Search Results - "Fornace Jr, Albert J."

Identification of Noninvasive Biomarkers for Alcohol-Induced Liver Disease Using Urinary Metabolomics and the Ppara-null Mouse by Manna, Soumen K, Patterson, Andrew D, Yang, Qian, Krausz, Kristopher W, Li, Henghong, Idle, Jeffrey R, Fornace Jr, Albert J, Gonzalez, Frank J

“…Alcohol-induced liver disease (ALD) is a leading cause of nonaccident-related deaths in the United States. Although liver damage caused by ALD is reversible…”
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Radioprotective Effects of ON 01210.Na upon Oral Administration by Suman, Shubhankar, Datta, Kamal, Doiron, Kathryn, Ren, Chen, Kumar, Ramesh, Taft, David R, Fornace, Jr, Albert J, Maniar, Manoj

“…ON 01210.Na (Ex-RAD), a chlorobenzylsulfone derivative was investigated for its pharmacologic and radioprotective properties when administered via oral and…”
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Serum Dyslipidemia Is Induced by Internal Exposure to Strontium-90 in Mice, Lipidomic Profiling Using a Data-Independent Liquid Chromatography–Mass Spectrometry Approach by Goudarzi, Maryam, Weber, Waylon M, Chung, Juijung, Doyle-Eisele, Melanie, Melo, Dunstana R, Mak, Tytus D, Strawn, Steven J, Brenner, David J, Guilmette, Raymond, Fornace Jr, Albert J

“…Despite considerable research into the environmental risks and biological effects of exposure to external beam γ rays, incorporation of radionuclides has…”
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DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a through the Gadd45 Protein by Tran, Hien, Brunet, Anne, Grenier, Jill M., Datta, Sandeep R., Fornace, Albert J., DiStefano, Peter S., Chiang, Lillian W., Greenberg, Michael E.

“…The signaling pathway from phosphoinositide 3-kinase to the protein kinase Akt controls organismal life-span in invertebrates and cell survival and…”
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3,3'-Diindolylmethane Enhances Tumor Regression After Radiation Through Protecting Normal Cells to Modulate Antitumor Immunity by Li, Lijun, Chen, Renxiang, Lin, Yun-Tien, Humayun, Arslon, Fornace, Albert J., Li, Heng-Hong

“…Preclinical and clinical data indicate that radiation therapy acts as an immune modifier, having both immune-stimulatory and immunosuppressive effects on the…”
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Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease by Li, Heng-Hong, Doiron, Kathryn, Patterson, Andrew D, Gonzalez, Frank J, Fornace, Jr, Albert J

“…Alcohol consumption is a major cause of liver disease in humans. The use and monitoring of biomarkers associated with early, pre-clinical stages of…”
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Loss of Oncogenic H-ras-Induced Cell Cycle Arrest and p38 Mitogen-Activated Protein Kinase Activation by Disruption of Gadd45a by Bulavin, Dmitry V., Kovalsky, Oleg, Hollander, M. Christine, Fornace, Albert J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Activating p38 MAPK: New Tricks for an Old Kinase by Mittelstadt, Paul R., Salvador, Jesús M., Fornace, Jr, Albert J., Ashwell, Jonathan D.

“…Mitogen-activated protein kinases (MAPKs) participate in signaling initiated by a wide variety of extracellular stimuli. MAPKs are most commonly activated by a…”
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Mice Lacking the p53-Effector Gene Gadd45a Develop a Lupus-Like Syndrome by Salvador, Jesus M., Hollander, M.Christine, Nguyen, Anh Thu, Kopp, Jeffrey B., Barisoni, Laura, Moore, Jodene K., Ashwell, Jonathan D., Fornace Jr, Albert J.

“…This study addresses the biological function of the p53-effector genes Gadd45a and p21 in the immune system. We find that Gadd45a is a negative regulator of T…”
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Regulation of Human Cdc25A Stability by Serine 75 Phosphorylation Is Not Sufficient to Activate a S-phase Checkpoint by Goloudina, Anastasia, Yamaguchi, Hiroshi, Chervyakova, Daria B., Appella, Ettore, Fornace, Jr, Albert J., Bulavin, Dmitry V.

