Search Results - "Foroud, Tatiana"

Neurology Individualized Medicine: When to Use Next-Generation Sequencing Panels by Klein, Christopher J., MD, Foroud, Tatiana M., PhD

“…Abstract Next-generation sequencing (NGS) is increasingly being applied to clinical testing. This practice is predicted to grow especially in neurology clinics…”
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Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families by Cruchaga, Carlos, Haller, Gabe, Chakraverty, Sumitra, Mayo, Kevin, Vallania, Francesco L M, Mitra, Robi D, Faber, Kelley, Williamson, Jennifer, Bird, Tom, Diaz-Arrastia, Ramon, Foroud, Tatiana M, Boeve, Bradley F, Graff-Radford, Neill R, St Jean, Pamela, Lawson, Michael, Ehm, Margaret G, Mayeux, Richard, Goate, Alison M

“…Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked to familial early onset forms of dementia. Mutation screening in these…”
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Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE by Wijsman, Ellen M, Pankratz, Nathan D, Choi, Yoonha, Rothstein, Joseph H, Faber, Kelley M, Cheng, Rong, Lee, Joseph H, Bird, Thomas D, Bennett, David A, Diaz-Arrastia, Ramon, Goate, Alison M, Farlow, Martin, Ghetti, Bernardino, Sweet, Robert A, Foroud, Tatiana M, Mayeux, Richard

“…Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly. The National Institute of Aging-Late Onset Alzheimer's Disease Family…”
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Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans by Saykin, Andrew J, Shen, Li, Yao, Xiaohui, Kim, Sungeun, Nho, Kwangsik, Risacher, Shannon L, Ramanan, Vijay K, Foroud, Tatiana M, Faber, Kelley M, Sarwar, Nadeem, Munsie, Leanne M, Hu, Xiaolan, Soares, Holly D, Potkin, Steven G, Thompson, Paul M, Kauwe, John S.K, Kaddurah-Daouk, Rima, Green, Robert C, Toga, Arthur W, Weiner, Michael W

“…Abstract Introduction Genetic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) have been crucial in advancing the understanding of Alzheimer's…”
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Hippocampal-subfield microstructures and their relation to plasma biomarkers in Alzheimer's disease by Shahid, Syed Salman, Wen, Qiuting, Risacher, Shannon L, Farlow, Martin R, Unverzagt, Frederick W, Apostolova, Liana G, Foroud, Tatiana M, Zetterberg, Henrik, Blennow, Kaj, Saykin, Andrew J, Wu, Yu Chien

“…Hippocampal subfields exhibit differential vulnerabilities to Alzheimer's disease-associated pathology including abnormal accumulation of amyloid-β deposition…”
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Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD by McCarthy, Neil, Wetherill, Leah, Lovely, C Ben, Swartz, Mary E, Foroud, Tatiana M, Eberhart, Johann K

“…Human birth defects are highly variable and this phenotypic variability can be influenced by both the environment and genetics. However, the synergistic…”
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A novel SNCA E83Q mutation in a case of dementia with Lewy bodies and atypical frontotemporal lobar degeneration by Kapasi, Alifiya, Brosch, Jared R., Nudelman, Kelly N., Agrawal, Sonal, Foroud, Tatiana M., Schneider, Julie A.

“…In this case report, we discuss a patient presenting with parkinsonism followed by a non‐amnestic dementia with aphasic clinical features, as well as frontal…”
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Biomarkers of neurodegeneration and glial activation validated in Alzheimer’s disease assessed in longitudinal cerebrospinal fluid samples of Parkinson’s disease by Bartl, Michael, Dakna, Mohammed, Galasko, Douglas, Hutten, Samantha J, Foroud, Tatiana, Quan, Marian, Marek, Kenneth, Siderowf, Andrew, Franz, Jonas, Trenkwalder, Claudia, Mollenhauer, Brit

“…Aim Several pathophysiological processes are involved in Parkinson’s disease (PD) and could inform in vivo biomarkers. We assessed an established biomarker…”
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Persistent changes in stress-regulatory genes in pregnant woman or a child with prenatal alcohol exposure by Sarkar, Dipak K., Gangisetty, Omkaram, Wozniak, Jeffrey R., Eckerle, Judith K., Georgieff, Michael K., Foroud, Tatiana M, Wetherill, Leah, Wertelecki, Wladimir, Chambers, Christina D., Riley, Edward, Zymak-Zakutnya, Natalya, Yevtushok, Lyubov

