Search Results - "Forootan, Shiva S."

Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration by Chan, Benjamin K.Y., Elmasry, Mohamed, Forootan, Shiva S., Russomanno, Giusy, Bunday, Tobias M., Zhang, Fang, Brillant, Nathalie, Starkey Lewis, Philip J., Aird, Rhona, Ricci, Emanuele, Andrews, Timothy D., Sison‐Young, Rowena L., Schofield, Amy L., Fang, Yongxiang, Lister, Adam, Sharkey, Jack W., Poptani, Harish, Kitteringham, Neil R., Forbes, Stuart J., Malik, Hassan Z., Fenwick, Stephen W., Park, B. Kevin, Goldring, Christopher E., Copple, Ian M.

“…Background and Aims The transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) regulates an array of cytoprotective genes, yet studies in…”
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Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case–control study by Grove, Jane I., Stephens, Camilla, Lucena, M. Isabel, Andrade, Raúl J., Weber, Sabine, Gerbes, Alexander, Bjornsson, Einar S., Stirnimann, Guido, Daly, Ann K., Hackl, Matthias, Khamina-Kotisch, Kseniya, Marin, Jose J. G., Monte, Maria J., Paciga, Sara A., Lingaya, Melanie, Forootan, Shiva S., Goldring, Christopher E. P., Poetz, Oliver, Lombaard, Rudolf, Stege, Alexandra, Bjorrnsson, Helgi K., Robles-Diaz, Mercedes, Li, Dingzhou, Tran, Thi Dong Binh, Ramaiah, Shashi K., Samodelov, Sophia L., Kullak-Ublick, Gerd A., Aithal, Guruprasad P.

“…Abstract A lack of biomarkers that detect drug-induced liver injury (DILI) accurately continues to hinder early- and late-stage drug development and remains a…”
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Prognostic significance of osteopontin expression in human prostate cancer by Forootan, Shiva S., Foster, Christopher S., Aachi, Vijay R., Adamson, Janet, Smith, Paul H., Lin, Ke, Ke, Youqiang

“…To test the hypothesis that expression of osteopontin (OPN), an integrin‐binding glycoprotein, can independently predict the potential aggressiveness of…”
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Increased Expression of Id Family Proteins in Small Cell Lung Cancer and its Prognostic Significance by KAMALIAN, Laleh, GOSNEY, John R, FOROOTAN, Shiva S, FOSTER, Christopher S, BAO, Zheng Z, BEESLEY, Carol, YOUQIANG KE

“…Purpose: To study the molecular pathology of human small cell lung cancer (SCLC), molecular biology approaches were used to identify genes involved in…”
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Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer by Forootan, Shiva S., MD, PhD, Wong, Yong-Chuan, PhD, Dodson, Andrew, BSc, MSc, Wang, Xianghong, PhD, Lin, Ke, PhD, Smith, Paul H., PhD, Foster, Christopher S., MD, PhD, DSc, FASCP, FRCPath, Ke, Youqiang, DVM, PhD

“…Summary The levels of Id-1 (inhibitor of DNA binding or inhibitor of cell differentiation) expression in a series of prostate cell lines and in an archival set…”
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Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter by Forootan, Farzad S, Forootan, Shiva S, Gou, Xiaojun, Yang, Jin, Liu, Bichong, Chen, Danqing, Al Fayi, Majed Saad, Al-Jameel, Waseem, Rudland, Philip S, Hussain, Syed A, Ke, Youqiang

“…In previous work, it is suggested that the excessive amount of fatty acids transported by FABP5 may facilitate the malignant progression of prostate cancer…”
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The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance by Al Fayi, Majed Saad, Gou, Xiaojun, Forootan, Shiva S, Al-Jameel, Waseem, Bao, Zhengzheng, Rudland, Philip R, Cornford, Philip A, Hussain, Syed A, Ke, Youqiang

“…In contrast to numerous studies conducted to investigate the crucial role of fatty acid binding protein 5 (FABP5) in prostate cancer, investigations on the…”
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Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity by Forootan, Shiva S., Mutter, Fiona E., Kipar, Anja, Iwawaki, Takao, Francis, Ben, Goldring, Christopher E., Park, B. Kevin, Copple, Ian M.

