Search Results - "Forsythe, M S"

Sodium bicarbonate for the treatment of lactic acidosis by Forsythe, S M, Schmidt, G A

“…Lactic acidosis often challenges the intensivist and is associated with a strikingly high mortality. Treatment involves discerning and correcting its…”
Get more information

Mutagenesis analysis of human SM22: characterization of actin binding by Fu, Yiping, Liu, Hong Wei, Forsythe, Sean M, Kogut, Paul, McConville, John F, Halayko, Andrew J, Camoretti-Mercado, Blanca, Solway, Julian

“…Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637 SM22 is a 201-amino acid actin-binding…”
Get full text

Comparative In Vitro Efficacy of Different Platelet Glycoprotein IIb/IIIa Antagonists on Platelet-Mediated Clot Strength Induced by Tissue Factor With Use of Thromboelastography: Differentiation Among Glycoprotein IIb/IIIa Antagonists by Mousa, Shaker A, Khurana, Sandeep, Forsythe, Mark S

“…ABSTRACTIn the present study, the in vitro efficacy of different platelet glycoprotein IIb/IIIa (GPIIb/IIIa) antagonists on platelet-fibrin–mediated clot…”
Get full text

Antiplatelet and antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa receptor antagonist by MOUSA, S. A, BOZARTH, J. M, DE GRADO, W. F, THOOLEN, M. J, REILLY, T. M, FORSYTHE, M. S, JACKSON, S. M, LEAMY, A, DIEMER, M. M, KAPIL, R. P, KNABB, R. M, MAYO, M. C, PIERCE, S. K

“…Currently used antiplatelet drugs, including aspirin, ticlopidine, and others, are effective against certain but not all of the many endogenous platelet…”
Get full text

Expression and Cytogenetic Localization of the Human SM22 Gene (TAGLN) by Camoretti-Mercado, Blanca, Forsythe, Sean M., LeBeau, Michelle M., Espinosa, Rafael, Vieira, Joaquim E., Halayko, Andrew J., Willadsen, Stephanie, Kurtz, Bradley, Ober, Carole, Evans, Glen A., Thweatt, Ray, Shapiro, Stephanie, Niu, Qun, Qin, Yimin, Padrid, Philip A., Solway, Julian

“…SM22 is a 22-kDa protein identified variously as SM22, transgelin, WS3-10, or mouse p27. Though its precise function is unknown, it is abundant in smooth…”
Get full text

Transcriptional regulation of smooth muscle contractile apparatus expression by SOLWAY, J, FORSYTHE, S. M, HALAYKO, A. J, VIEIRA, J. E, HERSHENSON, M. B, CAMORETTI-MERCADO, B

“…The transcriptional regulatory mechanisms that control gene expression during differentiation and contractile protein accumulation are becoming well understood…”
Get full text

Ca++ utilization in the constriction of rat aorta to stimulation of protein kinase C by phorbol dibutyrate by Chiu, A T, Bozarth, J M, Forsythe, M S, Timmermans, P B

“…To determine the role of activated protein kinase C in vascular smooth muscle contraction, phorbol dibutyrate was used to stimulate this enzyme in order to…”
Get more information

Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes by Halayko, A J, Camoretti-Mercado, B, Forsythe, S M, Vieira, J E, Mitchell, R W, Wylam, M E, Hershenson, M B, Solway, J

“…We tested the hypothesis that prolonged serum deprivation would allow a subset of cultured airway myocytes to reacquire the abundant contractile protein…”
Get full text

Oral Antiplatelet Efficacy and Specificity of a Novel Nonpeptide Platelet GPIIb/IIIa Receptor Antagonist, DMP 802 by Mousa, Shaker A, Olson, Richard E, Bozarth, Jeffrey M, Lorelli, William, Forsythe, Mark S, Racanelli, Adrienne, Gibbs, Sandy, Schlingman, Karen, Bozarth, Tracy, Kapil, Ram, Wityak, John, Sielecki, Thais M, Wexler, Ruth R, Thoolen, Martin J, Slee, Andrew, Reilly, Thomas M, Anderson, Paul S, Friedman, Paul A

“…This study was undertaken to define the platelet glycoprotein αIIbβ3 integrin (GPII/IIIa) affinity, specificity, and oral antiplatelet efficacy of DMP 802, a…”
Get full text

