Search Results - "Forman, Stuart"

γ-Aminobutyric Acid Type A Receptor Subtypes and Circuit Connections in Midazolam-induced Amnesia, Sedation, and Hypnosis by Forman, Stuart A.

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Clinical and Molecular Pharmacology of Etomidate by FORMAN, Stuart A

“…This review focuses on the unique clinical and molecular pharmacologic features of etomidate. Among general anesthesia induction drugs, etomidate is the only…”
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Systematized Serendipity: Fishing Expeditions for Anesthetic Drugs and Targets by Crowder, C Michael, Forman, Stuart A

“…Most of science involves making observations, forming hypotheses, and testing those hypotheses, to form valid conclusions. However, a distinct, longstanding,…”
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Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes by Forman, Stuart A, Miller, Keith W

“…IV general anesthetics, including propofol, etomidate, alphaxalone, and barbiturates, produce important actions by enhancing γ-aminobutyric acid type A (GABAA)…”
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New Evidence of Receptor-based Pharmacology Underlying a Volatile Anesthetic Effect by Forman, Stuart A.

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Correction for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA Receptors by Ziemba, Alexis M, Forman, Stuart A

“…Pentobarbital, like propofol and etomidate, produces important general anesthetic effects through GABAA receptors. Photolabeling also indicates that…”
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Competitive Interactions Between Propofol and Diazepam: Studies in GABA A Receptors and Zebrafish by Pence, Andrea, Hoyt, Helen, McGrath, Megan, Forman, Stuart A, Raines, Douglas E

“…Although propofol is among the most commonly administered general anesthetics, its mechanism of action is not fully understood. It has been hypothesized that…”
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Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABA A receptor: In vitro and in vivo studies by McGrath, Megan, Hoyt, Helen, Pence, Andrea, Forman, Stuart A, Raines, Douglas E

“…In addition to binding to the classical high-affinity extracellular benzodiazepine binding site of the GABA receptor, some benzodiazepines occupy transmembrane…”
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Etomidate Effects on Desensitization and Deactivation of α 4 β 3 δ GABA A Receptors Inducibly Expressed in HEK293 TetR Cells by Liao, Yiwei, Liu, Xiang, Jounaidi, Youssef, Forman, Stuart A, Feng, Hua-Jun

“…Central 4 receptors are the most abundant isoform of subunit-containing extrasynaptic GABA receptors that mediate tonic inhibition. Although the amplitude of…”
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Substituted Cysteine Modification and Protection with n -Alkyl- Methanethiosulfonate Reagents Yields a Precise Estimate of the Distance between Etomidate and a Residue in Activated GABA Type A Receptors by Fantasia, Ryan J, Nourmahnad, Anahita, Halpin, Elizabeth, Forman, Stuart A

“…The anesthetic etomidate modulates synaptic 1 2/3 2 GABA receptors via binding sites located in transmembrane +/ - interfaces. Various approaches indicate that…”
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Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABA A Receptors by Shin, Daniel J, Germann, Allison L, Johnson, Alexander D, Forman, Stuart A, Steinbach, Joe Henry, Akk, Gustav

“…GABA receptors can be directly activated and potentiated by the intravenous anesthetic propofol. Previous photolabeling, modeling, and functional data have…”
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γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity by DESAI, Rooma, RUESCH, Dirk, FORMAN, Stuart A

“…Background Etomidate acts at gamma-Aminobutyric acid type A (GABAA) receptors containing beta2 or beta3, but not beta1 subunits. Mutations at beta residue 265…”
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Monod-Wyman-Changeux Allosteric Shift Analysis in Mutant α 1 β 3 γ 2L GABA A Receptors Indicates Selectivity and Crosstalk among Intersubunit Transmembrane Anesthetic Sites by Szabo, Andrea, Nourmahnad, Anahita, Halpin, Elizabeth, Forman, Stuart A

“…Propofol, etomidate, and barbiturate anesthetics are allosteric coagonists at pentameric 1 3 2 GABA receptors, modulating channel activation via four…”
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Tethering IL2 to Its Receptor IL2Rβ Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells by Jounaidi, Youssef, Cotten, Joseph F, Miller, Keith W, Forman, Stuart A

“…IL2 is an immunostimulatory cytokine for key immune cells including T cells and natural killer (NK) cells. Systemic IL2 supplementation could enhance…”
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Mechanisms of Actions of Inhaled Anesthetics by Campagna, Jason A, Miller, Keith W, Forman, Stuart A

“…“Suffering so great as I underwent cannot be expressed in words . . . but the blank whirlwind of emotion, the horror of great darkness, and the sense of…”
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Mutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anesthetics by Stewart, Deirdre S, Pierce, David W, Hotta, Mayo, Stern, Alex T, Forman, Stuart A

“…Etomidate and propofol are potent general anesthetics that act via GABAA receptor allosteric co-agonist sites located at transmembrane β+/α- inter-subunit…”
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Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels by Forman, Stuart A., Miller, Keith W.

“…Purpose The Cys-loop ligand-gated ion channel superfamily is a major group of neurotransmitter-activated receptors in the central and peripheral nervous…”
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Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors by Forman, Stuart A., Chiara, David C., Miller, Keith W.

“…General anesthetics are a heterogeneous group of small amphiphilic ligands that interact weakly at multiple allosteric sites on many pentameric ligand gated…”
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Drug-selective Anesthetic Insensitivity of Zebrafish Lacking γ-Aminobutyric Acid Type A Receptor β3 Subunits by Yang, Xiaoxuan, Jounaidi, Youssef, Mukherjee, Kusumika, Fantasia, Ryan J, Liao, Eric C, Yu, Buwei, Forman, Stuart A

“…BACKGROUND:Transgenic mouse studies suggest that γ-aminobutyric acid type A (GABAA) receptors containing β3 subunits mediate important effects of etomidate,…”
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Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site by Nourmahnad, Anahita, Stern, Alex T, Hotta, Mayo, Stewart, Deirdre S, Ziemba, Alexis M, Szabo, Andrea, Forman, Stuart A

“…BACKGROUND:γ-Aminobutyric acid type A (GABAA) receptors mediate important effects of intravenous general anesthetics. Photolabel derivatives of etomidate,…”
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