Search Results - "Forrest, M. Laird"

Toxicity of nanomaterials by Sharifi, Shahriar, Behzadi, Shahed, Laurent, Sophie, Forrest, M Laird, Stroeve, Pieter, Mahmoudi, Morteza

“…Nanoscience has matured significantly during the last decade as it has transitioned from bench top science to applied technology. Presently, nanomaterials are…”
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Nanoparticles for biomedical imaging by Nune, Satish K, Gunda, Padmaja, Thallapally, Praveen K, Lin, Ying-Ying, Forrest, M Laird, Berkland, Cory J

“…Synthetic nanoparticles are emerging as versatile tools in biomedical applications, particularly in the area of biomedical imaging. Nanoparticles 1 - 100 nm in…”
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A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice by Varkhede, Ninad, Patel, Nita, Chang, William, Ruterbories, Kenneth, Laird Forrest, M.

“…Purpose To investigate influence of inflammation on metabolism and pharmacokinetics (PK) of midazolam (MDZ) and construct a semi-physiologically based…”
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Effects of nanomaterial physicochemical properties on in vivo toxicity by Aillon, Kristin L., Xie, Yumei, El-Gendy, Nashwa, Berkland, Cory J., Forrest, M. Laird

“…It is well recognized that physical and chemical properties of materials can alter dramatically at nanoscopic scale, and the growing use of nanotechnologies…”
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Human intratumoral therapy: Linking drug properties and tumor transport of drugs in clinical trials by Huang, Aric, Pressnall, Melissa M., Lu, Ruolin, Huayamares, Sebastian G., Griffin, J. Daniel, Groer, Chad, DeKosky, Brandon J., Forrest, M. Laird, Berkland, Cory J.

“…Cancer therapies aim to kill tumor cells directly or engage the immune system to fight malignancy. Checkpoint inhibitors, oncolytic viruses, cell-based…”
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Physical Non-Viral Gene Delivery Methods for Tissue Engineering by Mellott, Adam J., Forrest, M. Laird, Detamore, Michael S.

“…The integration of gene therapy into tissue engineering to control differentiation and direct tissue formation is not a new concept; however, successful…”
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Glatiramer acetate enhances tumor retention and innate activation of immunostimulants by Pressnall, Melissa M., Huang, Aric, Groer, Chad E., Huayamares, Sebastian G., Laird Forrest, M., Berkland, Cory J.

“…[Display omitted] Cancer immunotherapy aims to stimulate immune cells to recognize and attack tumor tissue. The immunostimulatory polyanions polyI:C and CpG…”
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Localized doxorubicin chemotherapy with a biopolymeric nanocarrier improves survival and reduces toxicity in xenografts of human breast cancer by Cai, Shuang, Thati, Sharadvi, Bagby, Taryn R., Diab, Hassam-Mustafa, Davies, Neal M., Cohen, Mark S., Forrest, M. Laird

“…Patients with metastatic breast cancer have a five-year survival rate of 27% compared to 98% for localized cancer, and the presence of even a few cancer cells…”
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Correction to: A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice by Varkhede, Ninad, Patel, Nita, Chang, William, Ruterbories, Kenneth, Forrest, M. Laird

“…One of the authors has his name incorrectly indexed in PubMed and SpringerLink as “Laird Forrest M” (last name “Laird Forrest”). His name should index as…”
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Understanding the hysteresis loop conundrum in pharmacokinetic/pharmacodynamic relationships by Louizos, Christopher, Yáñez, Jaime A, Forrest, M Laird, Davies, Neal M

“…Hysteresis loops are phenomena that sometimes are encountered in the analysis of pharmacokinetic and pharmacodynamic relationships spanning from pre-clinical…”
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Intralymphatic Chemotherapy Using a Hyaluronan–Cisplatin Conjugate by Cai, Shuang, M.S, Xie, Yumei, Ph.D, Bagby, Taryn R., B.S, Cohen, Mark S., M.D, Forrest, M. Laird, Ph.D

