Search Results - "Ford, ML"

Sepsis erodes CD8+ memory T cell‐protective immunity against an EBV homolog in a 2B4‐dependent manner by Xie, Jianfeng, Crepeau, Rebecca L., Chen, Ching‐wen, Zhang, Wenxiao, Otani, Shunsuke, Coopersmith, Craig M., Ford, Mandy L.

“…Epstein–Barr virus (EBV) reactivation commonly occurs following sepsis, but the mechanisms underlying this are unknown. We utilized a murine EBV homolog (gHV)…”
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Belatacept‐Resistant Rejection Is Associated With CD28+ Memory CD8 T Cells by Mathews, D. V., Wakwe, W. C., Kim, S. C., Lowe, M. C., Breeden, C., Roberts, M. E., Farris, A. B., Strobert, E. A., Jenkins, J. B., Larsen, C. P., Ford, M. L., Townsend, R., Adams, A. B.

“…Recently, newer therapies have been designed to more specifically target rejection in an effort to improve efficacy and limit unwanted toxicity. Belatacept, a…”
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Selective CD28 blockade results in superior inhibition of donor-specific T follicular helper cell and antibody responses relative to CTLA-4-Ig by Badell, IR, La Muraglia, GM, Liu, D, Wagener, ME, Ding, G, Ford, ML

“…Donor-specific antibodies (DSA) are a barrier to improved long-term outcomes following kidney transplantation. Costimulation blockade with CTLA-4-Ig has shown…”
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An Anti‐CD154 Domain Antibody Prolongs Graft Survival and Induces Foxp3+ iTreg in the Absence and Presence of CTLA‐4 Ig by Pinelli, D. F., Wagener, M. E., Liu, D., Yamniuk, A., Tamura, J., Grant, S., Larsen, C. P., Suri, A., Nadler, S. G., Ford, M. L.

“…The use of monoclonal antibodies targeting the CD154 molecule remains one of the most effective means of promoting graft tolerance in animal models, but…”
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Pathogen Stimulation History Impacts Donor‐Specific CD8+ T Cell Susceptibility to Costimulation/Integrin Blockade–Based Therapy by Badell, I. R., Kitchens, W. H., Wagener, M. E., Lukacher, A. E., Larsen, C. P., Ford, M. L.

“…Recent studies have shown that the quantity of donor‐reactive memory T cells is an important factor in determining the relative heterologous immunity barrier…”
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Rapamycin ameliorates the CTLA4‐Ig–mediated defect in CD8+ T cell immunity during gammaherpesvirus infection by Pinelli, D. F., Wakeman, B. S., Wagener, M. E., Speck, S. H., Ford, M. L.

“…Latent viral infections are a major concern among immunosuppressed transplant patients. During clinical trials with belatacept, a CTLA4‐Ig fusion protein,…”
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Specificity, magnitude, and kinetics of MOG‐specific CD8+ T cell responses during experimental autoimmune encephalomyelitis by Ford, Mandy L., Evavold, Brian D.

“…Experimental autoimmune encephalomyelitis (EAE) has traditionally been thought to be almost exclusively mediated by CD4+ effector T cells. Here, we provide…”
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CTLA4Ig Prevents Alloantibody Formation Following Nonhuman Primate Islet Transplantation Using the CD40‐Specific Antibody 3A8 by Badell, I. R., Russell, M. C., Cardona, K., Shaffer, V. O., Turner, A. P., Avila, J. G., Cano, J. A., Leopardi, F. V., Song, M., Strobert, E. A., Ford, M. L., Pearson, T. C., Kirk, A. D., Larsen, C. P.

“…Islet transplantation to treat type 1 diabetes has been limited in part by toxicities of current immunosuppression and recipient humoral sensitization…”
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CCR6+ Memory Th17 Cells Preferentially Express CTLA-4 and Are Resistant to Costimulation Blockade: 2538 by Krummey, S. M., Floyd, T. L., Mehta, A. K., Ford, M. L.

