Search Results - "Fortin, Samantha M"

The role of glia in the physiology and pharmacology of glucagon‐like peptide‐1: implications for obesity, diabetes, neurodegeneration and glaucoma by Cui, Qi N., Stein, Lauren M., Fortin, Samantha M., Hayes, Matthew R.

“…The medical applications of glucagon‐like peptide‐1 receptor (GLP‐1R) agonists is evergrowing in scope, highlighting the urgent need for a comprehensive…”
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Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling by Kanoski, Scott E, Fortin, Samantha M, Ricks, Katie M, Grill, Harvey J

“…Background The stomach-derived hormone ghrelin drives higher-order feeding processes related to food reward and food seeking via central nervous system…”
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GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models by Borner, Tito, Geisler, Caroline E, Fortin, Samantha M, Cosgrove, Richard, Alsina-Fernandez, Jorge, Dogra, Mridula, Doebley, Sarah, Sanchez-Navarro, Marcos J, Leon, Rosa M, Gaisinsky, Jane, White, Arianna, Bamezai, Ankur, Ghidewon, Misgana Y, Grill, Harvey J, Crist, Richard C, Reiner, Benjamin C, Ai, Minrong, Samms, Ricardo J, De Jonghe, Bart C, Hayes, Matthew R

“…Glucagon-like peptide 1 receptor (GLP-1R) agonists decrease body weight and improve glycemic control in obesity and diabetes. Patient compliance and maximal…”
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Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4 by Kanoski, Scott E, Fortin, Samantha M, Arnold, Myrtha, Grill, Harvey J, Hayes, Matthew R

“…The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonists, exendin-4 and liraglutide, suppress food intake and body weight. The mediating site(s) of…”
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The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide by Kanoski, Scott E., Rupprecht, Laura E., Fortin, Samantha M., De Jonghe, Bart C., Hayes, Matthew R.

“…The FDA-approved glucagon-like-peptide-1 receptor (GLP-1R) agonists exendin-4 and liraglutide reduce food intake and body weight. Nausea is the most common…”
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Physiological state gates acquisition and expression of mesolimbic reward prediction signals by Cone, Jackson J., Fortin, Samantha M., McHenry, Jenna A., Stuber, Garret D., McCutcheon, James E., Roitman, Mitchell F.

“…Phasic dopamine signaling participates in associative learning by reinforcing associations between outcomes (unconditioned stimulus; US) and their predictors…”
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Hippocampal Leptin Signaling Reduces Food Intake and Modulates Food-Related Memory Processing by KANOSKI, Scott E, HAYES, Matthew R, GREENWALD, Holly S, FORTIN, Samantha M, GIANESSI, Carol A, GILBERT, Jennifer R, GRILL, Harvey J

“…The increase in obesity prevalence highlights the need for a more comprehensive understanding of the neural systems controlling food intake; one that extends…”
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The Mesencephalic Trigeminal Nucleus Controls Food Intake and Body Weight via Hindbrain POMC Projections by Fortin, Samantha M., Chen, Jack, Grill, Harvey J., Hayes, Matthew R.

“…The mesencephalic trigeminal nucleus (Mes5) processes oral sensory–motor information, but its role in the control of energy balance remains unexplored. Here,…”
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Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis by Borner, Tito, Workinger, Jayme L., Tinsley, Ian C., Fortin, Samantha M., Stein, Lauren M., Chepurny, Oleg G., Holz, George G., Wierzba, Aleksandra J., Gryko, Dorota, Nexø, Ebba, Shaulson, Evan D., Bamezai, Ankur, Da Silva, Valentina A. Rodriguez, De Jonghe, Bart C., Hayes, Matthew R., Doyle, Robert P.

