Search Results - "Forgue, S. Thomas"

Tadalafil pharmacokinetics in healthy subjects by Forgue, S. Thomas, Patterson, Beverley E., Bedding, Alun W., Payne, Christopher D., Phillips, Diane L., Wrishko, Rebecca E., Mitchell, Malcolm I.

“…Aims To characterize tadalafil plasma pharmacokinetics in healthy subjects following single and multiple doses. Methods Noncompartmental parameters were…”
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Model-based drug development : The road to quantitative pharmacology by LIPING ZHANG, SINHA, Vikram, THOMAS FORGUE, S, CALLIES, Sophie, LAN NI, PECK, Richard, ALLERHEILIGEN, Sandra R. B

“…High development costs and low success rates in bringing new medicines to the market demand more efficient and effective approaches. Identified by the FDA as a…”
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Effects of gender, age, diabetes mellitus and renal and hepatic impairment on tadalafil pharmacokinetics by Forgue, S. Thomas, Phillips, Diane L., Bedding, Alun W., Payne, Christopher D., Jewell, Hayley, Patterson, Beverley E., Wrishko, Rebecca E., Mitchell, Malcolm I.

“…Aims To evaluate the effects of gender, age, diabetes mellitus, renal and hepatic impairment on tadalafil pharmacokinetics and tolerability. Methods Six…”
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Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure by Abraham, Edward, Naum, Chris, Bandi, Venkata, Gervich, Daniel, Lowry, Stephen F, Wunderink, Richard, Schein, Roland M, Macias, William, Skerjanec, Simona, Dmitrienko, Alex, Farid, Nagy, Forgue, S Thomas, Jiang, Frank

“…OBJECTIVEConcentrations of group IIA secretory phospholipase A2, an inflammatory response mediator, are increased in the plasma of patients with sepsis and…”
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Effect of Tadalafil on Cytochrome P450 3A4-mediated Clearance: Studies in Vitro and in Vivo by Ring, Barbara J., Patterson, Beverley E., Mitchell, Malcolm I., Vandenbranden, Mark, Gillespie, Jennifer, Bedding, Alun W., Jewell, Hayley, Payne, Christopher D., Forgue, S. Thomas, Eckstein, James, Wrighton, Steven A., Phillips, Diane L.

“…Objectives Tadalafil was examined in vitro and in vivo for its ability to affect human cytochrome P450 (CYP) 3A‐mediated metabolism. Methods Reversible and…”
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Tadalafil population pharmacokinetics in patients with erectile dysfunction by TROCONIZ, Inaki F, TILLMANN, Christiane, STAAB, Alexander, RAPADO, Javier, FORGUE, S. Thomas

“…The purpose of this study was to characterize pharmacokinetics of tadalafil (Cialis) and potential sources of variability in patients with erectile dysfunction…”
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Population dose-response model for tadalafil in the treatment of male erectile dysfunction by Staab, Alexander, Tillmann, Christiane, Forgue, S Thomas, Mackie, Alison, Allerheiligen, Sandra R B, Rapado, Javier, Trocóniz, Iñaki F

“…To determine the population dose-response relationship for tadalafil during on-demand (as-needed) administration for treatment of erectile dysfunction (ED). A…”
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Pharmacokinetics of cefepime in subjects with renal insufficiency by Barbhaiya, R H, Knupp, C A, Forgue, S T, Matzke, G R, Guay, D R, Pittman, K A

“…The pharmacokinetics of intravenously administered cefepime (1000 mg over 30 minutes) were studied in 5 healthy volunteers and 20 patients with various degrees…”
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Model-Based Drug Development: The Road to Quantitative Pharmacology by Zhang, Liping, Sinha, Vikram, Forgue, S. Thomas, Callies, Sophie, Ni, Lan, Peck, Richard, Allerheiligen, Sandra R. B.

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Confidence interval criteria for assessment of dose proportionality by SMITH, Brian P, VANDENHENDE, Francois R, DESANTE, Karl A, FARID, Nagy A, WELCH, Pamela A, CALLAGHAN, John T, FORGUE, S. Thomas

“…The aim of this work was a pragmatic, statistically sound and clinically relevant approach to dose-proportionality analyses that is compatible with common…”
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CHARACTERIZATION OF A 7 DAY 17β-ESTRADIOL TRANSDERMAL DELIVERY SYSTEM: PHARMACOKINETICS IN HEALTHY POSTMENOPAUSAL WOMEN by Boyd, Rebecca A., Zegarac, Elizabeth A., Eldon, Michael A., Sedman, Allen J., Thomas Forgue, S.

“…To assess the delivery characteristics of a new 7 day 17β‐estradiol transdermal delivery system (TDS), estradiol and estrone pharmacokinetics were evaluated…”
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Inhibition of tacrine oral clearance by cimetidine by Forgue, S T, Reece, P A, Sedman, A J, deVries, T M

“…Plasma tacrine, 1-hydroxytacrine, 2-hydroxytacrine, and 4-hydroxytacrine concentrations were measured in 12 healthy elderly subjects in this nonblinded…”
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Effects of atorvastatin, an HMG-CoA reductase inhibitor, on hepatic oxidative metabolism of antipyrine by Yang, B B, Hounslow, N J, Sedman, A J, Forgue, S T

“…Possible effects of multiple-dose administration of atorvastatin on the pharmacokinetics of single-dose antipyrine were evaluated in this drug-drug interaction…”
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Pharmacokinetic and pharmacodynamic comparisons of twice daily and four times daily formulations of procainamide in patients with frequent ventricular premature depolarization by Yang, B B, Abel, R B, Uprichard, A C, Smithers, J A, Forgue, S T

“…A study was conducted to evaluate the pharmacokinetics of procainamide and its active metabolite, N-acetylprocainamide (NAPA), as a function of dose and…”
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Pharmacokinetics of a 7-day 17 beta-estradiol transdermal delivery system: effect of application site and repeated applications on serum concentrations of estradiol and estrone by Boyd, R A, Yang, B B, Abel, R B, Eldon, M A, Sedman, A J, Forgue, S T

“…FemPatch (Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI), a new 7-day 17 beta-estradiol transdermal delivery system…”
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Rat brain tubulin: subunit heterogeneity and phosphorylation by Forgue, S T, Dahl, J L

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Direct evidence that an arene oxide is a metabolic intermediate of 2,2',5,5'-tetrachlorobiphenyl by Forgue, S T, Preston, B D, Hargraves, W A, Reich, I L, Allen, J R

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Determination of tiodazosin concentrations in human plasma with a fluorescence high-performance liquid chromatographic method by Forgue, S T, Van Harken, D R, Smyth, R D

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High-performance liquid chromatographic analysis of a novel carbapenem antibiotic in human plasma and urine by Forgue, S T, Pittman, K A, Barbhaiya, R H

“…High-performance liquid chromatographic methods for quantification of a novel carbapenem anti-infective agent, I, in plasma and urine have been developed,…”
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