Search Results - "Fordyce, M"

Comprehensive, high-resolution binding energy landscapes reveal context dependencies of transcription factor binding by Le, Daniel D., Shimko, Tyler C., Aditham, Arjun K., Keys, Allison M., Longwell, Scott A., Orenstein, Yaron, Fordyce, Polly M.

“…Transcription factors (TFs) are primary regulators of gene expression in cells, where they bind specific genomic target sites to control transcription…”
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Double Emulsion Picoreactors for High-Throughput Single-Cell Encapsulation and Phenotyping via FACS by Brower, Kara K, Khariton, Margarita, Suzuki, Peter H, Still, Chris, Kim, Gaeun, Calhoun, Suzanne G. K, Qi, Lei S, Wang, Bo, Fordyce, Polly M

“…In the past five years, droplet microfluidic techniques have unlocked new opportunities for the high-throughput genome-wide analysis of single cells,…”
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Design automation of microfluidic single and double emulsion droplets with machine learning by Lashkaripour, Ali, McIntyre, David P., Calhoun, Suzanne G. K., Krauth, Karl, Densmore, Douglas M., Fordyce, Polly M.

“…Droplet microfluidics enables kHz screening of picoliter samples at a fraction of the cost of other high-throughput approaches. However, generating stable…”
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On the dependent recognition of some long zinc finger proteins by Zuo, Zheng, Billings, Timothy, Walker, Michael, Petkov, Petko M, Fordyce, Polly M, Stormo, Gary D

“…Abstract The human genome contains about 800 C2H2 zinc finger proteins (ZFPs), and most of them are composed of long arrays of zinc fingers. Standard ZFP…”
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Phosphatase specificity principles uncovered by MRBLE:Dephos and global substrate identification by Hein, Jamin B, Nguyen, Hieu T, Garvanska, Dimitriya H, Nasa, Isha, Kruse, Thomas, Feng, Yinnian, Lopez Mendez, Blanca, Davey, Norman, Kettenbach, Arminja N, Fordyce, Polly M, Nilsson, Jakob

“…Phosphoprotein phosphatases (PPPs) regulate major signaling pathways, but the determinants of phosphatase specificity are poorly understood. This is because…”
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Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro by Block, Steven M, Valentine, Megan T, Fordyce, Polly M, Krzysiak, Troy C, Gilbert, Susan P

“…Eg5, a member of the kinesin superfamily of microtubule-based motors, is essential for bipolar spindle assembly and maintenance during mitosis, yet little is…”
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Diversification of DNA binding specificities enabled SREBP transcription regulators to expand the repertoire of cellular functions that they govern in fungi by Del Olmo Toledo, Valentina, Puccinelli, Robert, Fordyce, Polly M, Pérez, J Christian

“…The Sterol Regulatory Element Binding Proteins (SREBPs) are basic-helix-loop-helix transcription regulators that control the expression of sterol biosynthesis…”
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Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains by Lohse, Matthew B., Hernday, Aaron D., Fordyce, Polly M., Noiman, Liron, Sorrells, Trevor R., Hanson-Smith, Victor, Nobile, Clarissa J., DeRisi, Joseph L., Johnson, Alexander D.

“…Sequence-specific DNA-binding proteins are among the most important classes of gene regulatory proteins, controlling changes in transcription that underlie…”
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How duplicated transcription regulators can diversify to govern the expression of nonoverlapping sets of genes by Pérez, J Christian, Fordyce, Polly M, Lohse, Matthew B, Hanson-Smith, Victor, DeRisi, Joseph L, Johnson, Alexander D

“…The duplication of transcription regulators can elicit major regulatory network rearrangements over evolutionary timescales. However, few examples of…”
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A lead isotopic study of the human bioaccessibility of lead in urban soils from Glasgow, Scotland by Farmer, John G., Broadway, Andrew, Cave, Mark R., Wragg, Joanna, Fordyce, Fiona M., Graham, Margaret C., Ngwenya, Bryne T., Bewley, Richard J.F.