“…Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired…”
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Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology by Woodie, Lauren N, Melink, Lily C, Alberto, Ahren J, Burrows, Michelle, Fortin, Samantha M, Chan, Calvin C, Hayes, Matthew R, Lazar, Mitchell A

“…The dorsal vagal complex (DVC) of the hindbrain is a major point of integration for central and peripheral signals that regulate a wide variety of metabolic…”
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Central GLP-1 receptor activation modulates cocaine-evoked phasic dopamine signaling in the nucleus accumbens core by Fortin, Samantha M, Roitman, Mitchell F

“…Abstract Drugs of abuse increase the frequency and magnitude of brief (1–3 s), high concentration (phasic) dopamine release events in terminal regions. These…”
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Challenges to Body Fluid Homeostasis Differentially Recruit Phasic Dopamine Signaling in a Taste-Selective Manner by Fortin, Samantha M, Roitman, Mitchell F

“…The internal environment of an organism must remain stable to ensure optimal performance and ultimately survival. The generation of motivated behaviors is an…”
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GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats by Fortin, Samantha M, Lipsky, Rachele K, Lhamo, Rinzin, Chen, Jack, Kim, Eun, Borner, Tito, Schmidt, Heath D, Hayes, Matthew R

“…The glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide is approved for the treatment of obesity; however, there is still much to be learned…”
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The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior–posterior axis specification in one-cell C. elegans embryos by Fortin, Samantha M., Marshall, Sara L., Jaeger, Eva C., Greene, Pauline E., Brady, Lauren K., Isaac, R. Elwyn, Schrandt, Jennifer C., Brooks, Darren R., Lyczak, Rebecca

“…In the one-cell Caenorhabditis elegans embryo, the anterior–posterior (A–P) axis is established when the sperm donated centrosome contacts the posterior…”
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Hindbrain melanocortin 3/4 receptors modulate the food intake and body weight suppressive effects of the GLP-1 receptor agonist, liraglutide by Fortin, Samantha M., Chen, Jack, Hayes, Matthew R.

“…•The full anorectic potential of liraglutide requires DVC MC3/4Rs.•Agonism of DVC MC3/4Rs potentiates the food intake and body weight suppressive effects of…”
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Physiological state tunes mesolimbic signaling: Lessons from sodium appetite and inspiration from Randall R. Sakai by Fortin, Samantha M, Roitman, Mitchell F

“…Abstract Sodium deficit poses a life-threatening challenge to body fluid homeostasis and generates a sodium appetite - the behavioral drive to ingest sodium…”
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The Aversive Agent Lithium Chloride Suppresses Phasic Dopamine Release Through Central GLP-1 Receptors by Fortin, Samantha M, Chartoff, Elena H, Roitman, Mitchell F

“…Unconditioned rewarding stimuli evoke phasic increases in dopamine concentration in the nucleus accumbens (NAc) while discrete aversive stimuli elicit pauses…”
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The long-acting amylin/calcitonin receptor agonist ZP5461 suppresses food intake and body weight in male rats by Stein, Lauren M, McGrath, Lauren E, Lhamo, Rinzin, Koch-Laskowski, Kieran, Fortin, Samantha M, Skarbaliene, Jolanta, Baader-Pagler, Tamara, Just, Rasmus, Hayes, Matthew R, Mietlicki-Baase, Elizabeth G

“…The peptide hormone amylin reduces food intake and body weight and is an attractive candidate target for novel pharmacotherapies to treat obesity. However, the…”
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Leptin Signaling in the Medial Nucleus Tractus Solitarius Reduces Food Seeking and Willingness to Work for Food by KANOSKI, Scott E, ALHADEFF, Amber L, FORTIN, Samantha M, GILBERT, Jennifer R, GRILL, Harvey J

“…The adipose-derived hormone leptin signals in the medial nucleus tractus solitarius (mNTS) to suppress food intake, in part, by amplifying within-meal…”
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The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1 by Hayes, Matthew R, Kanoski, Scott E, De Jonghe, Bart C, Leichner, Theresa M, Alhadeff, Amber L, Fortin, Samantha M, Arnold, Myrtha, Langhans, Wolfgang, Grill, Harvey J

“…The incretin and food intake suppressive effects of intraperitoneally administered glucagon-like peptide-1 (GLP-1) involve activation of GLP-1 receptors…”
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