Search Results - "Forder, J. R."

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors by Dunbar, E. M., Coats, B. S., Shroads, A. L., Langaee, T., Lew, A., Forder, J. R., Shuster, J. J., Wagner, D. A., Stacpoole, P. W.

“…Summary Background Recurrent malignant brain tumors (RMBTs) carry a poor prognosis. Dichloroacetate (DCA) activates mitochondrial oxidative metabolism and has…”
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Relationship between cardiac function and substrate oxidation in hearts of diabetic rats by Chatham, J C, Forder, J R

“…The effects of streptozotocin-induced diabetes on myocardial substrate oxidation and contractile function were investigated using 13C nuclear magnetic…”
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Metabolic compartmentation of lactate in the glucose-perfused rat heart by Chatham, J C, Forder, J R

“…Several studies using exogenous pyruvate as substrate have suggested that there are separate intracellular pyruvate pools in cardiac cells. Such heterogeneity…”
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Quantitative cardiac perfusion: a noninvasive spin-labeling method that exploits coronary vessel geometry by Reeder, S B, Atalay, M K, McVeigh, E R, Zerhouni, E A, Forder, J R

“…To quantitate myocardial arterial perfusion with a noninvasive magnetic resonance (MR) imaging technique that exploits the geometry of coronary vessel anatomy…”
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Oxygenation in the rabbit myocardium: assessment with susceptibility-dependent MR imaging by Atalay, M K, Forder, J R, Chacko, V P, Kawamoto, S, Zerhouni, E A

“…To determine the feasibility of using hemoglobin (Hb) desaturation as an indicator of myocardial oxygenation. High-resolution gradient-echo nuclear magnetic…”
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A novel intrinsic unscented Kalman filter for tractography from HARDI by Cheng, G., Salehian, H., Hwang, M. S., Howland, D., Forder, J. R., Vemuri, B. C.

“…The unscented Kalman filter (UKF) was recently introduced in literature for simultaneous multi-tensor estimation and tractography. This UKF however was not…”
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Quantitative proton spectroscopy of canine brain: in vivo and in vitro correlations by Barker, P B, Breiter, S N, Soher, B J, Chatham, J C, Forder, J R, Samphilipo, M A, Magee, C A, Anderson, J H

“…Quantitative, single-voxel proton NMR spectroscopy of normal brain was performed in five adult beagle dogs using the cerebral water signal as an internal…”
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Preferential inhibition of lactate oxidation relative to glucose oxidation in the rat heart following diabetes by CHATHAM, J. C, GAO, Z.-P, BONEN, A, FORDER, J. R

“…Alterations in myocardial metabolism occur early after the onset of diabetes suggesting that they may play a role in the development of cardiac dysfunction…”
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Blood oxygenation dependence of T1 and T2 in the isolated, perfused rabbit heart at 4.7T by Atalay, M K, Reeder, S B, Zerhouni, E A, Forder, J R

“…An MR line scan protocol has been used to measure relaxation parameters (T1 and T2) in isolated, blood perfused rabbit hearts at various blood oxygenations…”
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Simultaneous noninvasive determination of regional myocardial perfusion and oxygen content in rabbits: toward direct measurement of myocardial oxygen consumption at MR imaging by Reeder, S B, Holmes, A A, McVeigh, E R, Forder, J R

“…To determine whether myocardial arterial perfusion and oxygen concentration can be quantified simultaneously from the same images by using spin labeling and…”
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Hemodynamic effects of intraatrial administration of deferoxamine or deferoxamine-pentafraction conjugate to conscious dogs by Forder, J R, McClanahan, T B, Gallagher, K P, Hedlund, B E, Hallaway, P E, Shlafer, M

“…Deferoxamine (DFX) is a specific Fe3+ chelator that is used to manage iron overload, and is being evaluated as an agent to reduce ischemic organ damage that…”
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Drug-induced impairment of pulmonary [3H]prostaglandin E1 removal in vivo by Pitt, B R, Forder, J R, Gillis, C N

“…Pulmonary removal of [3H]prostaglandin (PG)E1 was measured from multiple indicator dilution techniques using [14C]dextran as an intravascular marker in…”
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Acute L-triiodothyronine administration potentiates inotropic responses to β-adrenergic stimulation in the isolated perfused rat heart by Tielens, Emile T., Forder, J.R., Chatham, J.C., Marrelli, S.P., Ladenson, P.W.

“…Objective: Acute inotropic effects of triiodothyronine (T3) have been reported, employing both in vivo experimental animal models and in vitro isolated heart…”
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A versatile oxygenator and perfusion system for magnetic resonance studies by GAMCSIK, M. P, FORDER, J. R, MILLIS, K. K, MCGOVERN, K. A

“…A compact, reusable membrane oxygenator has been constructed for the perfusion of cultured cells and isolated organs. While the oxygenator was designed to be…”
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Cerium chloride as a histochemical marker of hydrogen peroxide in reperfused ischemic hearts by Shlafer, M, Brosamer, K, Forder, J R, Simon, R H, Ward, P A, Grum, C M

“…Hydrogen peroxide (H2O2) has been implicated in cardiac damage due to ischemia and reperfusion. We adapted an electron microscopic, histochemical method for…”
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Evidence of separate pathways for lactate uptake and release by the perfused rat heart by Chatham, J C, Des Rosiers, C, Forder, J R

“…The simultaneous release and uptake of lactate by the heart has been observed both in vivo and ex vivo; however, the pathways underlying these observations…”
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Feasibility of 19F imaging of perfluorochemical emulsions to measure myocardial vascular volume by Judd, R M, Rottman, G A, Forder, J R, Yin, F C, Blackband, S J

“…19F magnetic resonance images were obtained of the ventricular walls of isolated rabbit hearts perfused with a perfluorochemical (PFC) emulsion. Since the PFC…”
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Two-component diffusion tensor MRI of isolated perfused hearts by Hsu, Edward W., Buckley, David L., Bui, Jonathan D., Blackband, Stephen J., Forder, John R.

“…Nonmonoexponential MR diffusion decay behavior has been observed at high diffusion‐weighting strengths for cell aggregates and tissues, including the…”
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Atlas construction from high angular resolution diffusion imaging data represented by Gaussian Mixture fields by Guang Cheng, Vemuri, B C, Min-Sig Hwang, Howland, D, Forder, J R

“…Groupwise image registration is an essential part of atlas construction which is a very import and challenging task in medical image analysis. In this paper,…”
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Lactic acid and protein interactions: implications for the NMR visibility of lactate in biological systems by Chatham, John C., Forder, John R.

“…The addition of bovine serum albumin (BSA) to a solution of lactate and alanine resulted in the disappearance of the 1H-NMR resonances from lactate but not…”
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