Search Results - "Ford, John W."

Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology by Devalla, Harsha D, Schwach, Verena, Ford, John W, Milnes, James T, El‐Haou, Said, Jackson, Claire, Gkatzis, Konstantinos, Elliott, David A, Chuva de Sousa Lopes, Susana M, Mummery, Christine L, Verkerk, Arie O, Passier, Robert

“…Drugs targeting atrial‐specific ion channels, K v 1.5 or K ir 3.1/3.4, are being developed as new therapeutic strategies for atrial fibrillation. However,…”
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New Drugs Targeting the Cardiac Ultra-Rapid Delayed-Rectifier Current (IKur): Rationale, Pharmacology and Evidence for Potential Therapeutic Value by Ford, John W, Milnes, James T

“…There is a clear unmet medical need for new pharmacologic therapies for the treatment of atrial fibrillation (AF) with improved efficacy and safety. This…”
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Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation by ELIASON, Jonathan L, HANNAWA, Kevin K, STANLEY, James C, THOMPSON, Robert W, UPCHURCH, Gilbert R, AILAWADI, Gorav, SINHA, Indranil, FORD, John W, DEOGRACIAS, Michael P, ROELOFS, Karen J, WOODRUM, Derek T, ENNIS, Terri L, HENKE, Peter K

“…Neutrophils may be an important source of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), two matrix-degrading enzymes thought to be…”
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Decreased collagen and increased matrix metalloproteinase-13 in experimental abdominal aortic aneurysms in males compared with females by Cho, Brenda S., PhD, Roelofs, Karen J., DVM, Ford, John W., BS, Henke, Peter K., MD, Upchurch, Gilbert R., MD

“…Background This study examined differences in sex in collagen regulation during rodent experimental abdominal aortic aneurysm formation. Methods Infrarenal…”
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Gender-Dependent Differential Phosphorylation in the ERK Signaling Pathway is Associated with Increased MMP2 Activity in Rat Aortic Smooth Muscle Cells by Ehrlichman, Lauren K., B.A, Ford, John W., B.A, Roelofs, Karen J., D.V.M, Tedeschi-Filho, Wagner, M.D, Futchko, John S, Ramacciotti, Eduardo, M.D., Ph.D, Eliason, Jonathan L., M.D, Henke, Peter K., M.D, Upchurch, Gilbert R., M.D

“…Background The present experiments were conducted to explore the role of mitogen-activated protein kinase (MAPK) pathways, potential upstream regulators of…”
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A Pilot Assessment of 3 Point-of-Care Strategies for Diagnosis of Perioperative Lung Pathology by Ford, John W, Heiberg, Johan, Brennan, Anthony P, Royse, Colin F, Canty, David J, El-Ansary, Doa, Royse, Alistair G

“…BACKGROUND:Lung ultrasonography is superior to clinical examination and chest X-ray (CXR) in diagnosis of acute respiratory pathology in the emergency and…”
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Novel K+ Channel Targets in Atrial Fibrillation Drug Development—Where Are We? by El-Haou, Said, Ford, John W, Milnes, James T

“…There is a clear unmet medical need for new pharmacologic therapies with improved efficacy and safety for the treatment of atrial fibrillation. Considerable…”
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New pharmacological approaches to atrial fibrillation by Milnes, James T., Madge, David J., Ford, John W.

“…Atrial fibrillation (AF) is the most common cardiac arrhythmia facing physicians, afflicting 13% of men and 11% of women over 85 years of age. Epidemiological…”
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Gender Differences in Rat Aortic Smooth Muscle Cell Matrix Metalloproteinase-9 by Woodrum, Derek T., Ford, John W., Ailawadi, Gorav, Pearce, Charles G., Sinha, Indranil, Eagleton, Matthew J., Henke, Peter K., Stanley, James C., Upchurch, Gilbert R.

“…A predilection exists for men to develop abdominal aortic aneurysms (AAAs), but the reasons for this gender predisposition are not known. Matrix…”
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Differential Effect of 17-ß-Estradiol on Smooth Muscle Cell and Aortic Explant MMP2 by Woodrum, Derek T., M.D, Ford, John W., B.A, Cho, Brenda S., Ph.D, Hannawa, Kevin K., M.D, Stanley, James C., M.D, Henke, Peter K., M.D, Upchurch, Gilbert R., M.D., F.A.C.S

“…Objective The present investigation tested the hypothesis that intrinsic gender-related differences exist in rat aortic smooth muscle cell matrix…”
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Differential Effect of 17-β-Estradiol on Smooth Muscle Cell and Aortic Explant MMP2 by WOODRUM, Derek T, FORD, John W, CHO, Brenda S, HANNAWA, Kevin K, STANLEY, James C, HENKE, Peter K, UPCHURCH, Gilbert R

