Central hypoventilation as the presenting symptom in Hu associated paraneoplastic encephalomyelitis

Central hypoventilation is usually caused by ischaemic or neoplastic lesions of the medulla and upper cervical spinal cord. An autoimmune disorder is not usually considered in the differential diagnosis of this syndrome. We retrospectively identified 14 patients from our database of 202 patients wit...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of neurology, neurosurgery and psychiatry Vol. 78; no. 10; pp. 1143 - 1145
Main Authors:	Gómez-Choco, Manuel J, Zarranz, Juan J, Saiz, Albert, Forcadas, María I, Graus, Francesc
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group Ltd 01-10-2007 BMJ BMJ Publishing Group LTD BMJ Group
Subjects:	Aged Airway management Antibodies Antigens Autopsies Biological and medical sciences Brain cancer Bronchoscopy Chemotherapy ELAV Proteins - blood ELAV-Like Protein 4 Emergency medical care Encephalomyelitis Fatal Outcome Female Gait Human viral diseases Humans Hypoventilation Immunoglobulins Infectious diseases Intubation Lung cancer Lymphatic system Male Medical imaging Medical sciences Middle Aged Neurology Ostomy Paraneoplastic Syndromes, Nervous System - complications Paraneoplastic Syndromes, Nervous System - diagnosis Paraneoplastic Syndromes, Nervous System - immunology Paresis Patients Prostate Respiration Respiratory failure Respiratory Insufficiency - etiology Retrospective Studies Short Report Sleep Sleep Apnea, Central - etiology Tracheotomy Tumors of the nervous system. Phacomatoses Ventilators Viral diseases Viral diseases of the nervous system Nervous system diseases Paraneoplastic syndrome Encephalomyelitis Spinal cord disease Central nervous system disease Cerebral disorder
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Central hypoventilation is usually caused by ischaemic or neoplastic lesions of the medulla and upper cervical spinal cord. An autoimmune disorder is not usually considered in the differential diagnosis of this syndrome. We retrospectively identified 14 patients from our database of 202 patients with Hu antibodies who presented with brainstem symptoms. Three were admitted to hospital because of central hypoventilation. All underwent intubation and mechanical ventilation. They could breathe properly while they were awake but suffered deep apnoeas during sleep. Two died, but one is still alive requiring ventilatory assistance during sleep. Autopsy was performed in one of the patients which showed severe inflammatory infiltrates and neuronal loss in the medulla. All patients had normal brain imaging studies and the cause of central hypoventilation was an unsolved problem until Hu antibodies were determined.
Bibliography:	PMID:17878194 istex:2B393010C65EAFDA9F4AB491502D2737C69D2147 ark:/67375/NVC-3NF0Q30L-L local:jnnp;78/10/1143 ArticleID:jn117994 href:jnnp-78-1143.pdf ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.2007.117994