norbert, Williams, Thomas N., Marsh, Kevin, Molyneux, Malcolm E., Taylor, Terrie E., Rockett, Kirk A., Kwiatkowski, Dominic P.

“…There is growing epidemiological and molecular evidence that ABO blood group affects host susceptibility to severe Plasmodium falciparum infection. The high…”
Get full text

Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy by Oakley, Juliette L, Weiser, Rebecca, Powell, Lydia C, Forton, Julian, Mahenthiralingam, Eshwar, Rye, Philip D, Hill, Katja E, Thomas, David W, Pritchard, Manon F

“…Chronic lung infections in cystic fibrosis (CF) evolve to generate environmentally adapted biofilm communities, leading to increased patient morbidity and…”
Get full text

Localization of a long-range cis-regulatory element of IL13 by allelic transcript ratio mapping by Forton, Julian T, Udalova, Irina A, Campino, Susana, Rockett, Kirk A, Hull, Jeremy, Kwiatkowski, Dominic P

“…It appears that, for many genes, the two alleles possessed by an individual may produce different amounts of transcript. When such allelic differences in…”
Get full text

Validating discovered Cis-acting regulatory genetic variants: application of an allele specific expression approach to HapMap populations by Campino, Susana, Forton, Julian, Raj, Srilakshmi, Mohr, Bert, Auburn, Sarah, Fry, Andrew, Mangano, Valentina D, Vandiedonck, Claire, Richardson, Anna, Rockett, Kirk, Clark, Taane G, Kwiatkowski, Dominic P

“…Localising regulatory variants that control gene expression is a challenge for genome research. Several studies have recently identified non-coding…”
Get full text

Searching for the regulators of human gene expression by Forton, Julian T., Kwiatkowski, Dominic P.

“…Many common human traits are believed to be a composite reflection of multiple genetic and non‐genetic factors and the genetic contribution is consequently…”
Get full text

TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression by Campino, Susana, Forton, Julian, Auburn, Sarah, Fry, Andrew, Diakite, Mahamadou, Richardson, Anna, Hull, Jeremy, Jallow, Muminatou, Sisay-Joof, Fatou, Pinder, Margaret, Molyneux, Malcolm E, Taylor, Terrie E, Rockett, Kirk, Clark, Taane G, Kwiatkowski, Dominic P

“…During malaria infection the Toll-like receptor 9 (TLR9) is activated through induction with plasmodium DNA or another malaria motif not yet identified…”
Get full text

Induced sputum in young healthy children with cystic fibrosis by Forton, Julian

“…Summary Young children with CF are often asymptomatic and non-productive, yet CF lung disease occurs early in life. Cough swabs are used routinely to sample…”
Get full text

British Thoracic Society guideline for respiratory management of children with neuromuscular weakness by Hull, Jeremy, Aniapravan, Roona, Chan, Elaine, Chatwin, Michelle, Forton, Julian, Gallagher, Jayne, Gibson, Neil, Gordon, Jill, Hughes, Imelda, McCulloch, Renee, Russell, Robert Ross, Simonds, Anita

Get more information

Analysis of Neuropsychiatric Diagnoses After Montelukast Initiation by Paljarvi, Tapio, Forton, Julian, Luciano, Sierra, Herttua, Kimmo, Fazel, Seena

“…The evidence base for the association between montelukast and adverse neuropsychiatric outcomes is mixed and inconclusive. Several methodological limitations…”
Get full text

A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness by Pritchard, Manon F, Powell, Lydia C, Jack, Alison A, Powell, Kate, Beck, Konrad, Florance, Hannah, Forton, Julian, Rye, Philip D, Dessen, Arne, Hill, Katja E, Thomas, David W

“…In chronic respiratory disease, the formation of dense, 3-dimensional "microcolonies" by within the airway plays an important role in contributing to…”
Get full text

BTS clinical statement on aspiration pneumonia by Simpson, A John, Allen, Jamie-Leigh, Chatwin, Michelle, Crawford, Hannah, Elverson, Joanna, Ewan, Victoria, Forton, Julian, McMullan, Ronan, Plevris, John, Renton, Kate, Tedd, Hilary, Thomas, Rhys, Legg, Julian

Get more information