Search Results - "Forest, M"

Antibody protection from SARS-CoV-2 respiratory tract exposure and infection by Chen, Alex, Wessler, Timothy, Gregory Forest, M.

“…•We model antibody responses to SARS-CoV-2 with a stochastic agent-based framework.•Muco-trapping antibodies crosslink infectious virions to mucin…”
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Benchmarking the immersed boundary method for viscoelastic flows by Gruninger, Cole, Barrett, Aaron, Fang, Fuhui, Gregory Forest, M., Griffith, Boyce E.

“…We present and analyze a series of benchmark tests regarding the application of the immersed boundary (IB) method to viscoelastic flows through and around…”
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Pathological mucus and impaired mucus clearance in cystic fibrosis patients result from increased concentration, not altered pH by Hill, David B, Long, Robert F, Kissner, William J, Atieh, Eyad, Garbarine, Ian C, Markovetz, Matthew R, Fontana, Nicholas C, Christy, Matthew, Habibpour, Mehdi, Tarran, Robert, Forest, M Gregory, Boucher, Richard C, Button, Brian

“…Cystic fibrosis (CF) is a recessive genetic disease that is characterised by airway mucus plugging and reduced mucus clearance. There are currently alternative…”
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Revealing disease-associated pathways by network integration of untargeted metabolomics by Pirhaji, Leila, Milani, Pamela, Leidl, Mathias, Curran, Timothy, Avila-Pacheco, Julian, Clish, Clary B, White, Forest M, Saghatelian, Alan, Fraenkel, Ernest

“…A network-based method and computational tool, PIUMet, reveals disease-associated molecular pathways from untargeted metabolomics data without requiring…”
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Transient crosslinking kinetics optimize gene cluster interactions by Walker, Benjamin, Taylor, Dane, Lawrimore, Josh, Hult, Caitlin, Adalsteinsson, David, Bloom, Kerry, Forest, M Gregory

“…Our understanding of how chromosomes structurally organize and dynamically interact has been revolutionized through the lens of long-chain polymer physics…”
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A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease by Hill, David B, Vasquez, Paula A, Mellnik, John, McKinley, Scott A, Vose, Aaron, Mu, Frank, Henderson, Ashley G, Donaldson, Scott H, Alexis, Neil E, Boucher, Richard C, Forest, M Gregory

“…In human airways diseases, including cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD), host defense is compromised and airways…”
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Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition by Stopfer, Lauren E., Mesfin, Joshua M., Joughin, Brian A., Lauffenburger, Douglas A., White, Forest M.

“…Peptides bound to class I major histocompatibility complexes (MHC) play a critical role in immune cell recognition and can trigger an antitumor immune response…”
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Convolutional neural networks automate detection for tracking of submicron-scale particles in 2D and 3D by Newby, Jay M., Schaefer, Alison M., Lee, Phoebe T., Forest, M. Gregory, Lai, Samuel K.

“…Particle tracking is a powerful biophysical tool that requires conversion of large video files into position time series, i.e., traces of the species of…”
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Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis by Esther, Jr, Charles R, Muhlebach, Marianne S, Ehre, Camille, Hill, David B, Wolfgang, Matthew C, Kesimer, Mehmet, Ramsey, Kathryn A, Markovetz, Matthew R, Garbarine, Ian C, Forest, M Gregory, Seim, Ian, Zorn, Bryan, Morrison, Cameron B, Delion, Martial F, Thelin, William R, Villalon, Diane, Sabater, Juan R, Turkovic, Lidija, Ranganathan, Sarath, Stick, Stephen M, Boucher, Richard C

“…Although destructive airway disease is evident in young children with cystic fibrosis (CF), little is known about the nature of the early CF lung environment…”
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High-Density, Targeted Monitoring of Tyrosine Phosphorylation Reveals Activated Signaling Networks in Human Tumors by Stopfer, Lauren E, Flower, Cameron T, Gajadhar, Aaron S, Patel, Bhavin, Gallien, Sebastien, Lopez-Ferrer, Daniel, White, Forest M

“…Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly dysregulated in cancer. As a result, profiling tumor pTyr levels…”
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Antigen discovery for the development of cancer immunotherapy by Ahn, Ryuhjin, Cui, Yufei, White, Forest M.

“…Central to successful cancer immunotherapy is effective T cell antitumor immunity. Multiple targeted immunotherapies engineered to invigorate T cell-driven…”
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Peak learning of mass spectrometry imaging data using artificial neural networks by Abdelmoula, Walid M., Lopez, Begona Gimenez-Cassina, Randall, Elizabeth C., Kapur, Tina, Sarkaria, Jann N., White, Forest M., Agar, Jeffrey N., Wells, William M., Agar, Nathalie Y. R.

“…Mass spectrometry imaging (MSI) is an emerging technology that holds potential for improving, biomarker discovery, metabolomics research, pharmaceutical…”
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The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors by Miao, Lei, Newby, Jay M, Lin, C. Michael, Zhang, Lu, Xu, Feifei, Kim, William Y, Forest, M. Gregory, Lai, Samuel K, Milowsky, Matthew I, Wobker, Sara E, Huang, Leaf

“…The binding site barrier (BSB) was originally proposed to describe the binding behavior of antibodies to cells peripheral to blood vessels, preventing their…”
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Multiple Reaction Monitoring for Robust Quantitative Proteomic Analysis of Cellular Signaling Networks by Wolf-Yadlin, Alejandro, Hautaniemi, Sampsa, Lauffenburger, Douglas A., White, Forest M.

“…Although recent developments in MS have enabled the identification and quantification of hundreds of phosphorylation sites from a given biological sample,…”
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Oncogenic EGFR signaling networks in glioma by Huang, Paul H, Xu, Alexander M, White, Forest M

“…The epidermal growth factor receptor (EGFR) is a primary contributor to glioblastoma (GBM) initiation and progression. Here, we examine how EGFR and key…”
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Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I by Leddy, Owen, White, Forest M, Bryson, Bryan D

“…CD8+ T cell recognition of ( )-specific peptides presented on major histocompatibility complex class I (MHC-I) contributes to immunity to tuberculosis (TB),…”
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Rheological Tuning of Entangled Polymer Networks by Transient Cross-links by Cao, Xue-Zheng, Forest, M. Gregory

“…The remarkable functionalities of transiently cross-linked, biopolymer networks are increasingly becoming translated into synthetic materials for biomedical…”
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Modeling the Excess Cell Surface Stored in a Complex Morphology of Bleb-Like Protrusions by Kapustina, Maryna, Tsygankov, Denis, Zhao, Jia, Wessler, Timothy, Yang, Xiaofeng, Chen, Alex, Roach, Nathan, Elston, Timothy C, Wang, Qi, Jacobson, Ken, Forest, M Gregory

“…Cells transition from spread to rounded morphologies in diverse physiological contexts including mitosis and mesenchymal-to-amoeboid transitions. When these…”
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Hydrodynamic Theories for Flows of Active Liquid Crystals and the Generalized Onsager Principle by Yang, Xiaogang, Li, Jun, est, M Gregory, Wang, Qi

“…We articulate and apply the generalized Onsager principle to derive transport equations for active liquid crystals in a fixed domain as well as in a free…”
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Centromere Tethering Confines Chromosome Domains by Verdaasdonk, Jolien Suzanne, Vasquez, Paula Andrea, Barry, Raymond Mario, Barry, Timothy, Goodwin, Scott, Forest, M. Gregory, Bloom, Kerry

“…The organization of chromosomes into territories plays an important role in a wide range of cellular processes, including gene expression, transcription, and…”
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