Search Results - "Ford, S.P"

Maternal obesity up-regulates inflammatory signaling pathways and enhances cytokine expression in the mid-gestation sheep placenta by Zhu, M.J, Du, M, Nathanielsz, P.W, Ford, S.P

“…Abstract Obesity in pregnant women is a growing public health concern. The placenta is a source of cytokines which can induce maternal gestational insulin…”
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Upregulation of growth signaling and nutrient transporters in cotyledons of early to mid-gestational nutrient restricted ewes by Ma, Y, Zhu, M.J, Uthlaut, A.B, Nijland, M.J, Nathanielsz, P.W, Hess, B.W, Ford, S.P

“…Abstract Multiparous ewes received 100% (control, C, n  = 13) or 50% (nutrient restricted, NR, n  = 14) of NRC dietary requirements from d28-d78 of gestation…”
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Maternal obesity in ewes results in reduced fetal pancreatic β-cell numbers in late gestation and decreased circulating insulin concentration at term by Zhang, L., Long, N.M., Hein, S.M., Ma, Y., Nathanielsz, P.W., Ford, S.P.

“…About 30% of U.S. women of reproductive age are obese, a condition linked to offspring obesity and diabetes. This study utilized an ovine model of maternal…”
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Down-Regulation of Growth Signaling Pathways Linked to a Reduced Cotyledonary Vascularity in Placentomes of Over-Nourished, Obese Pregnant Ewes by Zhu, M.J, Du, M, Nijland, M.J, Nathanielsz, P.W, Hess, B.W, Moss, G.E, Ford, S.P

“…Abstract Both protein kinase B (Akt) and extracellular signal-regulated kinase 1/2 (ERK1/2) are down-stream components of the insulin/insulin like growth…”
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Periconceptional Nutrient Restriction in the Ewe Alters MAPK/ERK1/2 and PI3K/Akt Growth Signaling Pathways and Vascularity in the Placentome by Zhu, M.J, Du, M, Hess, B.W, Nathanielsz, P.W, Ford, S.P

“…Abstract This study evaluated the role of MAPK/ERK1/2 and/or PI3K/Akt signaling pathways in modulating ovine placentomal vascularity in response to…”
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Pre-slaughter transport, AMP-activated protein kinase, glycolysis, and quality of pork loin by Shen, Q.W., Means, W.J., Thompson, S.A., Underwood, K.R., Zhu, M.J., McCormick, R.J., Ford, S.P., Du, M.

“…Numerous studies have revealed that pre-slaughter stress, like transport, increases the occurrence of pale, soft, and exudative (PSE) pork meat. The molecular…”
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Maternal Nutrient Restriction Upregulates Growth Signaling Pathways in the Cotyledonary Artery of Cow Placentomes by Zhu, M.J, Du, M, Hess, B.W, Means, W.J, Nathanielsz, P.W, Ford, S.P

“…Abstract This study evaluated the role of MAPK/ERK1/2 and/or PI3-K/Akt signaling pathways in modulating bovine placentomal vascularity in response to maternal…”
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The impact of maternal overnutrition and obesity on hypothalamic-pituitary-adrenal axis response of offspring to stress by Long, N.M., Nathanielsz, P.W., Ford, S.P.

“…We evaluated the effect of maternal obesity before and throughout gestation on offspring hypothalamic-pituitary-adrenal axis function. Multiparous Rambouillet…”
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AMP-activated protein kinase is negatively associated with intramuscular fat content in longissimus dorsi muscle of beef cattle by Underwood, K.R., Means, W.J., Zhu, M.J., Ford, S.P., Hess, B.W., Du, M.

“…Marbling, or intramuscular fat, is an important factor in meat quality. As a key regulator of lipid metabolism, AMP activated protein kinase (AMPK) may be…”
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Hypothalamic expression of genes for appetite regulators and estrogen α, estrogen β and leptin receptors in obese dams and their fetuses by Breton, A. B., Cockrum, R. R., Austin, K. J., Cammack, K. M., Ford, S. P., Hess, B. W., Moss, G. E., Nathanielsz, P. W., Alexander, B. M.

