Search Results - "Fornis, Lorelenn"

Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19 by Bai, Xiyuan, Buckle, Ashley M., Vladar, Eszter K., Janoff, Edward N., Khare, Reeti, Ordway, Diane, Beckham, David, Fornis, Lorelenn B., Majluf-Cruz, Abraham, Fugit, Randolph V., Freed, Brian M., Kim, Soohyun, Sandhaus, Robert A., Chan, Edward D.

“…The cell surface serine protease Transmembrane Protease 2 (TMPRSS2) is required to cleave the spike protein of SARS-CoV-2 for viral entry into cells. We…”
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Author Correction: Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19 by Bai, Xiyuan, Buckle, Ashley M., Vladar, Eszter K., Janoff, Edward N., Khare, Reeti, Ordway, Diane, Beckham, David, Fornis, Lorelenn B., Majluf-Cruz, Abraham, Fugit, Randolph V., Freed, Brian M., Kim, Soohyun, Sandhaus, Robert A., Chan, Edward D.

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Analysis of alpha‐1‐antitrypsin (AAT)‐regulated, glucocorticoid receptor‐dependent genes in macrophages reveals a novel host defense function of AAT by Bai, Xiyuan, Gao, Junfeng, Guan, Xiaoyu, Narum, Drew E., Fornis, Lorelenn B., Griffith, David E., Gao, Bifeng, Sandhaus, Robert A., Huang, Hua, Chan, Edward D.

“…Alpha‐1‐antitrypsin (AAT) plays a homeostatic role in attenuating excessive inflammation and augmenting host defense against microbes. We demonstrated…”
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Ex vivo and in vivo evidence that cigarette smoke-exposed T regulatory cells impair host immunity against Mycobacterium tuberculosis by Bai, Xiyuan, Verma, Deepshikha, Garcia, Cindy, Musheyev, Ariel, Kim, Kevin, Fornis, Lorelenn, Griffith, David E, Li, Li, Whittel, Nicholas, Gadwa, Jacob, Ohanjanyan, Tamara, Eggleston, Matthew J, Galvan, Manuel, Freed, Brian M, Ordway, Diane, Chan, Edward D

“…A strong epidemiologic link exists between cigarette smoke (CS) exposure and susceptibility to tuberculosis (TB). Macrophage and murine studies showed that CS…”
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α1-Antitrypsin Binds to the Glucocorticoid Receptor with Anti-Inflammatory and Antimycobacterial Significance in Macrophages by Bai, Xiyuan, Bai, An, Tomasicchio, Michele, Hagman, James R, Buckle, Ashley M, Gupta, Arnav, Kadiyala, Vineela, Bevers, Shaun, Serban, Karina A, Kim, Kevin, Feng, Zhihong, Spendier, Kathrin, Hagen, Guy, Fornis, Lorelenn, Griffith, David E, Dzieciatkowska, Monika, Sandhaus, Robert A, Gerber, Anthony N, Chan, Edward D

“…α1-Antitrypsin (AAT), a serine protease inhibitor, is the third most abundant protein in plasma. Although the best-known function of AAT is irreversible…”
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Alpha-1-antitrypsin binds to the glucocorticoid receptor with anti-inflammatory and anti-mycobacterial significance in macrophages by Bai, Xiyuan, Bai, An, Tomasicchio, Michele, Hagman, James R., Buckle, Ashley M., Gupta, Arnav, Kadiyala, Vineela, Bevers, Shaun, Serban, Karina A., Kim, Kevin, Feng, Zhihong, Spendier, Kathrin, Hagen, Guy, Fornis, Lorelenn, Griffith, David E., Dzieciatkowska, Monika, Sandhaus, Robert A., Gerber, Anthony N., Chan, Edward D.

“…Alpha-1-antitrypsin (AAT), a serine protease inhibitor, is the third most abundant protein in plasma. While the best-known function of AAT is irreversible…”
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