Search Results - "Forrest, C M"

Tryptophan metabolism and oxidative stress in patients with Huntington's disease by Stoy, N., Mackay, G. M., Forrest, C. M., Christofides, J., Egerton, M., Stone, T. W., Darlington, L. G.

“…Abnormalities in the kynurenine pathway may play a role in Huntington's disease (HD). In this study, tryptophan depletion and loading were used to investigate…”
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Involvement of the proteasome and caspase activation in hippocampal long-term depression induced by the serine protease subtilisin by Forrest, C.M, Darlington, L.G, Stone, T.W

“…Highlights ► The serine protease subtilisin induced hippocampal LTD with a non-classical modification of caspase-3 and caspase-9. ► Late subtilisin LTD is…”
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Tryptophan metabolism and oxidative stress in patients with chronic brain injury by Mackay, G. M., Forrest, C. M., Stoy, N., Christofides, J., Egerton, M., Stone, T. W., Darlington, L. G.

“…The kynurenine pathway generates the excitotoxic N‐methyl‐d‐aspartate receptor agonist, quinolinic acid and the glutamate antagonist, kynurenic acid, as well…”
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Blood 5‐hydroxytryptamine, 5‐hydroxyindoleacetic acid and melatonin levels in patients with either Huntington's disease or chronic brain injury by Christofides, J., Bridel, M., Egerton, M., Mackay, G. M., Forrest, C. M., Stoy, N., Darlington, L. G., Stone, T. W.

“…Following a study of oxidative tryptophan metabolism to kynurenines, we have now analysed the blood of patients with either Huntington's disease or traumatic…”
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Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine by Forrest, C.M, McNair, K, Pisar, M, Khalil, O.S, Darlington, L.G, Stone, T.W

“…Highlights • Prenatal kynurenine or kynurenine monoxygenase deletion reduced adult hippocampal LTP. • There were no changes in expression of NMDA receptors or…”
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Tryptophan loading induces oxidative stress by Forrest, C M, Mackay, G M, Stoy, N, Egerton, M, Christofides, J, Stone, T W, Darlington, L G

“…In previous studies tryptophan loads have been administered to human subjects in order to raise central levels of 5-hydroxytryptamine (5HT) and assess the…”
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Altered kynurenine metabolism correlates with infarct volume in stroke by Darlington, L. G., Mackay, G. M., Forrest, C. M., Stoy, N., George, C., Stone, T. W.

“…Inflammation and oxidative stress are involved in brain damage following stroke, and tryptophan oxidation along the kynurenine pathway contributes to the…”
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Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway by Forrest, C.M, Khalil, O.S, Pisar, M, McNair, K, Kornisiuk, E, Snitcofsky, M, Gonzalez, N, Jerusalinsky, D, Darlington, L.G, Stone, T.W

“…Highlights • An inhibitor of kynurenine-3-monoxygenase was administered to pregnant female rats. • Adult offspring at postnatal day 60 (P60) showed alterations…”
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Modulation of cytokine release by purine receptors in patients with rheumatoid arthritis by FORREST, C. M, HARMAN, G, MCMILLAN, R. B, STOY, N, STONE, T. W, DARLINGTON, L. G

“…Since adenosine receptors are known to modulate the release of some inflammatory mediators in control subjects, we have examined the effects of the mixed A1…”
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Tryptophan, adenosine, neurodegeneration and neuroprotection by Stone, T W, Forrest, C M, Mackay, G M, Stoy, N, Darlington, L G

“…This review summarises the potential contributions of two groups of compounds to cerebral dysfunction and damage in metabolic disease. The kynurenines are…”
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Purine Modulation of Cytokine Release During Diuretic Therapy of Rheumatoid Arthritis by Forrest, C. M., Harman, G., McMillan, R. B., Rana, C., Shaw, S., Stone, T. W., Stoy, N., Darlington, L. G.

“…Since free radicals are implicated in rheumatoid arthritis (RA) and since uric acid is a free radical scavenger, we examined the effects of treating RA…”
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Environmental and microbial influence on chemistry and dolomite formation in an ancient lake, Green River Formation (Eocene), Uinta Basin, Utah, U.S.A by Pommer, Maxwell, Sarg, J. Frederick, McFarlin, Forrest

“…Integrated stratigraphic, petrographic, and geochemical data allow interpretation of biogeochemical and mineralization processes in paleoenvironmental context…”
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Purine Metabolism and Clinical Status of Patients with Rheumatoid Arthritis Treated with Dipyridamole by Forrest, C. M., Stone, T. W., Mackay, G. M., Oxford, L., Stoy, N., Harman, G., Darlington, L. G.

“…The anti-inflammatory activities of methotrexate and sulphasalazine may be mediated by increases in endogenous adenosine levels. Since the vascular protective…”
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Familial Poverty, Family Allowances, and the Normative Family Structure in Britain, 1917-1945 by Forrest, Colleen Margaret

“…In 1945, the Family Allowances Act was incorporated into law. The family allowances scheme depended on the maintenance of a normative family structure and a…”
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Levels of lipid peroxidation products in a chronic inflammatory disorder by Deaney, C L, Feyi, K, Forrest, C M, Freeman, A, Harman, G, McDonald, M S, Petrie, A, Shaw, S J, Stone, T W, Stoy, N, Darlington, L G

“…We have examined the plasma levels of the lipid peroxidation products 4-hydroxy-nonenal and malondialdehyde in a carefully controlled study of age and…”
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CHANGES IN SYNAPTIC TRANSMISSION AND PROTEIN EXPRESSION IN THE BRAINS OF ADULT OFFSPRING AFTER PRENATAL INHIBITION OF THE KYNURENINE PATHWAY by FORREST, C. M, KHALIL, O. S, PISAR, M, MCNAIR, K, KORNISIUK, E, SNITCOFSKY, M, GONZALEZ, N, JERUSALINSKY, D, DARLINGTON, L. G, STONE, T. W

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Tryptophan metabolites and brain disorders by Stone, Trevor W, Mackay, Gillian M, Forrest, Caroline M, Clark, Catherine J, Darlington, L Gail

“…Tryptophan is metabolised primarily along the kynurenine pathway, of which two components are now known to have marked effects on neurons in the central…”
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Levels of purine, kynurenine and lipid peroxidation products in patients with inflammatory bowel disease by Forrest, Caroline M, Gould, Stuart R, Darlington, L Gail, Stone, Trevor W

“…The factors affecting gut activity in inflammatory bowel disease are unclear, but purines and kynurenines may be involved in the regulation of neuronal…”
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Kynurenine and neopterin levels in patients with rheumatoid arthritis and osteoporosis during drug treatment by Forrest, Caroline M, Kennedy, Alan, Stone, Trevor W, Stoy, Nicholas, Darlington, L Gail

“…The kynurenine pathway from tryptophan generates compounds which can act on glutamate receptors in peripheral tissues or modulate free radical activity. We…”
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Purine, kynurenine, neopterin and lipid peroxidation levels in inflammatory bowel disease by Forrest, Caroline M, Youd, Philippa, Kennedy, Alan, Gould, Stuart R, Darlington, L Gail, Stone, Trevor W

“…The kynurenine metabolites of tryptophan may be involved in the regulation of neuronal activity and thus gut motility and secretion. We have now performed a…”
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