Search Results - "Forssmann, U."

Phase 2, open-label, 1:1 randomized controlled trial exploring the efficacy of EMD 1201081 in combination with cetuximab in second-line cetuximab-naïve patients with recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) by Ruzsa, A., Sen, M., Evans, M., Lee, L. W., Hideghety, K., Rottey, S., Klimak, P., Holeckova, P., Fayette, J., Csoszi, T., Erfan, J., Forssmann, U., Goddemeier, T., Bexon, A., Nutting, C.

“…Summary Aim : to determine whether EMD 1201081, a TLR9 agonist, added to cetuximab had antitumor activity in second-line recurrent/metastatic squamous cell…”
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Chemokine receptor antagonists: a novel therapeutic approach in allergic diseases by Elsner, J., Escher, S. E., Forssmann, U.

“…The aim of this review is to give an overview of the role of chemokines, particularly ligands of the CC chemokine receptor CCR3, in allergic diseases and to…”
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Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity by García, José-Ramón Conejo, Krause, Alexander, Schulz, Sandra, Rodríguez-Jiménez, Francisco-Javier, Klüver, Enno, Adermann, Knut, Forssmann, Ulf, Frimpong-Boateng, Adjoa, Bals, Robert, Forssmann, Wolf-Georg

“…ABSTRACT β‐Defensins are antibiotic peptides involved in host defense at the epithelial surface. Three human β‐defensins (hBDs)‐‐hBD‐1, hBD‐2, and hBD‐3‐‐have…”
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n-Nonanoyl-CCL14 (NNY-CCL14), a novel inhibitor of allergic airway inflammation is a partial agonist of human CCR2 by Gupta, S, Erdmann, G, Schulz-Maronde, S, Escher, S.E, Richter, R, Forssmann, W.G, Elsner, J, Forssmann, U

“…Modulation of leukocyte recruitment through blocking of chemokine receptors has been proposed as an attractive therapeutic strategy. We have previously…”
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Conservative surgical treatment of diffuse peritonitis by Seiler, C.A., Brügger, L., Forssmann, U., Baer, H.U., Büchler, M.W.

“…Background: Peritonitis is, even today, a significant source of death and complications. The objective of this study was to determine the morbidity and…”
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Differential pattern of CCR1 internalization in human eosinophils: prolonged internalization by CCL5 in contrast to CCL3 by Elsner, J., Dulkys, Y., Gupta, S., Escher, S. E., Forssmann, W.‐G., Kapp, A., Forssmann, U.

“…Background:  Whereas recent studies underlie the fundamental importance of the CC chemokine receptor 3 (CCR3) for the recruitment of eosinophils in allergic…”
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The allergy‐associated chemokine receptors CCR3 and CCR5 can be inactivated by the modified chemokine NNY‐CCL11 by Manns, J., Rieder, S., Escher, S., Eilers, B., Forssmann, W.‐G., Elsner, J., Forssmann, U.

“…Background:  CC chemokine ligand 11 (CCL11) is the outstanding member of all described CC chemokine receptor 3 (CCR3) ligands and is shown to be selective for…”
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Inhibition Of Airway Inflammation And HIV Entry By NNY-CCL14 Treatment: Role Of CCR1 And CCR5 by Gupta, S, Fuchs, B, Schulz-Maronde, S, Heitland, A, Escher, S.E, Münch, J, Kirchhoff, F, Mack, M, Tillmann, H.C, Braun, A, Forssmann, W.G, Forssmann, U, Elsner, J

“…NNY-CCL14 treatment of OVA-sensitized BALB/c mice reduced influx of eosinophils (p = 0.021) and lymphocytes (p < 0.001) to bronchoalveolar lavage in…”
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Functional analysis of chemically synthesized derivatives of the human CC chemokine CCL15/HCC-2, a high affinity CCR1 ligand by Escher, S.E., Vakili, J., Forssmann, U., Frimpong-Boateng, A., Sticht, H., Detheux, M., Adermann, K.