“…The transcription factor Nrf2 coordinates an adaptive response to chemical and oxidative stress characterised by the upregulated expression of cytoprotective…”
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Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5 by Al-Jameel, Waseem, Gou, Xiaojun, Forootan, Shiva S, Al Fayi, Majed Saad, Rudland, Philip S, Forootan, Farzad S, Zhang, Jiacheng, Cornford, Philip A, Hussain, Syed A, Ke, Youqiang

“…Castration resistant-prostate cancer is largely impervious to feather hormonal therapy and hence the outlook for patients is grim. Here we use an approach to…”
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The expression of C-FABP and PPARγ and their prognostic significance in prostate cancer by FOROOTAN, FARZAD S, FOROOTAN, SHIVA S, MALKI, MOHAMMED I, CHEN, DANQING, LI, GANDI, LIN, KE, RUDLAND, PHILIP S, FOSTER, CHRISTOPHER S, KE, YOUQIANG

“…The purpose of this study was to test the hypothesis that cooperative interaction between cutaneous fatty acid-binding protein (C-FABP) and peroxisome…”
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118: Interaction of C-FABP and PPARS in prostate cancer by Seyed Forootan, F, Seyed Forootan Shiva, S, Ke, Y

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A novel cutaneous Fatty Acid-binding protein-related signaling pathway leading to malignant progression in prostate cancer cells by Bao, Zhengzheng, Malki, Mohammad I, Forootan, Shiva S, Adamson, Janet, Forootan, Farzad S, Chen, Danqing, Foster, Christopher S, Rudland, Philip S, Ke, Youqiang

“…Cutaneous fatty acid-binding protein (C-FABP), a cancer promoter and metastasis inducer, is overexpressed in the majority of prostatic carcinomas…”
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Increased expression of Id1 and Id3 promotes tumorigenicity by enhancing angiogenesis and suppressing apoptosis in small cell lung cancer by Chen, Danqing, Forootan, Shiva S, Gosney, John R, Forootan, Farzad S, Ke, Youqiang

“…Constant deregulation of Id1 and Id3 has been implicated in a wide range of carcinomas. However, underlying molecular evidence for the joint role of Id1 and…”
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Expression of cutaneous fatty acid-binding protein (C-FABP) in prostate cancer : Potential prognostic marker and target for tumourigenicity-suppression by MORGAN, Elwin A, FOROOTAN, Shiva S, ADAMSON, Janet, FOSTER, Christopher S, FUJII, Hiroshi, IGARASHI, Michihiro, BEESLEY, Carol, SMITH, Paul H, YOUQIANG KE

“…C-FABP or E-FABP is a metastasis inducing gene over expressed in human prostate carcinomas. To study its prognostic significance, an archival set of prostate…”
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Atelocollagen-delivered siRNA targeting the FABP5 gene as an experimental therapy for prostate cancer in mouse xenografts by FOROOTAN, Shiva S, BAO, Zheng Z, FOROOTAN, Farzad S, KAMALIAN, Laleh, YU ZHANG, BEE, Alix, FOSTER, Christopher S, YOUQIANG KE

“…The gene FABP5 encodes cutaneous fatty acid binding protein (C-FABP) that is up-regulated in prostate cancer where it acts as a putative oncogene. To test the…”
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Suppressing tumourigenicity of prostate cancer cells by inhibiting osteopontin expression by YU ZHANG, FOROOTAN, Shiva S, KAMALIAN, Laleh, BAO, Zheng Z, MALKI, Mohammed I, FOSTER, Christopher S, YOUQIANG KE

“…Expression of osteopontin (OPN) is increased in prostate cancer cells. The possibility of utilising the increased OPN as a target to suppress the…”
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Inhibition of tumourigenicity of small cell lung cancer cells by suppressing Id3 expression by KAMALIAN, Laleh, FOROOTAN, Shiva S, BAO, Zheng Z, YU ZHANG, GOSNEY, John R, FOSTER, Christopher S, YOUQIANG KE

“…Id3 is over-expressed in small cell lung cancer (SCLC). To test whether the tumourigenicity of SCLC cells can be inhibited by suppressing Id3 expression, we…”
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Correction: Inhibitor SBFI26 suppresses the malignant progression of castration-resistant PC3-M cells by competitively binding to oncogenic FABP5 by Al-Jameel, Waseem, Gou, Xiaojun, Forootan, Shiva S., Fayi, Majed Saad Al, Rudland, Philip S., Forootan, Farzad S., Zhang, Jiacheng, Cornford, Philip A., Hussain, Syed A., Ke, Youqiang

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Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol by Setiabudi, Wega, Hungerford, Daniel, Subramaniam, Krishanthi, Vaselli, Natasha Marcella, Shaw, Victoria E, Wilton, Moon, Vivancos, Roberto, Aston, Stephen, Platt, Gareth, Moitt, Tracy, Jones, Ashley P, Gabbay, Mark, Buchan, Iain, Carrol, Enitan D, Iturriza-Gomara, Miren, Solomon, Tom, Greenhalf, William, Naisbitt, Dean J, Adams, Emily R, Cunliffe, Nigel A, Turtle, Lance, French, Neil

“…IntroductionThe emergence and rapid spread of COVID-19 have caused widespread and catastrophic public health and economic impact, requiring governments to…”
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Abstract B60: Suppressing malignant progression of prostate cancer by inhibiting expression of OPN and S100A4 by Zhang, Yu, Forootan, Shiva S., Foster, Christopher, Ke, Youqiang

“…Abstract The potential of using OPN and S100A4 as therapeutic targets has been tested in this study. Constructs expressing short silencing RNAs targeting OPN…”
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