Search Results - "Fortner, Karen A."

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance by Giddings, Emily L., Champagne, Devin P., Wu, Meng-Han, Laffin, Joshua M., Thornton, Tina M., Valenca-Pereira, Felipe, Culp-Hill, Rachel, Fortner, Karen A., Romero, Natalia, East, James, Cao, Phoebe, Arias-Pulido, Hugo, Sidhu, Karatatiwant S., Silverstrim, Brian, Kam, Yoonseok, Kelley, Shana, Pereira, Mark, Bates, Susan E., Bunn, Janice Y., Fiering, Steven N., Matthews, Dwight E., Robey, Robert W., Stich, Domink, D’Alessandro, Angelo, Rincon, Mercedes

“…Chemotherapy remains the standard of care for most cancers worldwide, however development of chemoresistance due to the presence of the drug-effluxing ATP…”
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Fine-Tuning of CD8+ T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus by Champagne, Devin P., Hatle, Ketki M., Fortner, Karen A., D’Alessandro, Angelo, Thornton, Tina M., Yang, Rui, Torralba, Daniel, Tomás-Cortázar, Julen, Jun, Yong Woong, Ahn, Kyo Han, Hansen, Kirk C., Haynes, Laura, Anguita, Juan, Rincon, Mercedes

“…Mitochondrial respiration is regulated in CD8+ T cells during the transition from naive to effector and memory cells, but mechanisms controlling this process…”
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Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity by Hughes, Peter D., Belz, Gabrielle T., Fortner, Karen A., Budd, Ralph C., Strasser, Andreas, Bouillet, Philippe

“…Apoptotic death of T lymphocytes is critical for shutdown of immune responses and hemopoietic cell homeostasis. Both death receptor (Fas) activation and…”
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Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice by Fortner, Karen A, Blanco, Luz P, Buskiewicz, Iwona, Huang, Nick, Gibson, Pamela C, Cook, Deborah L, Pedersen, Hege L, Yuen, Peter S T, Murphy, Michael P, Perl, Andreas, Kaplan, Mariana J, Budd, Ralph C

“…ObjectivesRecent investigations in humans and mouse models with lupus have revealed evidence of mitochondrial dysfunction and production of mitochondrial…”
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Protein disulfide isomerase–endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness by Hoffman, Sidra M., MS, Chapman, David G., PhD, Lahue, Karolyn G., BS, Cahoon, Jonathon M., BA, Rattu, Gurkiranjit K, Daphtary, Nirav, MS, Aliyeva, Minara, MD, Fortner, Karen A., PhD, Erzurum, Serpil C., MD, Comhair, Suzy A.A., PhD, Woodruff, Prescott G., MD, MPH, Bhakta, Nirav, MD, Dixon, Anne E., MD, Irvin, Charles G., PhD, Janssen-Heininger, Yvonne M.W., PhD, Poynter, Matthew E., PhD, Anathy, Vikas, PhD

“…Background Evidence for association between asthma and the unfolded protein response is emerging. Endoplasmic reticulum resident protein 57 (ERp57) is an…”
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Acetate Supplementation as a Means of Inducing Glioblastoma Stem-Like Cell Growth Arrest by Long, Patrick M., Tighe, Scott W., Driscoll, Heather E., Fortner, Karen A., Viapiano, Mariano S., Jaworski, Diane M.

“…Glioblastoma (GBM), the most common primary adult malignant brain tumor, is associated with a poor prognosis due, in part, to tumor recurrence mediated by…”
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Glycolysis Induces MCJ Expression That Links T Cell Proliferation With Caspase-3 Activity and Death by Secinaro, Michael A, Fortner, Karen A, Collins, Cheryl, Rincón, Mercedes, Budd, Ralph C

“…An effective adaptive immune response requires rapid T cell proliferation, followed by equally robust cell death. These two processes are coordinately…”
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Reduced Immune Response to Borrelia burgdorferi in the Absence of γδ T Cells by CUIXIA SHI, SAHAY, Bikash, RUSSELL, Jennifer Q, FORTNER, Karen A, HARDIN, Nicholas, SELLATI, Timothy J, BUDD, Ralph C

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pregnancy Alters the Proliferation and Apoptosis of Mouse Splenic Erythroid Lineage Cells and Leukocytes by Norton, Michelle T, Fortner, Karen A, Bizargity, Peyman, Bonney, Elizabeth A

“…Pregnancy induces dynamic changes in the maternal environment that include reversible modifications in response to systemic mediators and local signals. The…”
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IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells by Yang, Rui, Masters, April R, Fortner, Karen A, Champagne, Devin P, Yanguas-Casás, Natalia, Silberger, Daniel J, Weaver, Casey T, Haynes, Laura, Rincon, Mercedes

