Search Results - "Forss, Sonja"

From peroxisomal disorders to common neurodegenerative diseases – the role of ether phospholipids in the nervous system by Dorninger, Fabian, Forss‐Petter, Sonja, Berger, Johannes

“…The emerging diverse roles of ether (phospho)lipids in nervous system development and function in health and disease are currently attracting growing interest…”
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Plasmalogens, platelet-activating factor and beyond – Ether lipids in signaling and neurodegeneration by Dorninger, Fabian, Forss-Petter, Sonja, Wimmer, Isabella, Berger, Johannes

“…Glycerol-based ether lipids including ether phospholipids form a specialized branch of lipids that in mammals require peroxisomes for their biosynthesis. They…”
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Reduced muscle strength in ether lipid‐deficient mice is accompanied by altered development and function of the neuromuscular junction by Dorninger, Fabian, Herbst, Ruth, Kravic, Bojana, Camurdanoglu, Bahar Z., Macinkovic, Igor, Zeitler, Gerhard, Forss‐Petter, Sonja, Strack, Siegfried, Khan, Muzamil Majid, Waterham, Hans R., Rudolf, Rüdiger, Hashemolhosseini, Said, Berger, Johannes

“…Inherited deficiency in ether lipids, a subgroup of phospholipids whose biosynthesis needs peroxisomes, causes the fatal human disorder rhizomelic…”
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Peroxisomes in brain development and function by Berger, Johannes, Dorninger, Fabian, Forss-Petter, Sonja, Kunze, Markus

“…Peroxisomes contain numerous enzymatic activities that are important for mammalian physiology. Patients lacking either all peroxisomal functions or a single…”
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Current and Future Pharmacological Treatment Strategies in X-Linked Adrenoleukodystrophy by Berger, Johannes, Pujol, Aurora, Aubourg, Patrick, Forss-Petter, Sonja

“…Mutations in the ABCD1 gene cause the clinical spectrum of the neurometabolic disorder X‐linked adrenoleukodystrophy/adrenomyeloneuropathy (X‐ALD/AMN)…”
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Targeting foam cell formation in inflammatory brain diseases by the histone modifier MS‐275 by Zierfuss, Bettina, Weinhofer, Isabelle, Buda, Agnieszka, Popitsch, Niko, Hess, Lena, Moos, Verena, Hametner, Simon, Kemp, Stephan, Köhler, Wolfgang, Forss‐Petter, Sonja, Seiser, Christian, Berger, Johannes

“…Objective To assess class I‐histone deacetylase (HDAC) inhibition on formation of lipid‐accumulating, disease‐promoting phagocytes upon myelin load in vitro,…”
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Neurofilament light chain as a potential biomarker for monitoring neurodegeneration in X-linked adrenoleukodystrophy by Weinhofer, Isabelle, Rommer, Paulus, Zierfuss, Bettina, Altmann, Patrick, Foiani, Martha, Heslegrave, Amanda, Zetterberg, Henrik, Gleiss, Andreas, Musolino, Patricia L., Gong, Yi, Forss-Petter, Sonja, Berger, Thomas, Eichler, Florian, Aubourg, Patrick, Köhler, Wolfgang, Berger, Johannes

“…X-linked adrenoleukodystrophy (X-ALD), the most frequent monogenetic disorder of brain white matter, is highly variable, ranging from slowly progressive…”
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Vorinostat in the acute neuroinflammatory form of X‐linked adrenoleukodystrophy by Zierfuss, Bettina, Weinhofer, Isabelle, Kühl, Jörn‐Sven, Köhler, Wolfgang, Bley, Annette, Zauner, Katharina, Binder, Johannes, Martinović, Ksenija, Seiser, Christian, Hertzberg, Christoph, Kemp, Stephan, Egger, Gerda, Leitner, Gerda, Bauer, Jan, Wiesinger, Christoph, Kunze, Markus, Forss‐Petter, Sonja, Berger, Johannes

“…Objective To identify a pharmacological compound targeting macrophages, the most affected immune cells in inflammatory X‐linked adrenoleukodystrophy (cerebral…”
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Impaired plasticity of macrophages in X-linked adrenoleukodystrophy by Weinhofer, Isabelle, Zierfuss, Bettina, Hametner, Simon, Wagner, Magdalena, Popitsch, Niko, Machacek, Christian, Bartolini, Barbara, Zlabinger, Gerhard, Ohradanova-Repic, Anna, Stockinger, Hannes, Köhler, Wolfgang, Höftberger, Romana, Regelsberger, Günther, Forss-Petter, Sonja, Lassmann, Hans, Berger, Johannes

“…Weinhofer et al. reveal impaired plasticity of macrophages, with intrinsic pro-inflammatory skewing and a decreased ability to establish proper…”
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Peroxisomal alterations in Alzheimer’s disease by Kou, Jianqiu, Kovacs, Gabor G., Höftberger, Romana, Kulik, Willem, Brodde, Alexander, Forss-Petter, Sonja, Hönigschnabl, Selma, Gleiss, Andreas, Brügger, Britta, Wanders, Ronald, Just, Wilhelm, Budka, Herbert, Jungwirth, Susanne, Fischer, Peter, Berger, Johannes

“…In Alzheimer’s disease (AD), lipid alterations are present early during disease progression. As some of these alterations point towards a peroxisomal…”
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Homeostasis of phospholipids — The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens by Dorninger, Fabian, Brodde, Alexander, Braverman, Nancy E., Moser, Ann B., Just, Wilhelm W., Forss-Petter, Sonja, Brügger, Britta, Berger, Johannes