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Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non‐Ashkenazi Jewish ancestry by Lee, Annie J., Wang, Yuanjia, Alcalay, Roy N., Mejia‐Santana, Helen, Saunders‐Pullman, Rachel, Bressman, Susan, Corvol, Jean‐Christophe, Brice, Alexis, Lesage, Suzanne, Mangone, Graziella, Tolosa, Eduardo, Pont‐Sunyer, Claustre, Vilas, Dolores, Schüle, Birgitt, Kausar, Farah, Foroud, Tatiana, Berg, Daniela, Brockmann, Kathrin, Goldwurm, Stefano, Siri, Chiara, Asselta, Rosanna, Ruiz‐Martinez, Javier, Mondragón, Elisabet, Marras, Connie, Ghate, Taneera, Giladi, Nir, Mirelman, Anat, Marder, Karen

“…ABSTRACT Background Penetrance estimates of the leucine‐rich repeat kinase 2 (LRRK2) p.G2019S mutation for PD vary widely (24%‐100%). The p.G2019S penetrance…”
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Genome‐wide Association Study and Meta‐analysis on Alcohol‐Associated Liver Cirrhosis Identifies Genetic Risk Factors by Schwantes‐An, Tae‐Hwi, Darlay, Rebecca, Mathurin, Philippe, Masson, Steven, Liangpunsakul, Suthat, Mueller, Sebastian, Aithal, Guruprasad P., Eyer, Florian, Gleeson, Dermot, Thompson, Andrew, Muellhaupt, Beat, Stickel, Felix, Soyka, Michael, Goldman, David, Liang, Tiebing, Lumeng, Lawrence, Pirmohamed, Munir, Nalpas, Bertrand, Jacquet, Jean‐Marc, Moirand, Romain, Nahon, Pierre, Naveau, Sylvie, Perney, Pascal, Botwin, Greg, Haber, Paul S., Seitz, Helmut K., Day, Christopher P., Foroud, Tatiana M., Daly, Ann K., Cordell, Heather J., Whitfield, John B., Morgan, Timothy R., Seth, Devanshi

“…Background and Aims Only a minority of heavy drinkers progress to alcohol‐associated cirrhosis (ALC). The aim of this study was to identify common genetic…”
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Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence by Andersen, Allan M, Pietrzak, Robert H, Kranzler, Henry R, Ma, Li, Zhou, Hang, Liu, Xiaoming, Kramer, John, Kuperman, Samuel, Edenberg, Howard J, Nurnberger, Jr, John I, Rice, John P, Tischfield, Jay A, Goate, Alison, Foroud, Tatiana M, Meyers, Jacquelyn L, Porjesz, Bernice, Dick, Danielle M, Hesselbrock, Victor, Boerwinkle, Eric, Southwick, Steven M, Krystal, John H, Weissman, Myrna M, Levinson, Douglas F, Potash, James B, Gelernter, Joel, Han, Shizhong

“…Major depressive disorder (MDD) and alcohol dependence (AD) are heritable disorders with significant public health burdens, and they are frequently comorbid…”
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Persistent Changes in Stress‐Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol by Sarkar, Dipak K., Gangisetty, Omkaram, Wozniak, Jeffrey R., Eckerle, Judith K., Georgieff, Michael K., Foroud, Tatiana M., Wetherill, Leah, Wertelecki, Wladimir, Chambers, Christina D., Riley, Edward, Zymak‐Zakutnya, Natalya, Yevtushok, Lyubov

“…Background We have recently shown that binge or heavy levels of alcohol drinking increase deoxyribonucleic acid (DNA) methylation and reduce gene expression of…”
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Identification of TMEM230 mutations in familial Parkinson's disease by Deng, Han-Xiang, Shi, Yong, Yang, Yi, Ahmeti, Kreshnik B, Miller, Nimrod, Huang, Cao, Cheng, Lijun, Zhai, Hong, Deng, Sheng, Nuytemans, Karen, Corbett, Nicola J, Kim, Myung Jong, Deng, Hao, Tang, Beisha, Yang, Ziquang, Xu, Yanming, Chan, Piu, Huang, Bo, Gao, Xiao-Ping, Song, Zhi, Liu, Zhenhua, Fecto, Faisal, Siddique, Nailah, Foroud, Tatiana, Jankovic, Joseph, Ghetti, Bernardino, Nicholson, Daniel A, Krainc, Dimitri, Melen, Onur, Vance, Jeffery M, Pericak-Vance, Margaret A, Ma, Yong-Chao, Rajput, Ali H, Siddique, Teepu