Physiological Control of Smooth Muscle-specific Gene Expression through Regulated Nuclear Translocation of Serum Response Factor by Camoretti-Mercado, Blanca, Liu, Hong-W., Halayko, Andrew J., Forsythe, Sean M., Kyle, John W., Li, Bei, Fu, Yiping, McConville, John, Kogut, Paul, Vieira, Joaquim E., Patel, Nina M., Hershenson, Marc B., Fuchs, Elaine, Sinha, Satrajit, Miano, Joseph M., Parmacek, Michael S., Burkhardt, Janis K., Solway, Julian

“…Prolonged serum deprivation induces a structurally and functionally contractile phenotype in about 1/6 of cultured airway myocytes, which exhibit morphological…”
Get full text

Antiplatelet efficacy and specificity of DMP728, a novel platelet GPIIb/IIIa receptor antagonist by Mousa, S A, Bozarth, J M, Forsythe, M S, Lorelli, W, Thoolen, M J, Ramachandran, N, Jackson, S, De Grado, W, Reilly, T M

“…The present study was undertaken to define the platelet GPIIb/IIIa affinity and specificity of DMP728, the cyclic…”
Get more information

Disubstituted indazoles as potent antagonists of the integrin alpha(v)beta(3) by Batt, D G, Petraitis, J J, Houghton, G C, Modi, D P, Cain, G A, Corjay, M H, Mousa, S A, Bouchard, P J, Forsythe, M S, Harlow, P P, Barbera, F A, Spitz, S M, Wexler, R R, Jadhav, P K

“…A new series of indazole-containing alpha(v)beta(3) integrin antagonists is described. Starting with lead compound 18a, variations in a number of structural…”
Get full text

Effect of single oral dose of aspirin on human platelet functions and plasma plasminogen activator inhibitor-1 by Mousa, S A, Forsythe, M S, Bozarth, J M, Reilly, T M

“…Previous reports documented the inhibitory efficacy of different doses of aspirin on arachidonic acid (AA)-induced platelet aggregation, however, the…”
Get more information

Effect of thrombin inhibitors on platelet functions: comparative analysis of DuP 714 and hirudin by Reilly, T M, Knabb, R M, Hassell, S M, Bozarth, J M, Forsythe, M S, Mayo, M C, Racanelli, A L, Mousa, S A

“…Since thrombin plays an important role in platelet-mediated arterial thrombosis, we have examined the antiplatelet activity of a synthetic thrombin inhibitor,…”
Get more information

Thrombolytic and antithrombotic efficacy of the platelet GPIIb-IIIa antagonist DMP728 by Mousa, S A, Forsythe, M S, Diemer, M, Bozarth, J M, Reilly, T M

“…This study was undertaken to determine the antithrombotic and thrombolytic efficacy of DMP728 alone and in conjunction with thrombolytic agents. Coronary…”
Get more information

Recombinant plasminogen activator inhibitor-1 protects platelets against the inhibitory effects of plasmin by Reilly, T M, Forsythe, M S, Racanelli, A L, Spitz, S M, Walton, H L, Mousa, S A

“…Plasmin-induced degradation of platelet glycoprotein Ib (GPIb), the von Willebrand factor (vWF) receptor, has been implicated as a mechanism contributing to…”
Get more information

Differential antiplatelet efficacy for various GPIIb/IIIa antagonists: Role of plasma calcium levels by MOUSA, Shaker A, BOZARTH, Jeffrey M, FORSYTHE, Mark S, SLEE, Andrew

“…The present study was undertaken to determine the effects of free ionized calcium influenced by either the anticoagulant used (citrate vs. heparin) or directly…”
Get full text

Comparison of the effect of different platelet GPIIb/IIa antagonists on the dynamics of platelet/fibrin-mediated clot strength induced using thromboelastography by MOUSA, Shaker A, FORSYTHE, Mark S

“…The effect of various platelet glycoprotein IIb/IIIa (GPIIb/IIIa) antagonists on the dynamics of platelet-fibrin clot formation and strength induced by various…”
Get full text

Fas cross-linking induces apoptosis in human airway smooth muscle cells by Hamann, K J, Vieira, J E, Halayko, A J, Dorscheid, D, White, S R, Forsythe, S M, Camoretti-Mercado, B, Rabe, K F, Solway, J

“…Hypertrophy and hyperplasia lead to excess accumulation of smooth muscle in the airways of human asthmatic subjects. However, little is known about mechanisms…”
Get more information

Consumer patronage and risk perceptions in Internet shopping by Forsythe, Sandra M, Shi, Bo

“…Internet shopping has become the fastest-growing use of the Internet; most online consumers, however, use information gathered online to make purchases…”
Get full text