“…Ethanolamine plasmalogens constitute a group of ether glycerophospholipids that, due to their unique biophysical and biochemical properties, are essential…”
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Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy by Raas, Quentin, van de Beek, Malu-Clair, Forss-Petter, Sonja, Dijkstra, Inge Me, Deschiffart, Abigail, Freshner, Briana C, Stevenson, Tamara J, Jaspers, Yorrick Rj, Nagtzaam, Liselotte, Wanders, Ronald Ja, van Weeghel, Michel, Engelen-Lee, Joo-Yeon, Engelen, Marc, Eichler, Florian, Berger, Johannes, Bonkowsky, Joshua L, Kemp, Stephan

“…X-linked adrenoleukodystrophy (ALD) is a progressive neurodegenerative disease caused by mutations in ABCD1, the peroxisomal very long-chain fatty acid (VLCFA)…”
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Saturated very long-chain fatty acids regulate macrophage plasticity and invasiveness by Zierfuss, Bettina, Buda, Agnieszka, Villoria-González, Andrea, Logist, Maxime, Fabjan, Jure, Parzer, Patricia, Battin, Claire, Vandersteene, Streggi, Dijkstra, Inge M E, Waidhofer-Söllner, Petra, Grabmeier-Pfistershammer, Katharina, Steinberger, Peter, Kemp, Stephan, Forss-Petter, Sonja, Berger, Johannes, Weinhofer, Isabelle

“…Saturated very long-chain fatty acids (VLCFA, ≥ C22), enriched in brain myelin and innate immune cells, accumulate in X-linked adrenoleukodystrophy (X-ALD) due…”
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Abcd1 deficiency accelerates cuprizone-induced oligodendrocyte loss and axonopathy in a demyelinating mouse model of X-linked adrenoleukodystrophy by Martinović, Ksenija, Bauer, Jan, Kunze, Markus, Berger, Johannes, Forss-Petter, Sonja

“…X-linked adrenoleukodystrophy (X-ALD), the most frequent, inherited peroxisomal disease, is caused by mutations in the ABCD1 gene encoding a peroxisomal lipid…”
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Overlapping and Distinct Features of Cardiac Pathology in Inherited Human and Murine Ether Lipid Deficiency by Dorninger, Fabian, Kiss, Attila, Rothauer, Peter, Stiglbauer-Tscholakoff, Alexander, Kummer, Stefan, Fallatah, Wedad, Perera-Gonzalez, Mireia, Hamza, Ouafa, König, Theresa, Bober, Michael B, Cavallé-Garrido, Tiscar, Braverman, Nancy E, Forss-Petter, Sonja, Pifl, Christian, Bauer, Jan, Bittner, Reginald E, Helbich, Thomas H, Podesser, Bruno K, Todt, Hannes, Berger, Johannes

“…Inherited deficiency in ether lipids, a subgroup of glycerophospholipids with unique biochemical and biophysical properties, evokes severe symptoms in humans…”
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ABCD1 Transporter Deficiency Results in Altered Cholesterol Homeostasis by Buda, Agnieszka, Forss-Petter, Sonja, Hua, Rong, Jaspers, Yorrick, Lassnig, Mark, Waidhofer-Söllner, Petra, Kemp, Stephan, Kim, Peter, Weinhofer, Isabelle, Berger, Johannes

“…X-linked adrenoleukodystrophy (X-ALD), the most common peroxisomal disorder, is caused by mutations in the peroxisomal transporter ABCD1, resulting in the…”
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Efficacy of HDAC Inhibitors in Driving Peroxisomal β-Oxidation and Immune Responses in Human Macrophages: Implications for Neuroinflammatory Disorders by Villoria-González, Andrea, Zierfuss, Bettina, Parzer, Patricia, Heuböck, Elisabeth, Zujovic, Violetta, Waidhofer-Söllner, Petra, Ponleitner, Markus, Rommer, Paulus, Göpfert, Jens, Forss-Petter, Sonja, Berger, Johannes, Weinhofer, Isabelle

“…Elevated levels of saturated very long-chain fatty acids (VLCFAs) in cell membranes and secreted lipoparticles have been associated with neurotoxicity and,…”
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Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1-deficient mice by Muneer, Zahid, Wiesinger, Christoph, Voigtländer, Till, Werner, Hauke B, Berger, Johannes, Forss-Petter, Sonja

“…The inherited peroxisomal disorder X-linked adrenoleukodystrophy (X-ALD), associated with neurodegeneration and inflammatory cerebral demyelination, is caused…”
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Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer by Pei, Zhengtong, Fraisl, Peter, Shi, Xiaohai, Gabrielson, Edward, Forss-Petter, Sonja, Berger, Johannes, Watkins, Paul A

“…Lung cancer is the leading cause of cancer deaths worldwide. In the United States, only one in six lung cancer patients survives five years after diagnosis…”
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Disturbed neurotransmitter homeostasis in ether lipid deficiency by Dorninger, Fabian, König, Theresa, Scholze, Petra, Berger, Michael L, Zeitler, Gerhard, Wiesinger, Christoph, Gundacker, Anna, Pollak, Daniela D, Huck, Sigismund, Just, Wilhelm W, Forss-Petter, Sonja, Pifl, Christian, Berger, Johannes

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