“…Han-Xiang Deng and colleagues identify TMEM230 mutations in Lewy body–confirmed Parkinson's disease. They also show evidence that disease-associated TMEM230…”
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Harnessing diversity to study Alzheimer's disease: A new iPSC resource from the NIH CARD and ADNI by Screven, Laurel A, Pantazis, Caroline B, Andersh, Katherine M, Hong, Samantha, Vitale, Dan, Lara, Erika, Ku, Ray Yueh, Heutink, Peter, Meyer, Jason, Faber, Kelley, Nho, Kwangsik, Saykin, Andrew J, Foroud, Tatiana M, Nalls, Mike A, Blauwendraat, Cornelis, Singleton, Andrew, Narayan, Priyanka S

“…The iDA Project (iPSCs to Study Diversity in Alzheimer's and Alzheimer's Disease-related Dementias) is generating 200 induced pluripotent stem cell lines from…”
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A description of the methods of the Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be (nuMoM2b) by Haas, David M., MD, MS, Parker, Corette B., DrPH, Wing, Deborah A., MD, Parry, Samuel, MD, Grobman, William A., MD, MBA, Mercer, Brian M., MD, Simhan, Hyagriv N., MD, Hoffman, Matthew K., MD, Silver, Robert M., MD, Wadhwa, Pathik, MD, PhD, Iams, Jay D., MD, Koch, Matthew A., MD, PhD, Caritis, Steve N., MD, Wapner, Ronald J., MD, Esplin, M. Sean, MD, Elovitz, Michal A., MD, Foroud, Tatiana, PhD, Peaceman, Alan M., MD, Saade, George R., MD, Willinger, Marian, PhD, Reddy, Uma M., MD, MPH

“…Objective The primary aim of the “Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be” is to determine maternal characteristics, which include…”
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Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research by O'Bryant, Sid E, Gupta, Veer, Henriksen, Kim, Edwards, Melissa, Jeromin, Andreas, Lista, Simone, Bazenet, Chantal, Soares, Holly, Lovestone, Simon, Hampel, Harald, Montine, Thomas, Blennow, Kaj, Foroud, Tatiana, Carrillo, Maria, Graff-Radford, Neill, Laske, Christoph, Breteler, Monique, Shaw, Leslie, Trojanowski, John Q, Schupf, Nicole, Rissman, Robert A, Fagan, Anne M, Oberoi, Pankaj, Umek, Robert, Weiner, Michael W, Grammas, Paula, Posner, Holly, Martins, Ralph

“…Abstract The lack of readily available biomarkers is a significant hindrance toward progressing to effective therapeutic and preventative strategies for…”
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Systematic rare variant analyses identify RAB32 as a susceptibility gene for familial Parkinson’s disease by Hop, Paul J., Lai, Dongbing, Keagle, Pamela J., Baron, Desiree M., Kenna, Brendan J., Kooyman, Maarten, Shankaracharya, Halter, Cheryl, Straniero, Letizia, Asselta, Rosanna, Bonvegna, Salvatore, Soto-Beasley, Alexandra I., Wszolek, Zbigniew K., Uitti, Ryan J., Isaias, Ioannis Ugo, Pezzoli, Gianni, Ticozzi, Nicola, Ross, Owen A., Veldink, Jan H., Foroud, Tatiana M., Kenna, Kevin P., Landers, John E.

“…Despite substantial progress, causal variants are identified only for a minority of familial Parkinson’s disease (PD) cases, leaving high-risk pathogenic…”
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Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases by Kapoor, Manav, Chao, Michael J., Johnson, Emma C., Novikova, Gloriia, Lai, Dongbing, Meyers, Jacquelyn L., Schulman, Jessica, Nurnberger, John I., Porjesz, Bernice, Liu, Yunlong, Foroud, Tatiana, Edenberg, Howard J., Marcora, Edoardo, Agrawal, Arpana, Goate, Alison

“…Identification of causal variants and genes underlying genome-wide association study (GWAS) loci is essential to understand the biology of alcohol use disorder…”
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Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199 by Schneider, Bryan P, Li, Lang, Radovich, Milan, Shen, Fei, Miller, Kathy D, Flockhart, David A, Jiang, Guanglong, Vance, Gail, Gardner, Laura, Vatta, Matteo, Bai, Shaochun, Lai, Dongbing, Koller, Daniel, Zhao, Fengmin, O'Neill, Anne, Smith, Mary Lou, Railey, Elda, White, Carol, Partridge, Ann, Sparano, Joseph, Davidson, Nancy E, Foroud, Tatiana, Sledge, Jr, George W

“…Taxane-induced peripheral neuropathy (TIPN) is an important survivorship issue for many cancer patients. Currently, there are no clinically implemented…”
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