Search Results - "Ford, Mandy L."

T Cell Cosignaling Molecules in Transplantation by Ford, Mandy L.

“…The ultimate outcome of alloreactivity versus tolerance following transplantation is potently influenced by the constellation of cosignaling molecules…”
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Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes by Estrada, Jose L., Martens, Greg, Li, Ping, Adams, Andrew, Newell, Kenneth A., Ford, Mandy L., Butler, James R., Sidner, Richard, Tector, Matt, Tector, Joseph

“…Background Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4GalNT2…”
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Mechanisms of Intestinal Barrier Dysfunction in Sepsis by Yoseph, Benyam P, Klingensmith, Nathan J, Liang, Zhe, Breed, Elise R, Burd, Eileen M, Mittal, Rohit, Dominguez, Jessica A, Petrie, Benjamin, Ford, Mandy L, Coopersmith, Craig M

“…ABSTRACTIntestinal barrier dysfunction is thought to contribute to the development of multiple organ dysfunction syndrome in sepsis. Although there are…”
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Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway by Adams, Andrew B, Ford, Mandy L, Larsen, Christian P

“…T cell activation is a complex process that requires multiple cell signaling pathways, including a primary recognition signal and additional costimulatory…”
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IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis by Morrow, Kristen N, Coopersmith, Craig M, Ford, Mandy L

“…Sepsis is a major cause of morbidity and mortality worldwide despite numerous attempts to identify effective therapeutics. While some sepsis deaths are…”
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Cancer and sepsis by Williams, Jeroson C, Ford, Mandy L, Coopersmith, Craig M

“…Sepsis is one of the leading causes of death worldwide. While mortality is high regardless of inciting infection or comorbidities, mortality in patients with…”
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Targeting co-stimulatory pathways: transplantation and autoimmunity by Ford, Mandy L., Adams, Andrew B., Pearson, Thomas C.

“…Key Points T-cell co-stimulatory signals, expressed either constitutively or upon activation, critically affect the magnitude and character of autoreactive or…”
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Balancing Inflammation: The Link between Th17 and Regulatory T Cells by Lawson, David H., Delman, Keith A., Kudchadkar, Ragini R., Diller, Maggie L., Ford, Mandy L.

“…CD4+ T cell compartments in mouse and man are composed of multiple distinct subsets each possessing unique phenotypic and functional characteristics…”
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CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcγRIIB by Bennion, Kelsey B., Liu, Danya, Dawood, Abdelhameed S., Wyatt, Megan M., Alexander, Katie L., Abdel-Hakeem, Mohamed S., Paulos, Chrystal M., Ford, Mandy L.

“…The regulatory circuits dictating CD8 + T cell responsiveness versus exhaustion during anti-tumor immunity are incompletely understood. Here we report that…”
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Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model by Higginbotham, Laura, Mathews, Dave, Breeden, Cynthia A., Song, Mingqing, Farris III, Alton Brad, Larsen, Christian P., Ford, Mandy L., Lutz, Andrew J., Tector, Matthew, Newell, Kenneth A., Tector, A. Joseph, Adams, Andrew B.

“…Xenotransplantation has the potential to alleviate the organ shortage that prevents many patients with end‐stage renal disease from enjoying the benefits of…”
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Selective CD28 blockade impacts T cell differentiation during homeostatic reconstitution following lymphodepletion by Habib, Jakob G, Liu, Danya, Crepeau, Rebecca M, Wagener, Maylene E, Ford, Mandy L

“…Costimulation blockade targeting the CD28 pathway provides improved long-term renal allograft survival compared to calcineurin inhibitors but may be limited as…”
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Impact of chronic alcohol exposure on conventional and regulatory murine T cell subsets by Paterson, Cameron W, Gutierrez, Melissa B, Coopersmith, Craig M, Ford, Mandy L

“…Chronic alcohol use poses significant negative consequences to public health and, among its many biologic effects, is associated with significant T cell…”
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Translating costimulation blockade to the clinic: lessons learned from three pathways by Ford, Mandy L, Larsen, Christian P

“…As the recognition that costimulatory signals are critical for optimal T-cell activation, proliferation, and differentiation, there has been an explosion in…”
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CD8 + T cells are necessary for improved sepsis survival induced by CD28 agonism in immunologically experienced mice by Anyalebechi, Jerome C, Sun, Yini, Davis, Carolyn, Wagener, Maylene E, Liang, Zhe, Burd, Eileen M, Coopersmith, Craig M, Ford, Mandy L

“…A hallmark of T cell dysregulation during sepsis is the downregulation of costimulatory molecules. CD28 is one of T cell costimulatory molecules significantly…”
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Gram‐negative bacteremia in solid organ transplant recipients: Clinical characteristics and outcomes as compared to immunocompetent non‐transplant recipients by Eichenberger, Emily M., Troy, Jesse, Ruffin, Felicia, Dagher, Michael, Thaden, Joshua T., Ford, Mandy L., Fowler, Vance G.

“…Background Outcomes from Gram‐negative bacteremia (GNB) in solid organ transplant (SOT) recipients are poorly understood. Methods This is a single center…”
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Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade by Ferrer, Ivana R, Wagener, Maylene E, Song, Minqing, Kirk, Allan D, Larsen, Christian P, Ford, Mandy L

“…Blockade of the CD40/CD154 pathway potently attenuates T-cell responses in models of autoimmunity, inflammation, and transplantation. Indeed, CD40 pathway…”
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CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis by Ramonell, Kimberly M, Zhang, Wenxiao, Hadley, Annette, Chen, Ching-Wen, Fay, Katherine T, Lyons, John D, Klingensmith, Nathan J, McConnell, Kevin W, Coopersmith, Craig M, Ford, Mandy L

“…Sepsis is a dysregulated systemic response to infection involving many inflammatory pathways and the induction of counter-regulatory anti-inflammatory…”
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Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication by Nganou-Makamdop, Krystelle, Billingsley, James M, Yaffe, Zachary, O'Connor, Gregory, Tharp, Gregory K, Ransier, Amy, Laboune, Farida, Matus-Nicodemos, Rodrigo, Lerner, Andrea, Gharu, Lavina, Robertson, Jennifer M, Ford, Mandy L, Schlapschy, Martin, Kuhn, Nadine, Lensch, Alexandra, Lifson, Jeffrey, Nason, Martha, Skerra, Arne, Schreiber, Gideon, Bosinger, Steven E, Douek, Daniel C

“…Chronic activation of the immune system in HIV infection is one of the strongest predictors of morbidity and mortality. As such, approaches that reduce immune…”
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Influence of T Cell Coinhibitory Molecules on CD8 + Recall Responses by Morris, Anna B, Adams, Layne E, Ford, Mandy L

“…T cell co-signaling molecules play an important role in fine-tuning the strength of T cell activation during many types of immune responses, including…”
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Pre-existing malignancy results in increased prevalence of distinct populations of CD4+ T cells during sepsis by Xie, Jianfeng, Robertson, Jennifer M, Chen, Ching-Wen, Zhang, Wenxiao, Coopersmith, Craig M, Ford, Mandy L

“…The presence of pre-existing malignancy in murine hosts results in increased immune dysregulation and risk of mortality following a septic insult. Based on the…”
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