Search Results - "Forbes, Robert A"

Pharmacokinetics, tolerability and safety of aripiprazole once-monthly in adult schizophrenia: An open-label, parallel-arm, multiple-dose study by Mallikaarjun, Suresh, Kane, John M, Bricmont, Patricia, McQuade, Robert, Carson, William, Sanchez, Raymond, Forbes, Robert A, Fleischhacker, W. Wolfgang

“…Abstract This 24-week, open-label, Phase Ib, parallel-arm, multiple-dose trial assessed the pharmacokinetics, safety and tolerability of a once-monthly…”
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Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis by Lu, Huasheng, Forbes, Robert A., Verma, Ajay

“…Cancer cells display high rates of aerobic glycolysis, a phenomenon known historically as the Warburg effect. Lactate and pyruvate, the end products of…”
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Aripiprazole for the treatment of pediatric bipolar I disorder: a 30-week, randomized, placebo-controlled study by Findling, Robert L, Correll, Christoph U, Nyilas, Margaretta, Forbes, Robert A, McQuade, Robert D, Jin, Na, Ivanova, Svetlana, Mankoski, Raymond, Carson, William H, Carlson, Gabrielle A

“…Objective:  To evaluate the long‐term efficacy, safety, and tolerability of aripiprazole in pediatric subjects with bipolar I disorder. Methods:  A randomized,…”
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Functional potencies of dopamine agonists and antagonists at human dopamine D2 and D3 receptors by TADORI, Yoshihiro, FORBES, Robert A, MCQUADE, Robert D, KIKUCHI, Tetsuro

“…We measured the functional agonist potencies of dopamine agonists including antiparkinson drugs, and functional antagonist potencies of antipsychotics at human…”
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Diazoxide-Induced Cardioprotection Requires Signaling Through a Redox-Sensitive Mechanism by Forbes, Robert A, Steenbergen, Charles, Murphy, Elizabeth

“…Diazoxide, a selective opener of the mitochondrial ATP-sensitive potassium channel, has been shown to elicit tolerance to ischemia in cardiac myocytes and in…”
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Characterization of aripiprazole partial agonist activity at human dopamine D3 receptors by TADORI, Yoshihiro, FORBES, Robert A, MCQUADE, Robert D, KIKUCHI, Tetsuro

“…Aripiprazole is the first dopamine D2/D3 receptor partial agonist approved for use in the treatment of psychiatric disorders, including schizophrenia, bipolar…”
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Early Antipsychotic Response to Aripiprazole in Adolescents With Schizophrenia: Predictive Value for Clinical Outcomes by Correll, Christoph U., M.D, Zhao, Joan, Ph.D, Carson, William, M.D, Marcus, Ron, M.D, McQuade, Robert, Ph.D, Forbes, Robert A., Ph.D, Mankoski, Raymond, M.D

“…Objective In adults with chronic schizophrenia, most symptom decreases occur in the first few weeks of antipsychotic treatment, and nonresponse at week 2…”
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Efficacy and safety of adjunctive aripiprazole in major depressive disorder in older patients: a pooled subpopulation analysis by Steffens, David C., Nelson, J. Craig, Eudicone, James M., Andersson, Candace, Yang, Huyuan, Tran, Quynh-Van, Forbes, Robert A., Carlson, Berit X., Berman, Robert M.

“…Objectives To evaluate the efficacy and safety of adjunctive aripiprazole compared with standard antidepressant therapy (ADT) for older patients with major…”
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Stereoselective high-performance liquid chromatography and analytical method characterization of evacetrapib using a brush-type chiral stationary phase: A challenging isomeric separation requiring a unique eluent system by Sharp, V. Scott, Stafford, John D., Forbes, Robert A., Gokey, Megan A., Cooper, Mary R.

“…•A brief history of the Whelk-O 1 chiral stationary phase is presented.•Separation of evacetrapib from three isomers and multiple synthetic impurities.•Novel…”
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Differences in agonist/antagonist properties at human dopamine D2 receptors between aripiprazole, bifeprunox and SDZ 208-912 by TADORI, Yoshihiro, KITAGAWA, Hisashi, FORBES, Robert A, MCQUADE, Robert D, STARK, Arlene, KIKUCHI, Tetsuro

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Intent-to-Treat Analysis of Health Care Expenditures of Patients Treated With Atypical Antipsychotics as Adjunctive Therapy in Depression by Jing, Yonghua, PhD, Kalsekar, Iftekhar, PhD, Curkendall, Suellen M., PhD, Carls, Ginger S., PhD, Bagalman, Erin, MSW, Forbes, Robert A., PhD, Hebden, Tony, PhD, Thase, Michael E., MD

“…Abstract Objective To compare health care utilization and expenditures in patients with depression whose initial antidepressant (AD) treatment was augmented…”
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Aripiprazole Intramuscular Depot as Maintenance Treatment in Patients With Schizophrenia: A 52-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study by KANE, John M, SANCHEZ, Raymond, PERRY, Pamela P, NA JIN, JOHNSON, Brian R, FORBES, Robert A, MCQUADE, Robert D, CARSON, William H, WOLFGANG FLEISCHHACKER, W

“…To evaluate the efficacy and tolerability of a once-monthly intramuscular (IM) depot formulation of the dopamine partial agonist aripiprazole as maintenance…”
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An open-label, positron emission tomography study of the striatal D 2 /D 3 receptor occupancy and pharmacokinetics of single-dose oral brexpiprazole in healthy participants by Wong, Dean F, Raoufinia, Arash, Bricmont, Patricia, Brašić, James R, McQuade, Robert D, Forbes, Robert A, Kikuchi, Tetsuro, Kuwabara, Hiroto

“…The aim of this Phase 1, open-label, positron emission tomography (PET) study was to determine the degree of striatal D /D receptor occupancy induced by the…”
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Acute treatment of pediatric bipolar I disorder, manic or mixed episode, with aripiprazole: a randomized, double-blind, placebo-controlled study by Findling, Robert L, Nyilas, Margaretta, Forbes, Robert A, McQuade, Robert D, Jin, Na, Iwamoto, Taro, Ivanova, Svetlana, Carson, William H, Chang, Kiki

“…To determine the efficacy and safety of aripiprazole for the treatment of pediatric bipolar I disorder, manic or mixed episode, with or without psychotic…”
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A Multiple-Center, Randomized, Double-Blind, Placebo-Controlled Study of Oral Aripiprazole for Treatment of Adolescents With Schizophrenia by Findling, Robert L., