Search Results - "Forrester, L M"

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics by FORRESTER, L. M, HENDERSON, C. J, WOLF, C. R, GLANCEY, M. J, BACK, D. J, PARK, B. K, BALL, S. E, KITTERINGHAM, N. R, MCLAREN, A. W, MILES, J. S, SKETT, P

“…Cytochrome P450s play a central role in the metabolism and disposition of an extremely wide range of drugs and chemical carcinogens. Individual differences in…”
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Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues by Howie, A F, Forrester, L M, Glancey, M J, Schlager, J J, Powis, G, Beckett, G J, Hayes, J D, Wolf, C R

“…Glutathione S-transferases play a central role in drug detoxification and have been implicated in the sensitivity of tumour cells to anticancer drugs. In this…”
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Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver by FORRESTER, L. M, NEAL, G. E, JUDAH, D. J, GLANCEY, M. J, WOLF, C. R

“…Liver cancer is a major cause of premature death in many areas of Africa and Asia and its incidence is strongly correlated with exposure to aflatoxin B1…”
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Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity by Miles, J S, McLaren, A W, Forrester, L M, Glancey, M J, Lang, M A, Wolf, C R

“…1. We have constructed a full-length human liver cytochrome P450IIA cDNA from a partial-length clone by oligonucleotide-directed mutagenesis, and subcloned it…”
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An Induction Gene Trap Screen in Embryonic Stem Cells: Identification of Genes that Respond to Retinoic Acid in vitro by Forrester, Lesley M., Nagy, Andras, Sam, Mehran, Watt, Alistair, Stevenson, Lois, Bernstein, Alan, Joyner, Alexandra L., Wurst, Wolfgang

“…We have developed a novel induction gene trap approach that preselects in vitro for integrations into genes that lie downstream of receptor/ligand-mediated…”
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Bayesian inference of hospital-acquired infectious diseases and control measures given imperfect surveillance data by Forrester, M L, Pettitt, A N, Gibson, G J

“…This paper describes a stochastic epidemic model developed to infer transmission rates of asymptomatic communicable pathogens within a hospital ward. Inference…”
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Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy by Meehan, R R, Forrester, L M, Stevenson, K, Hastie, N D, Buchmann, A, Kunz, H W, Wolf, C R

“…Cytochrome P-450s are a superfamily of haem-containing proteins involved in the metabolism of foreign compounds, as well as a variety of endogenous molecules…”
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Long-Term Reconstitution of the Mouse Hematopoietic System by Embryonic Stem Cell-Derived Fetal Liver by FORRESTER, L. M, BERNSTEIN, A, ROSSANT, J, NAGY, A

“…Murine embryonic stem (ES) cells are permanent blastocyst-derived cell lines capable of contributing to a wide variety of tissues, including the germ line,…”
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Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines by LEWIS, A. D, FORRESTER, L. M, HAYES, J. D, WAREING, C. J, CARMICHAEL, J, HARRIS, A. L, MOOGHEN, M, WOLF, C. R

“…An increasing body of evidence indicates that glutathione S-transferases play a role in the intrinsic and acquired resistance of tumours to anticancer drugs…”
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Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue by Forrester, L M, Hayes, J D, Millis, R, Barnes, D, Harris, A L, Schlager, J J, Powis, G, Wolf, C R

“…The level of expression of glutathione S-transferases (GSTs) and cytochrome P450s in breast tissue are potentially important determinants in both the…”
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Enhanced expression of glutathione S-transferases in colorectal carcinoma compared to non-neoplastic mucosa by Moorghen, M, Cairns, J, Forrester, L M, Hayes, J D, Hall, A, Cattan, A R, Wolf, C R, Harris, A L

“…Ten paired samples of primary human colorectal carcinoma and adjacent non-neoplastic mucosa were analysed for total glutathione S-transferase (GST) activities…”
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Relative contribution of various forms of cytochrome P450 to the metabolism of benzo[a]pyrene by human liver microsomes by Hall, M, Forrester, L M, Parker, D K, Grover, P L, Wolf, C R

“…A variety of cytochromes P450 have been implicated in the hepatic metabolism of benzo[a]pyrene (BP), including forms that are constitutively expressed and…”
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Development of B lymphocytes in mice heterozygous for the X-linked immunodeficiency (xid) mutation: xid inhibits development of all splenic and lymph node B cells at a stage subsequent to their initial formation in bone marrow by FORRESTER, L. M, ANSELL, J. D, MICKLEM, H. S

“…CBA/N mice were crossed with CBA/Ca-Pgk-1a to produce female F1 hybrids that were heterozygous for both xid and the phosphoglycerate kinase 1 (PGK-1)…”
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Glutathione S-transferase isoenzymes and glutathione peroxidase activity in normal and tumour samples from human lung by Carmichael, J, Forrester, L M, Lewis, A D, Hayes, J D, Hayes, P C, Wolf, C R

“…An increasing body of evidence suggests that glutathione-dependent enzymes are an important factor in determining the sensitivity of tumours to cytotoxic…”
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The contribution of specific cytochromes P-450 in the metabolism of 7,12-dimethylbenz[a]anthracene in rat and human liver microsomal membranes by Morrison, V M, Burnett, A K, Forrester, L M, Wolf, C R, Craft, J A

“…The role of specific cytochrome P-450 isoenzymes in the regio-selective metabolism of 7,12-dimethylbenz[a]anthracene (DMBA) has been studied in microsomal…”
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Computer-assisted molecular modeling of benzodiazepine and thyromimetic inhibitors of the HepG2 iodothyronine membrane transporter by Kragie, L, Forrester, M L, Cody, V, McCourt, M

“…T3 cellular uptake is inhibited in the presence of benzodiazepines (BZs). The structure-activity relationship of BZ inhibition correlates strongly with halogen…”
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Metabolic basis for the protective effect of the antioxidant ethoxyquin on aflatoxin B1 hepatocarcinogenesis in the rat by MANDEL, H. G, MANSON, M. M, JUDAH, D. J, SIMPSON, J. L, GREEN, J. A, FORRESTER, L. M, WOLF, C. R, NEAL, G. E

“…The effect of dietary administration of 0.5% ethoxyquin (EQ) on the in vivo induction of enzymes and effect on aflatoxin B1 (AFB1)-DNA binding in liver and the…”
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Differences in the cytochrome P-450 isoenzymes involved in the 2-hydroxylation of oestradiol and 17 alpha-ethinyloestradiol. Relative activities of rat and human liver enzymes by Ball, S E, Forrester, L M, Wolf, C R, Back, D J

“…The metabolism of oestradiol and 17 alpha-ethinyloestradiol to their 2-hydroxy derivatives is an important determinant in their biological effects. In this…”
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Conformational analogs of antihypertensive agents related to guanethidine by Borne, R. F, Forrester, M. L, Waters, I. W

“…In an effort to clarify the conformational requirements, if any, of agents producing adrenergic neuronal blockade through mechanisms similar to guanethidine,…”
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Endogenous xenobiotic enzyme levels in mammalian cells by McGregor, D B, Edwards, I, Wolf, C R, Forrester, L M, Caspary, W J

“…The response of mammalian cell lines to chemicals depends, in part, on the exogenous activation system used for the induction of a biological response. This…”
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