Search Results - "Forsyth, Nicholas"

Telomerase Regulation: A Role for Epigenetics by Dogan, Fatma, Forsyth, Nicholas R

“…Telomerase was first described by Greider and Blackburn in 1984, a discovery ultimately recognized by the Nobel Prize committee in 2009. The three decades…”
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Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin by Mycroft-West, Courtney J, Su, Dunhao, Pagani, Isabel, Rudd, Timothy R, Elli, Stefano, Gandhi, Neha S, Guimond, Scott E, Miller, Gavin J, Meneghetti, Maria C Z, Nader, Helena B, Li, Yong, Nunes, Quentin M, Procter, Patricia, Mancini, Nicasio, Clementi, Massimo, Bisio, Antonella, Forsyth, Nicholas R, Ferro, Vito, Turnbull, Jeremy E, Guerrini, Marco, Fernig, David G, Vicenzi, Elisa, Yates, Edwin A, Lima, Marcelo A, Skidmore, Mark A

“…The dependence of development and homeostasis in animals on the interaction of hundreds of extracellular regulatory proteins with the peri- and extracellular…”
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Hypoxia-Modified Cancer Cell Metabolism by Al Tameemi, Wafaa, Dale, Tina P, Al-Jumaily, Rakad M Kh, Forsyth, Nicholas R

“…While oxygen is critical to the continued existence of complex organisms, extreme levels of oxygen within a system, known as hypoxia (low levels of oxygen) and…”
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Stem cell-based therapy for human diseases by Hoang, Duc M., Pham, Phuong T., Bach, Trung Q., Ngo, Anh T. L., Nguyen, Quyen T., Phan, Trang T. K., Nguyen, Giang H., Le, Phuong T. T., Hoang, Van T., Forsyth, Nicholas R., Heke, Michael, Nguyen, Liem Thanh

“…Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based…”
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Lung Regeneration: Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches by Akram, Khondoker M, Patel, Neil, Spiteri, Monica A, Forsyth, Nicholas R

“…The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become…”
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Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors by Chen, Ruoli, Lai, U Hin, Zhu, Lingling, Singh, Ayesha, Ahmed, Muhammad, Forsyth, Nicholas R

“…Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the regulation of cell responses to varying oxygen levels. HIF…”
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Mesenchymal stem cells promote alveolar epithelial cell wound repair in vitro through distinct migratory and paracrine mechanisms by Akram, Khondoker M, Samad, Sohel, Spiteri, Monica A, Forsyth, Nicholas R

“…Mesenchymal stem cells (MSC) are in clinical trials for widespread indications including musculoskeletal, neurological, cardiac and haematological disorders…”
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In Vitro Innovation of Tendon Tissue Engineering Strategies by Citeroni, Maria Rita, Ciardulli, Maria Camilla, Russo, Valentina, Della Porta, Giovanna, Mauro, Annunziata, El Khatib, Mohammad, Di Mattia, Miriam, Galesso, Devis, Barbera, Carlo, Forsyth, Nicholas R, Maffulli, Nicola, Barboni, Barbara

“…Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon healing results in scar tissue formation and fibrosis with suboptimal…”
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TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity by Dogan, Fatma, Forsyth, Nicholas R

“…Telomere repeats protect linear chromosomes from degradation, and telomerase has a prominent role in their maintenance. Telomerase has telomere-independent…”
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Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination by Gomes, Nuno M. V., Ryder, Oliver A., Houck, Marlys L., Charter, Suellen J., Walker, William, Forsyth, Nicholas R., Austad, Steven N., Venditti, Chris, Pagel, Mark, Shay, Jerry W., Wright, Woodring E.

