Search Results - "Forsyth, Trevor"
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Structure of Cellulose Microfibrils in Primary Cell Walls from Collenchyma
Published in Plant physiology (Bethesda) (01-01-2013)“…In the primary walls of growing plant cells, the glucose polymer cellulose is assembled into long microfibrils a few nanometers in diameter. The rigidity and…”
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2
Biomolecular Deuteration for Neutron Structural Biology and Dynamics
Published in Methods in enzymology (01-01-2016)“…Neutron scattering studies provide important information in structural biology that is not accessible using other approaches. The uniqueness of the technique,…”
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3
Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles
Published in ACS nano (27-04-2021)“…Emerging therapeutic treatments based on the production of proteins by delivering mRNA have become increasingly important in recent times. While lipid…”
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4
SARS-CoV-2 spike protein removes lipids from model membranes and interferes with the capacity of high density lipoprotein to exchange lipids
Published in Journal of colloid and interface science (15-11-2021)“…[Display omitted] Cholesterol has been shown to affect the extent of coronavirus binding and fusion to cellular membranes. The severity of Covid-19 infection…”
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5
Nanostructure of cellulose microfibrils in spruce wood
Published in Proceedings of the National Academy of Sciences - PNAS (22-11-2011)“…The structure of cellulose microfibrils in wood is not known in detail, despite the abundance of cellulose in woody biomass and its importance for biology,…”
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6
Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding
Published in Nature communications (11-01-2022)“…The opportunistic pathogen Pseudomonas aeruginosa , a major cause of nosocomial infections, uses carbohydrate-binding proteins (lectins) as part of its binding…”
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Untangling the threads of cellulose mercerization
Published in Nature communications (19-10-2022)“…Naturally occurring plant cellulose, our most abundant renewable resource, consists of fibers of long polymer chains that are tightly packed in parallel arrays…”
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8
A molecular mechanism for transthyretin amyloidogenesis
Published in Nature communications (25-02-2019)“…Human transthyretin (TTR) is implicated in several fatal forms of amyloidosis. Many mutations of TTR have been identified; most of these are pathogenic, but…”
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Light-emitting self-assembled peptide nucleic acids exhibit both stacking interactions and Watson–Crick base pairing
Published in Nature nanotechnology (01-04-2015)“…The two main branches of bionanotechnology involve the self-assembly of either peptides or DNA. Peptide scaffolds offer chemical versatility, architectural…”
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Conformational States of ABC Transporter MsbA in a Lipid Environment Investigated by Small-Angle Scattering Using Stealth Carrier Nanodiscs
Published in Structure (London) (07-08-2018)“…Structural studies of integral membrane proteins (IMPs) are challenging, as many of them are inactive or insoluble in the absence of a lipid environment. Here,…”
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The Rheological and Structural Properties of Fmoc-Peptide-Based Hydrogels: The Effect of Aromatic Molecular Architecture on Self-Assembly and Physical Characteristics
Published in Langmuir (31-01-2012)“…Biocompatible hydrogels are of high interest as a class of biomaterials for tissue engineering, regenerative medicine, and controlled drug delivery. These…”
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The impact of folding modes and deuteration on the atomic resolution structure of hen egg‐white lysozyme
Published in Acta crystallographica. Section D, Biological crystallography. (01-12-2021)“…The biological function of a protein is intimately related to its structure and dynamics, which in turn are determined by the way in which it has been folded…”
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Metal Ion Roles and the Movement of Hydrogen during Reaction Catalyzed by D-Xylose Isomerase: A Joint X-Ray and Neutron Diffraction Study
Published in Structure (London) (09-06-2010)“…Conversion of aldo to keto sugars by the metalloenzyme D-xylose isomerase (XI) is a multistep reaction that involves hydrogen transfer. We have determined the…”
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Localization of Cholesterol within Supported Lipid Bilayers Made of a Natural Extract of Tailor-Deuterated Phosphatidylcholine
Published in Langmuir (09-01-2018)“…Cholesterol is an essential component of mammalian membranes and is known to induce a series of physicochemical changes in the lipid bilayer. Such changes…”
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Nanostructural deformation of high-stiffness spruce wood under tension
Published in Scientific reports (11-01-2021)“…Conifer wood is an exceptionally stiff and strong material when its cellulose microfibrils are well aligned. However, it is not well understood how the polymer…”
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Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions
Published in Structure (London) (02-09-2021)“…Carbohydrate-binding proteins from pathogenic bacteria and fungi have been shown to be implicated in various pathological processes, where they interact with…”
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Diffraction evidence for the structure of cellulose microfibrils in bamboo, a model for grass and cereal celluloses
Published in BMC plant biology (23-06-2015)“…Cellulose from grasses and cereals makes up much of the potential raw material for biofuel production. It is not clear if cellulose microfibrils from grasses…”
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18
Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis
Published in Molecular systems biology (01-05-2021)“…The co‐catabolism of multiple host‐derived carbon substrates is required by Mycobacterium tuberculosis (Mtb) to successfully sustain a tuberculosis infection…”
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High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner
Published in Journal of colloid and interface science (01-09-2023)“…[Display omitted] There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of…”
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Adsorption of Denaturated Lysozyme at the Air–Water Interface: Structure and Morphology
Published in Langmuir (01-05-2018)“…The application of protein deuteration and high flux neutron reflectometry has allowed a comparison of the adsorption properties of lysozyme at the air–water…”
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