“…Under- and over-nutrition during gestation may influence fetal hypothalamic development resulting in individuals predisposed to adverse health effects. This…”
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5E-4 Maternal obesity and high energy diet accelerates fetal pancreatic beta cell development by Nathanielsz, P.W, Zhu, M, Zhang, L, Miller, M.M, Hess, B.W, Nijland, M.J, Moss, G.E, Ford, S.P

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3E-4 Maternal obesity and high energy diet accelerates fetal pancreatic beta cell development by Nathanielsz, P.W, Zhu, M, Zhang, L, Miller, M.M, Hess, B.W, Nijland, M.J, Moss, G.E, Ford, S.P

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Fetal programming of skeletal muscle development in ruminant animals by Du, M, Tong, J, Zhao, J, Underwood, K.R, Zhu, M, Ford, S.P, Nathanielsz, P.W

“…Enhancing skeletal muscle growth is crucial for animal agriculture because skeletal muscle provides meat for human consumption. An increasing body of evidence…”
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Increased milk production versus reproductive and energy status of high producing dairy cows by Harrison, R O, Ford, S P, Young, J W, Conley, A J, Freeman, A E

“…Two groups of 10 Holstein cows were chosen by pairs from a 20-yr genetic selection project that used either breed average or breed high sires chosen only for…”
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Multigenerational impact of maternal overnutrition/obesity in the sheep on the neonatal leptin surge in granddaughters by Shasa, D R, Odhiambo, J F, Long, N M, Tuersunjiang, N, Nathanielsz, P W, Ford, S P

“…Background/objectives: We have reported that maternal overnutrition/obesity (OB) in sheep resulting from feeding 150% of National Research Council (NRC)…”
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Effects of maternal obesity in an ovine model on metabolic outcomes in F2 adults and F3 neonates by Pankey, C.L., Odhiambo, J.F., Smith, A.M., Ford, S.P.

“…•Maternal obesity programs diminishing metabolic phenotypes over 3 generations.•Gestation exposes latent phenotypes in second generation offspring of obese…”
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Maternal obesity and increased nutrient intake before and during gestation in the ewe results in altered growth, adiposity, and glucose tolerance in adult offspring by Long, N.M, George, L.A, Uthlaut, A.B, Smith, D.T, Nijland, M.J, Nathanielsz, P.W, Ford, S.P

“…We evaluated the effects of preconception and gestational obesity in the ewe on offspring growth, metabolism, and glucose homeostasis. From 60 d before…”
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Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development by Yan, X, Huang, Y, Zhao, J-X, Rogers, C J, Zhu, M-J, Ford, S P, Nathanielsz, P W, Du, M

“…Background: Obesity in women of childbearing age is increasing at an alarming rate. Growing evidence shows that maternal obesity induces detrimental effects on…”
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Effects of maternal obesity on maternal and fetal plasma concentrations of adiponectin and expression of adiponectin and its receptor genes in cotyledonary and adipose tissues at mid- and late-gestation in sheep by Fensterseifer, S.R., Austin, K.J., Ford, S.P., Alexander, B.M.

“…Adiponectin potentially influences fetal weight by altering insulin signaling and trans-placental amino acid and glucose transporters. The objective of this…”
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Intergenerational impact of maternal overnutrition and obesity throughout pregnancy in sheep on metabolic syndrome in grandsons and granddaughters by Pankey, C.L., Walton, M.W., Odhiambo, J.F., Smith, A.M., Ghnenis, A.B., Nathanielsz, P.W., Ford, S.P.

“…We previously reported that maternal overnutrition and obesity (MO) throughout pregnancy and lactation in sheep (MOF0) decreases term fetal pancreatic β-cell…”
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