“…The present investigation tested the hypothesis that intrinsic gender-related differences exist in rat aortic smooth muscle cell matrix metalloproteinase 2…”
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A nonintrinsic regional basis for increased infrarenal aortic MMP-9 expression and activity by Ailawadi, Gorav, Knipp, Brian S., Lu, Guanyi, Roelofs, Karen J., Ford, John W., Hannawa, Kevin K., Bishop, Keith, Thanaporn, Porama, Henke, Peter K., Stanley, James C., Upchurch, Gilbert R.

“…Objective: This investigation was undertaken to determine whether intrinsic or regional factors at different anatomic sites of the aorta affect expression and…”
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Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms by Sinha, Indranil, Hannawa, Kevin K., Eliason, Jonathan L., Ailawadi, Gorav, Deogracias, Michael P., Bethi, Siddharth, Ford, John W., Roelofs, Karen J., Grigoryants, Vladimir, Henke, Peter K., Stanley, James C., Upchurch, Gilbert R.

“…The objective of this study was to determine the significance of membrane type 1 matrix metalloproteinase (MT1-MMP) activation of MMP-2 in experimental…”
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Increased MMP-9 expression and activity by aortic smooth muscle cells after nitric oxide synthase inhibition is associated with increased nuclear factor-κB and activator protein-1 activity by Knipp, Brian S, Ailawadi, Gorav, Ford, John W, Peterson, David A, Eagleton, Matthew J, Roelofs, Karen J, Hannawa, Kevin K, Deogracias, Michael P, Ji, Baoan, Logsdon, Craig, Graziano, Kathleen D, Simeone, Diane M, Thompson, Robert W, Henke, Peter K, Stanley, James C, Upchurch, Gilbert R

“…To determine the mechanism underlying increased expression and activity of matrix metalloproteinase 9 (MMP-9) by rat aortic smooth muscle cells (RA-SMC) after…”
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Regulation of Lysyl Oxidase by Interferon-γ in Rat Aortic Smooth Muscle Cells by Song, Yun Ling, Ford, John W, Gordon, David, Shanley, Charles J

“…ABSTRACTLysyl oxidase is an essential catalyst for the cross-linking of extracellular collagen and elastin. Abnormalities in lysyl oxidase activity may…”
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The nitric oxide donor DETA-NONOate decreases matrix metalloproteinase-9 expression and activity in rat aortic smooth muscle and abdominal aortic explants by Sinha, Indranil, Hannawa, Kevin K, Ailawadi, Gorav, Woodrum, Derek T, Ford, John W, Henke, Peter K, Stanley, James C, Eagleton, Matthew J, Upchurch, Jr, Gilbert R

“…Our objective was to examine the role of an exogenous nitric oxide (NO) donor, DETA-NONOate (DETA), on matrix metalloproteinase (MMP)-9, MMP-2, and tissue…”
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Impaired vasoreactivity despite an increase in plasma nitrite in patients with abdominal aortic aneurysms by Knipp, Brian S., Peterson, David A., Rajagopalan, Sanjay, Kehrer, Christine, Ford, John W., D'Alecy, Louis G., Whitesall, Steven E., Eagleton, Matthew J., Wakefield, Thomas W., Henke, Peter K., Jacobs, Lloyd A., Greenfield, Lazar J., Stanley, James C., Upchurch, Gilbert R.

“…Objective: This investigation was designed to determine whether differences in vasoreactivity occur in patients with abdominal aortic aneurysms (AAAs) as…”
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Potassium channels: gene family, therapeutic relevance, high-throughput screening technologies and drug discovery by Ford, John W, Stevens, Edward B, Treherne, J Mark, Packer, Jeremy, Bushfield, Mark

“…Existing drugs that modulate ion channels represent a key class of pharmaceutical agents across many therapeutic areas and there is considerable further…”
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PKH26 and125I-PKH95: Characterization and Efficacy as Labels forin Vitroandin VivoEndothelial Cell Localization and Tracking by Ford, John W., Welling III, Theodore H., Stanley, James C., Messina, Louis M.

“…PKH26, a fluorescent cell label, and PKH95, a125I-radioactive cell label, are both potentially valuable endothelial cell labels because they bind irreversibly…”
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Denis Dunbar Gibbs by Ford, John W K Ward, John M T

“…During his years as a consultant, he was one of the first to use a combined fibreoptic endoscope and gastric camera, he wrote two books and multiple papers,…”
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