Search Results - "Forno, L. S."

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure by Langston, J. W., Forno, L. S., Tetrud, J., Reeves, A. G., Kaplan, J. A., Karluk, D.

“…This report provides the first detailed neuropathological study of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced parkinsonism in humans. All 3…”
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Neuropathology of Parkinsonʼs Disease by Forno, Lysia S

“…Keywords: Basal ganglia, Cytoskeleton, Lewy bodies, Parkinsonism, Substantia nigra…”
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Hereditary form of parkinsonism--dementia by Muenter, M D, Forno, L S, Hornykiewicz, O, Kish, S J, Maraganore, D M, Caselli, R J, Okazaki, H, Howard, Jr, F M, Snow, B J, Calne, D B

“…In four generations of a family, 13 members were afflicted with an autosomal dominant disorder characterized by young age at onset, early weight loss, and…”
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Absence of mutations in the coding region of the α-synuclein gene in pathologically proven Parkinson's disease by CHAN, P, JIANG, X, FORNO, L. S, DI MONTE, D. A, TANNER, C. M, LANGSTON, J. W

“…A missense mutation of the alpha-synuclein gene has been associated with parkinsonism in a large Italian kindred. Recently, alpha-synuclein was also identified…”
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Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease by Murphy, GM, Jr, Forno, LS, Ellis, WG, Nochlin, D, Levy-Lahad, E, Poorkaj, P, Bird, TD, Jiang, Z, Cordell, B

“…Mutations in the presenilin (PS)-1 and PS-2 genes have been shown to be linked with the development of Alzheimer's disease (AD). We examined Alzheimer's brain…”
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No association between the alpha 1-antichymotrypsin A allele and Alzheimer's disease by MURPHY, G. M, SULLIVAN, E. V, GALLAGHER-THOMPSON, D, THOMPSON, L. W, VAN DUIJN, C. M, FORNO, L. S, ELLIS, W. G, JAGUST, W. J, YESAVAGE, J, TINKLENBERG, J. R

“…The alpha 1-antichymotrypsin (ACT) A allele was recently associated with Alzheimer's disease (AD), and the ACT AA genotype was reported to be more frequent in…”
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P3 beta-amyloid peptide has a unique and potentially pathogenic immunohistochemical profile in Alzheimer's disease brain by Higgins, LS, Murphy, GM, Jr, Forno, LS, Catalano, R, Cordell, B

“…The presence of beta-amyloid in brain tissue is characteristic of Alzheimer's disease (AD). A naturally occurring derivative of the beta-amyloid peptide, p3,…”
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Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra by Ricaurte, G A, Irwin, I, Forno, L S, DeLanney, L E, Langston, E, Langston, J W

“…This study assessed the influence of aging on substantia nigra degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Extensive neuronal…”
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Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey by Langston, J W, Forno, L S, Rebert, C S, Irwin, I

“…1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) was administered via the intraperitoneal route to squirrel monkeys. Akinesia, rigidity and hypophonia were…”
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Pargyline Prevents MPTP-Induced Parkinsonism in Primates by Langston, J. William, Irwin, Ian, Langston, Elizabeth B., Forno, Lysia S.

“…1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin which produces permanent parkinsonism in human and nonhuman primates. Treatment of squirrel…”
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Development of a monoclonal antibody specific for the COOH-terminal of beta-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders by Murphy, GM, Jr, Forno, LS, Higgins, L, Scardina, JM, Eng, LF, Cordell, B

“…The beta-amyloid peptide (beta AP) has been characterized by protein sequencing techniques as a 39-43 amino acid protein with heterogeneous COOH-termini…”
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Autopsy-proven progressive supranuclear palsy in two siblings by TETRUD, J. W, GOLBE, L. I, FORNO, L. S, FARMER, P. M

“…Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that is generally considered to be nonfamilial. We report a brother and sister with…”
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Long-term effects of chronic methamphetamine administration in rhesus monkeys by Woolverton, W L, Ricaurte, G A, Forno, L S, Seiden, L S

“…Biochemical and neuropathological effects of exposure to a high dose regimen of methamphetamine were evaluated in rhesus monkeys approximately 4 years after…”
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Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys by Forno, L S, Langston, J W, DeLanney, L E, Irwin, I, Ricaurte, G A

“…Systemic administration of the recently discovered neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces severe clinical parkinsonism and…”
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1-Methyl-4-phenylpyridinium ion (MPP+): identification of a metabolite of MPTP, a toxin selective to the substantia nigra by Langston, J W, Irwin, I, Langston, E B, Forno, L S

“…MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a newly described neurotoxin which selectively destroys cells in the substantia nigra when administered…”
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No neuropathologic evidence for an increased frequency of Alzheimer's disease among elderly schizophrenics by Murphy, Greer M., Lim, Kelvin O., Wieneke, Mary, Ellis, William G., Forno, Lysia S., Hoff, Anne L., Nordahl, Thomas

“…There is currently controversy as to the frequency of Alzheimer's disease (AD) in elderly persons with schizophrenia. Several studies have reported an…”
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Induction of anti-myelin antibodies in EAE and their possible role in demyelination by Sadler, R H, Sommer, M A, Forno, L S, Smith, M E

“…Experimental allergic encephalomyelitis is characterized by invasion of lymphocytes and macrophages into the central nervous system resulting in inflammation,…”
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Fate of nigrostriatal neurons in young mature mice given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: a neurochemical and morphological reassessment by Ricaurte, G A, Langston, J W, Delanney, L E, Irwin, I, Peroutka, S J, Forno, L S

“…The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on nigrostriatal dopaminergic neurons in the mouse was re-examined in view of recent…”
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EAE cerebrospinal fluid augments in vitro phagocytosis and metabolism of CNS myelin by macrophages by Sommer, M A, Forno, L S, Smith, M E

“…Previous studies from this laboratory have shown that CNS myelin is phagocytized and metabolized by cultured rat macrophages to a much larger extent when…”
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Unfavorable outcome of adrenal medullary transplant for Parkinson's disease by FORNO, L. S, LANGSTON, J. W

“…A 45-year-old woman with moderately severe parkinsonism underwent adrenal medullary autograft to the brain. The operation was performed in Mexico City. There…”
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