Search Results - "Ford, A W"

Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2 by Riendeau, D, Percival, M D, Brideau, C, Charleson, S, Dubé, D, Ethier, D, Falgueyret, J P, Friesen, R W, Gordon, R, Greig, G, Guay, J, Mancini, J, Ouellet, M, Wong, E, Xu, L, Boyce, S, Visco, D, Girard, Y, Prasit, P, Zamboni, R, Rodger, I W, Gresser, M, Ford-Hutchinson, A W, Young, R N, Chan, C C

“…We report here the preclinical profile of etoricoxib (MK-0663) [5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl) pyridine], a novel orally active…”
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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor by Riendeau, D, Percival, M D, Boyce, S, Brideau, C, Charleson, S, Cromlish, W, Ethier, D, Evans, J, Falgueyret, J ‐P, Ford‐Hutchinson, A W, Gordon, R, Greig, G, Gresser, M, Guay, J, Kargman, S, Léger, S, Mancini, J A, O'Neill, G, Ouellet, M, Rodger, I W, Thérien, M, Wang, Z, Webb, J K, Wong, E, Xu, L, Young, R N, Zamboni, R, Prasit, P, Chan, C ‐C

“…DFU (5,5‐dimethyl‐3‐(3‐fluorophenyl)‐4‐(4‐methylsulphonyl)phenyl‐2(5H)‐furanone) was identified as a novel orally active and highly selective cyclo‐oxygenase‐2…”
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Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach by Chan, C C, Boyce, S, Brideau, C, Ford-Hutchinson, A W, Gordon, R, Guay, D, Hill, R G, Li, C S, Mancini, J, Penneton, M

“…Recent studies have shown that there are two isoforms of cyclooxygenases. The constitutive form, cyclooxygenase 1 (COX-1), is believed to be involved in the…”
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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles by Chan, C C, Boyce, S, Brideau, C, Charleson, S, Cromlish, W, Ethier, D, Evans, J, Ford-Hutchinson, A W, Forrest, M J, Gauthier, J Y, Gordon, R, Gresser, M, Guay, J, Kargman, S, Kennedy, B, Leblanc, Y, Leger, S, Mancini, J, O'Neill, G P, Ouellet, M, Patrick, D, Percival, M D, Perrier, H, Prasit, P, Rodger, I

“…The discoveries that cyclooxygenase (COX)-2 is an inducible form of COX involved in inflammation and that COX-1 is the major isoform responsible for the…”
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The discovery of rofecoxib, [MK 966, VIOXX ®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5 H)-furanone], an orally active cyclooxygenase-2 inhibitor by Prasit, P, Wang, Z, Brideau, C, Chan, C.-C, Charleson, S, Cromlish, W, Ethier, D, Evans, J.F, Ford-Hutchinson, A.W, Gauthier, J.Y, Gordon, R, Guay, J, Gresser, M, Kargman, S, Kennedy, B, Leblanc, Y, Léger, S, Mancini, J, O'Neill, G.P, Ouellet, M, Percival, M.D, Perrier, H, Riendeau, D, Rodger, I, Tagari, P, Thérien, M, Vickers, P, Wong, E, Xu, L.-J, Young, R.N, Zamboni, R, Boyce, S, Rupniak, N, Forrest, M, Visco, D, Patrick, D

“…The development of a COX-2 inhibitor rofecoxib (MK 966, Vioxx®) is described. It is essentially equipotent to indomethacin both in vitro and in vivo but…”
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Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis by Birder, L A, Ruan, H Z, Chopra, B, Xiang, Z, Barrick, S, Buffington, C A, Roppolo, J R, Ford, A P D W, de Groat, W C, Burnstock, G

“…Purinergic mechanisms appear to be involved in motor as well as sensory functions in the urinary bladder. ATP released from efferent nerves excites bladder…”
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Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist by Jones, T R, Zamboni, R, Belley, M, Champion, E, Charette, L, Ford-Hutchinson, A W, Frenette, R, Gauthier, J Y, Leger, S, Masson, P

“…L-660,711 (3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl) ((3-dimethyl amino-3-oxo propyl)thio)methyl)thio)propanoic acid is a potent and selective competitive…”
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A Pig Collagen Peptide Fraction. A Unique Material for Maintaining Biological Activity During Lyophilization and During Storage in the Liquid State by Gaffney, P. J., Edgell, T. A., Dawson, P. J., Ford, A. W., Stocker, K.

