Search Results - "Fortin, Réjean"
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Feeding Ecology of Juvenile Lake Sturgeon in the St. Lawrence River System
Published in Transactions of the American Fisheries Society (1900) (01-07-2006)“…We examined the diet of juvenile lake sturgeon Acipenser fulvescens at five sites in the St. Lawrence River, including two sites in major tributaries (Des…”
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Identification of a new biaryl scaffold generating potent renin inhibitors
Published in Bioorganic & medicinal chemistry letters (01-10-2010)“…The discovery and SAR of a series of potent renin inhibitors possessing a novel biaryl scaffold are described herein. Molecular modeling revealed that the…”
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Fish community structure in relation to environmental variation in floodplain lakes of the Araguaia River, Amazon Basin
Published in Environmental biology of fishes (01-04-1998)“…We examined the relationship between structure of fish communities and 11 environmental variables in floodplain lakes from the Middle Araguaia River, Brazil…”
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Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability
Published in Journal of medicinal chemistry (27-09-1996)“…Naphthalenic lignan lactone 3a (L-702,539), a potent and selective 5-lipoxygenase (5-LO) inhibitor, is extensively metabolized at two different sites: the…”
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Reproduction of the Northern Leopard Frog (Rana pipiens) in Floodplain Habitat in the Richelieu River, P. Quebec, Canada
Published in Journal of herpetology (01-12-1994)“…We studied the reproductive ecology and characterized the spawning habitat of northern leopard frogs (Rana pipiens) during the spring of 1986 on a floodplain…”
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Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones
Published in Bioorganic & medicinal chemistry letters (15-03-2007)“…Caspase-3 is a cysteinyl protease that mediates apoptotic cell death. Its inhibition may have an important impact on the treatment of several degenerative…”
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2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: Selective and orally active cyclooxygenase-2 inhibitors
Published in Bioorganic & medicinal chemistry letters (06-10-1998)“…A series of novel 2-pyridinyl-3-(4-methylsulfonyl)phenylpyridines has been synthesized and evaluated with respect to their ability to inhibit the isozymes of…”
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Structure–activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP 4 receptor
Published in Bioorganic & medicinal chemistry letters (2008)“…A new series of EP 4 antagonists based on a quinoline acylsulfonamide scaffold have been identified as part of our on-going efforts to develop treatments for…”
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In vivo testing of the functional integrity of the corticosterone-producing axis in mudpuppy (amphibia) exposed to chlorinated hydrocarbons in the wild
Published in Environmental toxicology and chemistry (01-08-1997)“…The functional integrity of the hypothalamo–pituitary–interrenal (HPI) axis was tested in an aquatic salamander, the mudpuppy (Necturus maculosus), exposed in…”
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Identification and isolation of a membrane protein necessary for leukotriene production
Published in Nature (London) (18-01-1990)“…Several inflammatory diseases, including asthma, arthritis and psoriasis are associated with the production of leukotrienes by neutrophils, mast cells and…”
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2-Heterosubstituted-3-(4-methylsulfonyl)phenyl-5-trifluoromethyl pyridines as selective and orally active cyclooxygenase-2 inhibitors
Published in Bioorganic & medicinal chemistry letters (21-06-1999)“…A series of novel 2-alkoxy, 2-thioalkoxy and 2-amino-3-(4-methylsulfonyl)phenylpyridines has been synthesized and shown to be highly potent and selective…”
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Symmetrical alkoxysilyl ethers. A new class of alcohol-protecting groups. Preparation of tert-butoxydiphenylsilyl ethers
Published in Journal of organic chemistry (01-05-1988)Get full text
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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor
Published in Bioorganic & medicinal chemistry letters (15-03-2008)“…A new series of EP(4) antagonists based on a quinoline acylsulfonamide scaffold have been identified as part of our on-going efforts to develop treatments for…”
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5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors
Published in Molecular pharmacology (01-07-1991)“…An indole class of leukotriene synthesis inhibitors, exemplified by MK-886, which does not directly inhibit 5-lipoxygenase, has been shown to bind to an 18-kDa…”
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Direct synthesis of thio ethers from thiols and alcohols
Published in Journal of organic chemistry (01-04-1983)Get full text
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Novel 1,2-diarylcyclobutenes: Selective and orally active cox-2 inhibitors
Published in Bioorganic & medicinal chemistry letters (19-11-1996)“…A series of novel 2,3-diaryl-2-cyclobuten-1-ones have been synthesized and have been evaluated with respect to their ability to inhibit the isozymes of…”
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