Search Results - "Forsythe, Steven"

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening by Skardal, Aleksander, Devarasetty, Mahesh, Forsythe, Steven, Atala, Anthony, Soker, Shay

“…ABSTRACT Current animal and 2‐D cell culture models employed in metastasis research and drug discovery remain poor mimics of human cancer physiology. Here we…”
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Twenty Years Of Antiretroviral Therapy For People Living With HIV: Global Costs, Health Achievements, Economic Benefits by Forsythe, Steven S., McGreevey, William, Whiteside, Alan, Shah, Maunank, Cohen, Joshua, Hecht, Robert, Bollinger, Lori A., Kinghorn, Anthony

“…Since the introduction of azidothymidine in 1987, significant improvements in treatment for people living with HIV have yielded substantial improvements in…”
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Organoid Platform in Preclinical Investigation of Personalized Immunotherapy Efficacy in Appendiceal Cancer: Feasibility Study by Forsythe, Steven D, Erali, Richard A, Sasikumar, Shyama, Laney, Preston, Shelkey, Ethan, D'Agostino, Jr, Ralph, Miller, Lance D, Shen, Perry, Levine, Edward A, Soker, Shay, Votanopoulos, Konstantinos I

“…Immunotherapy efficacy data on appendiceal cancer from clinical trials does not exist, due to appendiceal cancer incidence of 0.97 per 100,000. The goal of…”
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Personalized Identification of Optimal HIPEC Perfusion Protocol in Patient-Derived Tumor Organoid Platform by Forsythe, Steven D., Sasikumar, Shyama, Moaven, Omeed, Sivakumar, Hemamylammal, Shen, Perry, Levine, Edward A., Soker, Shay, Skardal, Aleksander, Votanopoulos, Konstantinos I.

“…Background Chemotherapy dosing duration and perfusion temperature vary significantly in HIPEC protocols. This study investigates patient-derived tumor…”
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Long-Term Survival in Patients Treated with Cytoreduction and Heated Intraperitoneal Chemotherapy for Peritoneal Mesothelioma at a Single High-Volume Center by Valenzuela, Cristian D., Solsky, Ian B., Erali, Richard A., Forsythe, Steven D., Mangieri, Christopher W., Mainali, Bigyan B., Russell, Gregory, Perry, Kathleen C., Votanopoulos, Konstantinos I., Shen, Perry, Levine, Edward A.

“…Background Malignant peritoneal mesothelioma (MPM) is a rare diagnosis with a dismal prognosis if untreated. Cytoreductive surgery with hyperthermic…”
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Cell Viability Assays in Three-Dimensional Hydrogels: A Comparative Study of Accuracy by Dominijanni, Anthony J, Devarasetty, Mahesh, Forsythe, Steven D, Votanopoulos, Konstantinos I, Soker, Shay

“…Three-dimensional (3D) cell culture systems, such as tumor organoids and multicellular tumor spheroids, have been developed in part as a result of major…”
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TGFβ in Pancreas and Colorectal Cancer: Opportunities to Overcome Therapeutic Resistance by Johansen, Allan M, Forsythe, Steven D, McGrath, Callum T, Barker, Grayson, Jimenez, Hugo, Paluri, Ravi K, Pasche, Boris C

“…TGFβ is a pleiotropic signaling pathway that plays a pivotal role in regulating a multitude of cellular functions. TGFβ has a dual role in cell regulation…”
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Application of immune enhanced organoids in modeling personalized Merkel cell carcinoma research by Forsythe, Steven D., Erali, Richard A., Laney, Preston, Sivakumar, Hemamylammal, Li, Wencheng, Skardal, Aleksander, Soker, Shay, Votanopoulos, Konstantinos I.

“…Merkel cell carcinoma (MCC) is a rare neuroendocrine cutaneous cancer, with incidence of less than 1/100,000, low survival rates and variable response to…”
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Voluntary medical male circumcision: modeling the impact and cost of expanding male circumcision for HIV prevention in eastern and southern Africa by Njeuhmeli, Emmanuel, Forsythe, Steven, Reed, Jason, Opuni, Marjorie, Bollinger, Lori, Heard, Nathan, Castor, Delivette, Stover, John, Farley, Timothy, Menon, Veena, Hankins, Catherine

“…There is strong evidence showing that voluntary medical male circumcision (VMMC) reduces HIV incidence in men. To inform the VMMC policies and goals of 13…”
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ASO Author Reflections: Sarcoma Organoids: Neutralizing the Word “Rare” in Rare Cancers by Forsythe, Steven D., Sivakumar, Hemamylammal, Erali, Richard A., Skardal, Aleksander, Votanopoulos, Konstantinos I.