“…Summary Progressive telomere shortening from cell division (replicative aging) provides a barrier for human tumor progression. This program is not conserved in…”
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Chorionic and amniotic membrane-derived stem cells have distinct, and gestational diabetes mellitus independent, proliferative, differentiation, and immunomodulatory capacities by Chen, Liyun, Merkhan, Marwan M., Forsyth, Nicholas R., Wu, Pensee

“…Placental membrane-derived mesenchymal stem cells (MSCs), with the advantages of being non-invasive and having fewer ethical issues, are a promising source for…”
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Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis by Kay, Alasdair G, Treadwell, Kane, Roach, Paul, Morgan, Rebecca, Lodge, Rhys, Hyland, Mairead, Piccinini, Anna M, Forsyth, Nicholas R, Kehoe, Oksana

“…Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in…”
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Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells by Dogan, Fatma, Aljumaily, Rakad M Kh, Kitchen, Mark, Forsyth, Nicholas R

“…Pluripotent stem cells (PSC) possess unlimited proliferation, self-renewal, and a differentiation capacity spanning all germ layers. Appropriate culture…”
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Tenogenic Differentiation of Human Embryonic Stem Cells by Dale, Tina P, Mazher, Shazia, Webb, William R, Zhou, Jing, Maffulli, Nicola, Chen, Guo-Qiang, El Haj, Alicia J, Forsyth, Nicholas R

“…Tendon healing is complex to manage because of the limited regeneration capacity of tendon tissue; stem cell-based tissue engineering approaches may provide…”
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Three-dimensional hypoxic culture of human mesenchymal stem cells encapsulated in a photocurable, biodegradable polymer hydrogel: A potential injectable cellular product for nucleus pulposus regeneration by Kumar, Deepak, Gerges, Irini, Tamplenizza, Margherita, Lenardi, Cristina, Forsyth, Nicholas R., Liu, Yang

“…[Display omitted] Nucleus pulposus (NP) tissue damage can induce detrimental mechanical stresses and strains on the intervertebral disc, leading to disc…”
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Endotenon-Derived Type II Tendon Stem Cells Have Enhanced Proliferative and Tenogenic Potential by Clerici, Marta, Citro, Vera, Byrne, Amy L., Dale, Tina P., Boccaccini, Aldo R., Della Porta, Giovanna, Maffulli, Nicola, Forsyth, Nicholas R.

“…Tendon injuries caused by overuse or age-related deterioration are frequent. Incomplete knowledge of somatic tendon cell biology and their progenitors has…”
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Syndecan-3 regulates MSC adhesion, ERK and AKT signalling in vitro and its deletion enhances MSC efficacy in a model of inflammatory arthritis in vivo by Jones, Fiona K., Stefan, Andrei, Kay, Alasdair G., Hyland, Mairead, Morgan, Rebecca, Forsyth, Nicholas R., Pisconti, Addolorata, Kehoe, Oksana

“…Rheumatoid arthritis (RA) is a debilitating and painful inflammatory autoimmune disease characterised by the accumulation of leukocytes in the synovium,…”
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Tendon and Cytokine Marker Expression by Human Bone Marrow Mesenchymal Stem Cells in a Hyaluronate/Poly-Lactic-Co-Glycolic Acid (PLGA)/Fibrin Three-Dimensional (3D) Scaffold by Ciardulli, Maria C, Marino, Luigi, Lovecchio, Joseph, Giordano, Emanuele, Forsyth, Nicholas R, Selleri, Carmine, Maffulli, Nicola, Porta, Giovanna Della

“…We developed a (three-dimensional) 3D scaffold, we named HY-FIB, incorporating a force-transmission band of braided hyaluronate embedded in a cell localizing…”
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Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro by Dale, Tina P., Santer, Michael D., Haris, Mohammed, Zuo, Wei, Forsyth, Nicholas R.

“…Chronic obstructive pulmonary disease (COPD) patients experience hypoxemia and lung tissue hypoxia, causing vasoconstriction, and at its most severe Cor…”
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Chorionic and amniotic placental membrane‐derived stem cells, from gestational diabetic women, have distinct insulin secreting cell differentiation capacities by Chen, Liyun, Forsyth, Nicholas R., Wu, Pensee

“…Women with gestational diabetes mellitus (GDM), and their offspring, are at high risk of developing type 2 diabetes. Chorionic (CMSCs) and amniotic mesenchymal…”
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