“…Background Breast cancers typically spread to regional lymph nodes once they disseminate from the primary tumor, thus adequate evaluation and treatment of the…”
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Intratracheal Administration of Hyaluronan-Cisplatin Conjugate Nanoparticles Significantly Attenuates Lung Cancer Growth in Mice by Ishiguro, Susumu, Cai, Shuang, Uppalapati, Deepthi, Turner, Katie, Zhang, Ti, Forrest, Wai Chee, Forrest, M. Laird, Tamura, Masaaki

“…Purpose To determine aerosol administration capability and therapeutic efficacy of the new formulation of hyaluronan cisplatin conjugates, HylaPlat™ (HA-Pt),…”
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Single-step grafting of aminooxy-peptides to hyaluronan: A simple approach to multifunctional therapeutics for experimental autoimmune encephalomyelitis by Sestak, Joshua, Mullins, Meagan, Northrup, Laura, Thati, Sharadvi, Laird Forrest, M., Siahaan, Teruna J., Berkland, Cory

“…The immune response to antigens is directed in part by the presence or absence of costimulatory signals. The ability to coincidently present both antigen and,…”
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Pulmonary delivery of cisplatin–hyaluronan conjugates via endotracheal instillation for the treatment of lung cancer by Xie, Yumei, Aillon, Kristin L., Cai, Shuang, Christian, Jason M., Davies, Neal M., Berkland, Cory J., Forrest, M. Laird

“…Cisplatin (CDDP) intravenous treatments suffer several dose-limiting toxicity issues. Hyaluronan (HA), a naturally occurring biopolymer in the interstitium, is…”
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Advances in lymphatic imaging and drug delivery by Nune, Satish K., Gunda, Padmaja, Majeti, Bharat K., Thallapally, Praveen K., Forrest, M. Laird

“…Cancer remains the second leading cause of death after heart disease in the US. While metastasized cancers such as breast, prostate, and colon are incurable,…”
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Drug delivery to the lymphatic system: importance in future cancer diagnosis and therapies by Xie, Yumei, Bagby, Taryn R, Cohen, M S, Forrest, M Laird

“…Cancer is the second leading cause of death in the US. Currently, protocols for cancer treatment include surgery to remove diseased and suspect tissues,…”
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Constructing a Biomaterial to Simulate Extracellular Drug Transport in Solid Tumors by Huayamares, Sebastian G., Song, Jimmy Y., Huang, Aric, Crowl, Samuel R., Groer, Chad E., Forrest, M. Laird, Berkland, Cory J.

“…Designing an in vitro model of the tumor extracellular microenvironment to screen intratumoral drugs is an active challenge. As recent clinical successes of…”
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Multi-arm polymeric nanocarrier as a nitric oxide delivery platform for chemotherapy of head and neck squamous cell carcinoma by Duan, Shaofeng, Cai, Shuang, Yang, Qiuhong, Forrest, M. Laird

“…Abstract Nitric oxide is a cell signaling molecule that can be a potent inducer of cell death in cancers at elevated concentrations. However, NO is also toxic…”
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Targeted nanodiamonds as phenotype-specific photoacoustic contrast agents for breast cancer by Zhang, Ti, Cui, Huizhong, Fang, Chia-Yi, Cheng, Kun, Yang, Xinmai, Chang, Huan-Cheng, Forrest, M Laird

“…The aim is to develop irradiated nanodiamonds (INDs) as a molecularly targeted contrast agent for high-resolution and phenotype-specific detection of breast…”
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Flip-flop pharmacokinetics--delivering a reversal of disposition: challenges and opportunities during drug development by Yáñez, Jaime A, Remsberg, Connie M, Sayre, Casey L, Forrest, M Laird, Davies, Neal M

“…Flip-flop pharmacokinetics is a phenomenon often encountered with extravascularly administered drugs. Occurrence of flip-flop spans preclinical to human…”
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