“…The human bioaccessibility of lead (Pb) in Pb-contaminated soils from the Glasgow area was determined by the Unified Bioaccessibility Research Group of Europe…”
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Systematic characterization of feature dimensions and closing pressures for microfluidic valves produced via photoresist reflow by Fordyce, P M, Diaz-Botia, C A, DeRisi, J L, Gomez-Sjoberg, R

“…Multilayer soft lithography (MSL) provides a convenient and low-cost method for fabricating poly(dimethyl siloxane) (PDMS) microfluidic devices with on-chip…”
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Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses by Fordyce, Polly M, Pincus, David, Kimmig, Philipp, Nelson, Christopher S, El-Samad, Hana, Walter, Peter, DeRisi, Joseph L

“…A quantitative understanding of how transcription factors interact with genomic target sites is crucial for reconstructing transcriptional networks in vivo…”
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Simultaneous, coincident optical trapping and single-molecule fluorescence by Block, Steven M, Lang, Matthew J, Fordyce, Polly M, Engh, Anita M, Neuman, Keir C

“…We constructed a microscope-based instrument capable of simultaneous, spatially coincident optical trapping and single-molecule fluorescence. The capabilities…”
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MRBLE-pep Measurements Reveal Accurate Binding Affinities for B56, a PP2A Regulatory Subunit by Hein, Jamin B, Cyert, Martha S, Fordyce, Polly M

“…Signal transduction pathways rely on dynamic interactions between protein globular domains and short linear motifs (SLiMs). The weak affinities of these…”
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Generation of Paramoeba perurans clonal cultures using flow cytometry and confirmation of virulence by Collins, C, Hall, M, Bruno, D, Sokolowska, J, Duncan, L, Yuecel, R, McCarthy, U, Fordyce, M J, Pert, C C, McIntosh, R, MacKay, Z

“…Amoebic gill disease (AGD) in farmed Atlantic salmon is caused by the amoeba Paramoeba perurans. The recent establishment of in vitro culture techniques for…”
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An open-source, programmable pneumatic setup for operation and automated control of single- and multi-layer microfluidic devices by Brower, Kara, Puccinelli, Robert R., Markin, Craig J., Shimko, Tyler C., Longwell, Scott A., Cruz, Bianca, Gomez-Sjoberg, Rafael, Fordyce, Polly M.

“…[Display omitted] Microfluidic technologies have been used across diverse disciplines (e.g. high-throughput biological measurement, fluid physics, laboratory…”
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Controlled Enantioselective Orientation of Chiral Molecules with an Optical Centrifuge by Milner, Alexander A, Fordyce, Jordan A M, MacPhail-Bartley, Ian, Wasserman, Walter, Milner, Valery, Tutunnikov, Ilia, Averbukh, Ilya Sh

“…We report on the first experimental demonstration of enantioselective rotational control of chiral molecules with a laser field. In our experiments, two…”
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uPIC–M: Efficient and Scalable Preparation of Clonal Single Mutant Libraries for High-Throughput Protein Biochemistry by Appel, Mason J, Longwell, Scott A, Morri, Maurizio, Neff, Norma, Herschlag, Daniel, Fordyce, Polly M

“…New high-throughput biochemistry techniques complement selection-based approaches and provide quantitative kinetic and thermodynamic data for thousands of…”
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initial assessment of spatial relationships between respiratory cases, soil metal content, air quality and deprivation indicators in Glasgow, Scotland, UK: relevance to the environmental justice agenda by Morrison, S, Fordyce, F. M, Scott, E. Marian

“…There is growing interest in links between poor health and socio-environmental inequalities (e.g. inferior housing, crime and industrial emissions) under the…”
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Electrostatic Layer-by-Layer Assembly of CdSe Nanorod/Polymer Nanocomposite Thin Films by McClure, Sean A, Worfolk, Brian J, Rider, David A, Tucker, Ryan T, Fordyce, Jordan A. M, Fleischauer, Michael D, Harris, Ken D, Brett, Michael J, Buriak, Jillian M

“…Electrostatic layer-by-layer assembly was the basis for the synthesis of multilayer nanorod/polymer composite films. Cationic and water-soluble CdSe nanorods…”
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