Search Results - "Ford, Heide"

Remembering Hypoxia: Uncovering the Long-Term Effects of Transient Oxygen Deprivation on IFN Signaling and Progression of Breast Cancer by Purdy, Stephen Connor, Ford, Heide L

“…Hypoxia occurs in 90% of solid tumors and is strongly associated with an increased propensity for metastasis. Hypoxia induces tumor progression largely through…”
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Epithelial―Mesenchymal Transition and Tumor Suppression Are Controlled by a Reciprocal Feedback Loop between ZEB1 and Grainyhead-like-2 by CIEPLY, Benjamin, FARRIS, Joshua, DENVIR, James, FORD, Heide L, FRISCH, Steven M

“…Epithelial-mesenchymal transition (EMT) in carcinoma cells enhances malignant progression by promoting invasion and survival. EMT is induced by…”
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Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression by Micalizzi, Douglas S, Farabaugh, Susan M, Ford, Heide L

“…From the earliest stages of embryonic development, cells of epithelial and mesenchymal origin contribute to the structure and function of developing organs…”
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Clonal cooperativity in heterogenous cancers by Zhou, Hengbo, Neelakantan, Deepika, Ford, Heide L.

“…Tumor heterogeneity is a major obstacle to the development of effective therapies and is thus an important focus of cancer research. Genetic and epigenetic…”
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EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells by Neelakantan, Deepika, Zhou, Hengbo, Oliphant, Michael U. J., Zhang, Xiaomei, Simon, Lukas M., Henke, David M., Shaw, Chad A., Wu, Meng-Fen, Hilsenbeck, Susan G., White, Lisa D., Lewis, Michael T., Ford, Heide L.

“…Recent fate-mapping studies concluded that EMT is not required for metastasis of carcinomas. Here we challenge this conclusion by showing that these studies…”
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Molecular Pathways: Targeting the TGF-β Pathway for Cancer Therapy by SMITH, Anna L, ROBIN, Tyler P, FORD, Heide L

“…TGF-β is a ubiquitous cytokine that plays an active role in many cellular processes. Nearly every cell type has the ability to secrete TGF-β, as well as the…”
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VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk by Kong, Deguang, Zhou, Hengbo, Neelakantan, Deepika, Hughes, Connor J., Hsu, Jessica Y., Srinivasan, Ramakrishnan Rajaram, Lewis, Michael T., Ford, Heide L.

“…It is well established that a subset of cells within primary breast cancers can undergo an epithelial-to-mesenchymal transition (EMT), although the role of EMT…”
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In Vitro Phosphatase Assays for the Eya2 Tyrosine Phosphatase by Alderman, Christopher, Krueger, Aaron, Rossi, John, Ford, Heide L, Zhao, Rui

“…Protein tyrosine phosphatases (PTP), such as the Eyes Absent (Eya) family of proteins, play important roles in diverse biological processes. In vitro…”
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Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression by Zhang, Lingdi, Zhou, Hengbo, Li, Xueni, Vartuli, Rebecca L, Rowse, Michael, Xing, Yongna, Rudra, Pratyaydipta, Ghosh, Debashis, Zhao, Rui, Ford, Heide L

“…Eya genes encode a unique family of multifunctional proteins that serve as transcriptional co-activators and as haloacid dehalogenase-family Tyr phosphatases…”
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Breast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticity by Drasin, David J, Robin, Tyler P, Ford, Heide L

“…The epithelial-to-mesenchymal transition (EMT) is a critical developmental process that has recently come to the forefront of cancer biology. In breast…”
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Biochemical characterization of the Eya and PP2A-B55α interaction by Alderman, Christopher, Anderson, Ryan, Zhang, Lingdi, Hughes, Connor J., Li, Xueni, Ebmeier, Chris, Wagley, Marisa E., Ahn, Natalie G., Ford, Heide L., Zhao, Rui

“…The eyes absent (Eya) proteins were first identified as co-activators of the six homeobox family of transcription factors and are critical in embryonic…”
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The Eya phosphatase: Its unique role in cancer by Zhou, Hengbo, Zhang, Lingdi, Vartuli, Rebecca L., Ford, Heide L., Zhao, Rui

“…The Eya proteins were originally identified as essential transcriptional co-activators of the Six family of homeoproteins. Subsequently, the highly conserved…”
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Vascular endothelial growth factor C promotes breast cancer progression via a novel antioxidant mechanism that involves regulation of superoxide dismutase 3 by Wang, Chu-An, Harrell, J Chuck, Iwanaga, Ritsuko, Jedlicka, Paul, Ford, Heide L

“…Triple-negative breast cancers, particularly the claudin-low subtype, are highly aggressive and exhibit increased tumor-initiating cell (TIC) characteristics…”
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All eyes on Eya: A unique transcriptional co-activator and phosphatase in cancer by Hughes, Connor J., Alderman, Christopher, Wolin, Arthur R., Fields, Kaiah M., Zhao, Rui, Ford, Heide L.

“…The Eya family of proteins (consisting of Eyas1–4 in mammals) play vital roles in embryogenesis by regulating processes such as proliferation,…”
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Cellular Plasticity in Breast Cancer Progression and Therapy by Kong, Deguang, Hughes, Connor J, Ford, Heide L

“…With the exception of non-melanoma skin cancer, breast cancer is the most frequently diagnosed malignant disease among women, with the majority of mortality…”
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SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma by Hughes, Connor J., Fields, Kaiah M., Danis, Etienne P., Hsu, Jessica Y., Neelakantan, Deepika, Vincent, Melanie Y., Gustafson, Annika L., Oliphant, Michael J., Sreekanth, Varsha, Zaberezhnyy, Vadym, Costello, James C., Jedlicka, Paul, Ford, Heide L.

“…Ewing sarcoma (ES), which is characterized by the presence of oncogenic fusion proteins such as EWS/FLI1, is an aggressive pediatric malignancy with a high…”
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Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development by Tavares, Andre L P, Cox, Timothy C, Maxson, Robert M, Ford, Heide L, Clouthier, David E

“…Jaw morphogenesis is a complex event mediated by inductive signals that establish and maintain the distinct developmental domains required for formation of…”
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Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma by Hsieh, Joseph, Danis, Etienne P, Owens, Charles R, Parrish, Janet K, Nowling, Nathan L, Wolin, Arthur R, Purdy, Stephen Connor, Rosenbaum, Sheera R, Ivancevic, Atma M, Chuong, Edward B, Ford, Heide L, Jedlicka, Paul

“…Rhabdomyosarcoma (RMS), a malignancy of impaired myogenic differentiation, is the most common soft tissue pediatric cancer. PAX3-FOXO1 oncofusions drive the…”
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Structure-function analyses of the human SIX1–EYA2 complex reveal insights into metastasis and BOR syndrome by Patrick, Aaron N, Cabrera, Joshua H, Smith, Anna L, Chen, Xiaojiang S, Ford, Heide L, Zhao, Rui

“…SIX1–EYA form a bipartite transcription factor, essential for development, whose overexpression is linked to metastasis. The crystal structure of SIX1 bound to…”
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Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways by Iwanaga, Ritsuko, Wang, Chu-An, Micalizzi, Douglas S, Harrell, J Chuck, Jedlicka, Paul, Sartorius, Carol A, Kabos, Peter, Farabaugh, Susan M, Bradford, Andrew P, Ford, Heide L

“…Mammary-specific overexpression of Six1 in mice induces tumors that resemble human breast cancer, some having undergone epithelial to mesenchymal transition…”
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