“…IL-6 is known to contribute to the differentiation of CD4 T cells into different subsets of effector T helper cells. Less is known about the potential of IL-6…”
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Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation by Barbier-Torres, Lucía, Fortner, Karen A., Iruzubieta, Paula, Delgado, Teresa C., Giddings, Emily, Chen, Youdinghuan, Champagne, Devin, Fernández-Ramos, David, Mestre, Daniela, Gomez-Santos, Beatriz, Varela-Rey, Marta, de Juan, Virginia Gutiérrez, Fernández-Tussy, Pablo, Zubiete-Franco, Imanol, García-Monzón, Carmelo, González-Rodríguez, Águeda, Oza, Dhaval, Valença-Pereira, Felipe, Fang, Qian, Crespo, Javier, Aspichueta, Patricia, Tremblay, Frederic, Christensen, Brock C., Anguita, Juan, Martínez-Chantar, María Luz, Rincón, Mercedes

“…Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with an estimated 25% worldwide prevalence. No drugs have yet been…”
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c-FLIPS reduces activation of caspase and NF-κB pathways and decreases T cell survival by Hinshaw-Makepeace, Jennifer, Huston, Gail, Fortner, Karen A, Russell, Jennifer Q, Holoch, Daniel, Swain, Susan, Budd, Ralph C

“…Effective stimulation of NF-κB in T cells following TCR ligation requires the activity of caspase-8. The active caspase-8 complex includes the paracaspase,…”
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T Cell Homeostatic Proliferation Promotes a Redox State That Drives Metabolic and Epigenetic Upregulation of Inflammatory Pathways in Lupus by Budd, Ralph C, Scharer, Christopher D, Barrantes-Reynolds, Ramiro, Legunn, Scott, Fortner, Karen A

“…Numerous abnormalities in T cells have been described in patients with systemic lupus erythematosus (SLE), including lymphopenia, DNA demethylation, expression…”
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Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts by Fortner, Karen A, Lees, Rosemary K, MacDonald, H Robson, Budd, Ralph C

“…Fas-deficient mice (Fas(lpr/lpr)) and humans have profoundly dysregulated T lymphocyte homeostasis, which manifests as an accumulation of CD4(+) and CD8(+) T…”
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IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca 2+ through the noncanonical STAT3 pathway by Valença-Pereira, Felipe, Fang, Qian, Marié, Isabelle J, Giddings, Emily L, Fortner, Karen A, Yang, Rui, Villarino, Alejandro V, Huang, Yina H, Frank, David A, Wen, Haitao, Levy, David E, Rincon, Mercedes

“…Interleukin 6 (IL-6) is known to regulate the CD4 T cell function by inducing gene expression of a number of cytokines through activation of Stat3…”
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Cellular FLIP Long Form-Transgenic Mice Manifest a Th2 Cytokine Bias and Enhanced Allergic Airway Inflammation by Wu, Wenfang, Rinaldi, Lisa, Fortner, Karen A, Russell, Jennifer Q, Tschopp, Jurg, Irvin, Charles, Budd, Ralph C

“…Cellular FLIP long form (c-FLIP(L)) is a caspase-defective homologue of caspase-8 that blocks apoptosis by death receptors. The expression of c-FLIP(L) in T…”
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The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns by Fortner, Karen A, Bond, Jeffrey P, Austin, James W, Boss, Jeremy M, Budd, Ralph C

“…Abstract T lymphocyte homeostatic proliferation, driven by the engagement of T cell antigen receptor with self-peptide/major histocompatibility complexes, and…”
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The c-FLIPL Cleavage Product p43FLIP Promotes Activation of Extracellular Signal-regulated Kinase (ERK), Nuclear Factor κB (NF-κB), and Caspase-8 and T Cell Survival by Koenig, Andreas, Buskiewicz, Iwona A., Fortner, Karen A., Russell, Jennifer Q., Asaoka, Tomoko, He, You-Wen, Hakem, Razqallah, Eriksson, John E., Budd, Ralph C.

“…Caspase-8 is now appreciated to govern both apoptosis following death receptor ligation and cell survival and growth via inhibition of the Ripoptosome. Cells…”
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Glycolysis promotes caspase-3 activation in lipid rafts in T cells by Secinaro, Michael A., Fortner, Karen A., Dienz, Oliver, Logan, Angela, Murphy, Michael P., Anathy, Vikas, Boyson, Jonathan E., Budd, Ralph C.

“…Resting T cells undergo a rapid metabolic shift to glycolysis upon activation in the presence of interleukin (IL)-2, in contrast to oxidative mitochondrial…”
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Evidence that CD8 T-cell homeostasis and function remain intact during murine pregnancy by Norton, Michelle T, Fortner, Karen A, Oppenheimer, Karen H, Bonney, Elizabeth A

“…Evolving models of immune tolerance have challenged the view that the response of the maternal immune system to environmental or fetal antigens must be…”
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