“…There is frequent use of human and animal proteins as stabilizers during lyophilization of a variety of biological substances with a view to long term stable…”
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Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist by Jones, T R, Labelle, M, Belley, M, Champion, E, Charette, L, Evans, J, Ford-Hutchinson, A W, Gauthier, J Y, Lord, A, Masson, P

“…Montelukast sodium (Singulair), also known as MK-0476 (1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)-ethenyl)phenyl)(3-2-(1-…”
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Increased urinary LTE4 excretion following inhalation of LTC4 and LTE4 in asthmatic subjects by Christie, PE, Tagari, P, Ford-Hutchinson, AW, Black, C, Markendorf, A, Schmitz-Schumann, M, Lee, TH

“…Urinary leukotriene E4 (LTE4) increases during exacerbations of asthma and following antigen challenge. We determined whether urinary LTE4 excretion reflects…”
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The allergens of dog. II. Identification and partial purification of a major dander allergen by Ford, A W, Kemeny, D M

“…A dog hair and dander (DHD) extract was prepared from hair obtained from mixed breeds. By SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting,…”
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Growth and neurodevelopmental outcome in extremely-low-birth-weight infants after laparotomy by CHACKO, J, FORD, W. D. A, HASLAM, R

“…Twenty-one extremely-low-birth-weight (ELBW) and premature infants (<29 weeks' gestation and/or <1,000 g) underwent emergency laparotomy for acute…”
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Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist by Gauthier, J. Y, Jones, T, Champion, E, Charette, L, Dehaven, R, Ford-Hutchinson, A. W, Hoogsteen, K, Lord, A, Masson, P

“…The enantiomers of the leukotriene D4 antagonist 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl]…”
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Effect of altitude on urinary leukotriene (LT) E4 excretion and airway responsiveness to histamine in children with atopic asthma by Christie, PE, Yntema, JL, Tagari, P, Ysselstijn, H, Ford-Hutchinson, AW, Lee, TH

“…Asthmatic subjects who are resident at altitude may experience a deterioration in lung function following a stay at sea level. To determine whether measurement…”
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The effect of carbohydrate additives in the freeze-drying of alkaline phosphatase by Ford, A W, Dawson, P J

“…Alkaline phosphatase was used as a model in studies to assess the effects of lyophilization on biological activity and molecular integrity in the presence or…”
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Characterization of the recombinant human prostanoid DP receptor and identification of L‐644,698, a novel selective DP agonist by Hamish Wright, D., Metters, Kathleen M., Abramovitz, Mark, Ford‐Hutchinson, Anthony W.

“…A human embryonic kidney cell line [HEK 293(EBNA)] stably expressing the human recombinant prostaglandin D2 (PGD2) receptor (hDP) has been characterized with…”
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Increased urinary leukotriene excretion in patients with cardiac ischemia : in vivo evidence for 5-lipoxygenase activation by CARRY, M, KORLEY, V, WIILERSON, J. T, WEIGELT, L, FORD-HUTCHINSON, A. W, TAGARI, P

“…Experimental cardiac ischemia in some animal models results in the activation of the enzyme 5-lipoxygenase and the subsequent production of leukotrienes,…”
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Innovations in drug research: inhibitors of thromboxane and leukotrienes by Ford-Hutchinson, A W

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L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor by Gillard, J, Ford-Hutchinson, A W, Chan, C, Charleson, S, Denis, D, Foster, A, Fortin, R, Leger, S, McFarlane, C S, Morton, H

“…L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2, 2-dimethylpropanoic acid) is a potent inhibitor of leukotriene (LT) biosynthesis in…”
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Antenatal betamethasone and favourable outcomes in fetuses with 'poor prognosis' diaphragmatic hernia by FORD, W. D. A, KIRBY, C. P, WILKINSON, C. S, FURNESS, M. E, SLATER, A. J

“…Congenital diaphragmatic hernia (CDH) is a common abnormality affecting 1 in 2,000 gestations. The mortality exceeds 50% despite recent advances in postnatal…”
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