“…:  The CCL15 is a human CC chemokine that activates the receptors, CCR1 and CCR3. Unlike other chemokines, it contains an unusually long N‐terminal domain of…”
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Dipeptidyl-Peptidase IV Modulates CCL11/Eotaxin-Induced Mobilization and Recruitment of Eosinophils by Forssmann, U.

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Rectus abdominis musculoperitoneal flap for closure of bladder defect by Schilling, M K, Forssmann, U, Kollmar, O, Büchler, M W

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Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction by García, J R, Jaumann, F, Schulz, S, Krause, A, Rodríguez-Jiménez, J, Forssmann, U, Adermann, K, Klüver, E, Vogelmeier, C, Becker, D, Hedrich, R, Forssmann, W G, Bals, R

“…Previous studies have shown the implication of beta-defensins in host defense of the human body. The human beta-defensins 1 and 2 (hBD-1, hBD-2) have been…”
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Simulations of cilengitide PK profiles in pediatric population by means of allometric scaling: Reliability and support to BSA-based dose adjustment strategy by Zuehlsdorf, M., Campioni, M., Forssmann, U., Munafo, A., Kovar, A.

“…Abstract only…”
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Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes by Forssmann, U, Uguccioni, M, Loetscher, P, Dahinden, C A, Langen, H, Thelen, M, Baggiolini, M

“…A novel human CC chemokine consisting of 78 amino acids and having a molecular mass of 8,778.3 daltons (VVIPSPCCMF FVSKRIPENR VVSYQLSSRS TCLKAGVIFT TKKGQQ SCGD…”
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Analysis of rare HLA-DRB1-DQB1 haplotypes in kidney donors and recipients by Scherer, S, Mytilineos, J, Forssmann, U, Dunckley, H, Trejaut, J, Chapman, J, Middleton, D, Opelz, G

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Mucin 1-specific active cancer immunotherapy with tecemotide (L-BLP25) in patients with multiple myeloma: An exploratory study by Rossmann, Eva, Österborg, Anders, Löfvenberg, Eva, Choudhury, Aniruddha, Forssmann, Ulf, von Heydebreck, Anja, Schröder, Andreas, Mellstedt, Håkan

“…Patients (n = 34) with previously untreated, slowly progressive asymptomatic stage I/II multiple myeloma or with stage II/III multiple myeloma in stable…”
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First-in-human trial focusing on the immunologic effects of the survivin-derived multiepitope vaccine EMD640744 by Gross, S., Lennerz, V., Gallerani, E., Sessa, C., Mach, N., Boehm, S., Hess, D., von Boehmer, L., Knuth, A., Ochsenbein, A., Gnad-Vogt, U., Zieschang, J., Forssmann, U., Woelfel, T., Kaempgen, E.

“…Abstract only…”
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Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties by Detheux, M, Ständker, L, Vakili, J, Münch, J, Forssmann, U, Adermann, K, Pöhlmann, S, Vassart, G, Kirchhoff, F, Parmentier, M, Forssmann, W G

“…Hemofiltrate CC chemokine (HCC)-1 is a recently described human chemokine that is constitutively expressed in numerous tissues and is present at high…”
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Quantum Proteolytic Activation of Chemokine CCL15 by Neutrophil Granulocytes Modulates Mononuclear Cell Adhesiveness by Richter, Rudolf, Bistrian, Roxana, Escher, Sylvia, Forssmann, Wolf-Georg, Vakili, Jalal, Henschler, Reinhard, Spodsberg, Nikolaj, Frimpong-Boateng, Adjoa, Forssmann, Ulf

“…Monocyte infiltration into inflammatory sites is generally preceded by neutrophils. We show here that neutrophils may support this process by activation of…”
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NNY-CCL14 Acts on Diverse CC Chemokine Receptors and Prevents Airway Hyperresponsiveness by Gupta, S., Forssmann, U., Schulz-Maronde, S., Fuchs, B., Braun, A., Forssmann, W.G., Elsner, J.

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