“…Degradation of Cdc25A phosphatase is an ubiquitous feature of stress. There are some discrepancies in the reported roles for different phosphorylation sites in…”
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Host microbiome depletion attenuates biofluid metabolite responses following radiation exposure by Pannkuk, Evan L, Shuryak, Igor, Kot, Anika, Yun-Tien Lin, Lorreta, Li, Heng-Hong, Fornace, Jr, Albert J

“…Development of novel biodosimetry assays and medical countermeasures is needed to obtain a level of radiation preparedness in the event of malicious or…”
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Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells by Li, Heng-Hong, Hyduke, Daniel R., Chen, Renxiang, Heard, Pamela, Yauk, Carole L., Aubrecht, Jiri, Fornace Jr, Albert J.

“…The development of in vitro molecular biomarkers to accurately predict toxicological effects has become a priority to advance testing strategies for human…”
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High-LET-Radiation-Induced Persistent DNA Damage Response Signaling and Gastrointestinal Cancer Development by Kumar, Kamendra, Kumar, Santosh, Datta, Kamal, Fornace, Jr, Albert J, Suman, Shubhankar

“…Ionizing radiation (IR) dose, dose rate, and linear energy transfer (LET) determine cellular DNA damage quality and quantity. High-LET heavy ions are prevalent…”
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Low dose radiation upregulates Ras/p38 and NADPH oxidase in mouse colon two months after exposure by Kumar, Santosh, Suman, Shubhankar, Moon, Bo-Hyun, Fornace, Albert J, Datta, Kamal

“…Background Exposure to ionizing is known to cause persistent cellular oxidative stress and NADPH oxidase (Nox) is a major source of cellular oxidant…”
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White-Nose Syndrome Disrupts the Splenic Lipidome of Little Brown Bats (Myotis lucifugus) at Early Disease Stages by Pannkuk, Evan L., Dorville, Nicole A. S.-Y., Bansal, Shivani, Bansal, Sunil, Dzal, Yvonne A., Fletcher, Quinn E., Norquay, Kaleigh J. O., Fornace, Albert J., Willis, Craig K. R.

“…White-nose syndrome (WNS)-positive little brown bats (Myotis lucifugus) may exhibit immune responses including increased cytokine and pro-inflammatory mediator…”
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Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome by Laiakis, Evagelia C, Shuryak, Igor, Deziel, Annabella, Wang, Yi-Wen, Barnette, Brooke L, Yu, Yongjia, Ullrich, Robert L, Fornace, Jr, Albert J, Emmett, Mark R

“…Future space missions will include a return to the Moon and long duration deep space roundtrip missions to Mars. Leaving the protection that Low Earth Orbit…”
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Effects of High-Linear-Energy-Transfer Heavy Ion Radiation on Intestinal Stem Cells: Implications for Gut Health and Tumorigenesis by Kumar, Santosh, Suman, Shubhankar, Angdisen, Jerry, Moon, Bo-Hyun, Kallakury, Bhaskar V S, Datta, Kamal, Fornace, Jr, Albert J

“…Heavy ion radiation, prevalent in outer space and relevant for radiotherapy, is densely ionizing and poses a risk to intestinal stem cells (ISCs), which are…”
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Modulation of Fatty Acid and Bile Acid Metabolism By Peroxisome Proliferator-Activated Receptor α Protects Against Alcoholic Liver Disease by Li, Heng-Hong, Tyburski, John B., Wang, Yi-Wen, Strawn, Steve, Moon, Bo-Hyun, Kallakury, Bhaskar V. S., Gonzalez, Frank J., Fornace Jr, Albert J.

“…Background Chronic alcohol intake affects liver function and causes hepatic pathological changes. It has been shown that peroxisome proliferator‐activated…”
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Total body proton and heavy-ion irradiation causes cellular senescence and promotes pro-osteoclastogenic activity in mouse bone marrow by Kumar, Kamendra, Datta, Kamal, Fornace, Albert J., Suman, Shubhankar

“…Low-LET photon radiation-induced persistent alterations in bone marrow (BM) cells are well documented in total-body irradiated (TBI) rodents and also among…”
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A high-throughput and highly automated genotoxicity screening assay by Chen, Renxiang, Lin, Yun-Tien, Fornace, Jr, Albert J, Li, Heng-Hong

“…The increasing number of compounds under development and chemicals in commerce that require safety assessments pose a serious challenge for regulatory agencies…”
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