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ASO Author Reflections: Patient-Derived Tumor Organoids—A Platform for a Precision Approach for Peritoneal Malignancies by Forsythe, Steven D., Moaven, Omeed, Votanopoulos, Konstantinos I.

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Cisplatin exhibits superiority over MMC as a perfusion agent in a peritoneal mesothelioma patient specific organoid HIPEC platform by Forsythe, Steven D., Erali, Richard A., Edenhoffer, Nicholas, Meeker, William, Wajih, Nadeem, Schaaf, Cecilia R., Laney, Preston, Vanezuela, Cristian D., Li, Wencheng, Levine, Edward A., Soker, Shay, Votanopoulos, Konstantinos I.

“…Peritoneal mesothelioma (PM) is a rare malignancy with poor prognosis, representing about 10–15% of all mesothelioma cases. Herein we apply PM patient-derived…”
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Voluntary medical male circumcision: an introduction to the cost, impact, and challenges of accelerated scaling up by Hankins, Catherine, Forsythe, Steven, Njeuhmeli, Emmanuel

“…Scaling up voluntary medical male circumcision (VMMC) for HIV prevention is cost saving and creates fiscal space in the future that otherwise would have been…”
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Environmental Toxin Screening Using Human-Derived 3D Bioengineered Liver and Cardiac Organoids by Forsythe, Steven D, Devarasetty, Mahesh, Shupe, Thomas, Bishop, Colin, Atala, Anthony, Soker, Shay, Skardal, Aleksander

“…Environmental toxins, such as lead and other heavy metals, pesticides, and other compounds, represent a significant health concern within the USA and around…”
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Enhancing the Efficacy of HIPEC Through Bromelain: A Preclinical Investigation in Appendiceal Cancer by Wajih, Nadeem, Erali, Richard A., Forsythe, Steven D., Schaaf, Cecilia R., Shen, Perry, Levine, Edward A., Soker, Shay, Morris, David L., Votanopoulos, Konstantinos I.

“…Introduction Appendiceal cancer (AC) excessive mucin production is a barrier to heated intraperitoneal chemotherapy (HIPEC) drug delivery. Bromelain is a…”
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ASO Visual Abstract: Enhancing the Efficacy of HIPEC Through Bromelain: A Preclinical Investigation in Appendiceal Cancer by Wajih, Nadeem, Erali, Richard A., Forsythe, Steven D., Schaaf, Cecilia R., Shen, Perry, Levine, Edward A., Soker, Shay, Morris, David L., Votanopoulos, Konstantinos I.

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Immersion Bioprinting of Tumor Organoids in Multi-Well Plates for Increasing Chemotherapy Screening Throughput by Maloney, Erin, Clark, Casey, Sivakumar, Hemamylammal, Yoo, KyungMin, Aleman, Julio, Rajan, Shiny A P, Forsythe, Steven, Mazzocchi, Andrea, Laxton, Adrian W, Tatter, Stephen B, Strowd, Roy E, Votanopoulos, Konstantinos I, Skardal, Aleksander

“…The current drug development pipeline takes approximately fifteen years and $2.6 billion to get a new drug to market. Typically, drugs are tested on…”
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Unit cost repositories for health program planning and evaluation: a report on research in practice with lessons learned by Bollinger, Lori A, Corlis, Joseph, Ombam, Regina, Forsythe, Steven, Resch, Stephen C

“…Most low- and middle-income countries have limited access to cost data that meets the needs of health policy-makers and researchers in health intervention…”
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Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells by Drzeniek, Norman M, Mazzocchi, Andrea, Schlickeiser, Stephan, Forsythe, Steven D, Moll, Guido, Geißler, Sven, Reinke, Petra, Gossen, Manfred, Gorantla, Vijay S, Volk, Hans-Dieter, Soker, Shay

“…The therapeutic efficacy of clinically applied mesenchymal stromal cells (MSCs) is limited due to their injection into harsh environments, resulting in the…”
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Effects of the implementation of the HIV Treat All guidelines on key ART treatment outcomes in Namibia by Vu, Lung, Burnett-Zieman, Brady, Stoman, Lizl, Luu, Minh, Mdala, Johnface, Granger, Krista, Forsythe, Steven, Zegeye, Abeje, Geibel, Scott

“…This study aimed to help the Namibian government understand the impact of Treat All implementation (started on April 1, 2017) on key antiretroviral therapy…”
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