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Evaluation of Human and Nonhuman Primate Antibody Binding to Pig Cells Lacking GGTA1/CMAH/β4GalNT2 Genes by Estrada, J, Martens, G, Li, P, Adams, AB, Newell, KA, Ford, ML, Butler, JR, Sidner, RA, Tector, M, Tector, AJ

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Non-Depleting Anti-CD40-Based Therapy Prolongs Allograft Survival in Nonhuman Primates by Badell, IR, Thompson, PW, Turner, AP, Russell, MC, Avila, JG, Cano, JA, Robertson, JM, Leopardi, FV, Strobert, EA, Iwakoshi, NN, Reimann, KA, Ford, ML, Kirk, AD, Larsen, CP

“…Costimulation blockade of the CD40/CD154 pathway has been effective at preventing allograft rejection in numerous transplantation models. This strategy has…”
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Amelioration of Established Experimental Autoimmune Encephalomyelitis by an MHC Anchor-Substituted Variant of Proteolipid Protein 139-151 by Margot, Carrie D, Ford, Mandy L, Evavold, Brian D

“…Murine experimental autoimmune encephalomyelitis (EAE) is a CD4+ T cell-mediated autoimmune disorder directed against myelin proteins within the CNS. We…”
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Regulation of Polyclonal T Cell Responses by an MHC Anchor-Substituted Variant of Myelin Oligodendrocyte Glycoprotein 35-55 by Ford, Mandy L, Evavold, Brian D

“…Analogs of immunogenic peptides containing substitutions at TCR contact residues (altered peptide ligands (APLs)) have been used to manipulate Ag-specific T…”
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Five Years of Experience with the ConnectOregon Multimodal Funding Program by Baker, Teddie A., Bufalino, Michael E., Ford, Mark L., Kale, Steven R.

“…The Oregon legislature in 2005 authorized $100 million in state lottery bond revenues to be used for investments in aviation, marine, rail, and transit…”
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CD43 Modulates Severity and Onset of Experimental Autoimmune Encephalomyelitis by Ford, Mandy L, Onami, Thandi M, Sperling, Anne I, Ahmed, Rafi, Evavold, Brian D

“…Experimental autoimmune encephalomyelitis (EAE) is a mouse model of multiple sclerosis characterized by infiltration of activated CD4(+) T lymphocytes into…”
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An MHC anchor‐substituted analog of myelin oligodendrocyte glycoprotein 35–55 induces IFN‐γ and autoantibodies in the absence of experimental autoimmune encephalomyelitis and optic neuritis by Ford, Mandy L., Evavold, Brian D.

“…Previous strategies to ameliorate experimental autoimmune encephalitis (EAE) include the treatment of autoreactive T cells with altered peptide ligands, which…”
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Degenerate recognition of T cell epitopes: impact of T cell receptor reserve and stability of peptide:MHC complexes by Ford, Mandy L, Evavold, Brian D

“…The concept of molecular mimicry suggests that microbial pathogens might activate antigen-specific T cells that then cross-react with endogenous antigens and…”
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A New Addition to the Corpus of English Incunabula: Wynkyn de Worde's Proprytees & Medicynes of Hors (c. 1497–98) by FORD, MARGARET LANE

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Neural crest cell lineage segregation in the mouse neural tube by Wilson, Yvette M., Richards, Kay L., Ford-Perriss, Miriam L., Panthier, Jean-Jacques, Murphy, Mark

“…Neural crest (NC) cells arise in the dorsal neural tube (NT) and migrate into the embryo to develop into many different cell types. A major unresolved question…”
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Defining the parameters necessary for T-cell recognition of ligands that vary in potency by Kilgore, Neely E, Ford, Mandy L, Margot, Carrie D, Jones, Daniel S, Reichardt, Peter, Evavold, Brian D

“…Identification of the mechanisms by which a T cell is able to sense ligands of varying strength, such as those that mediate tumor growth, viral evasion, and…”
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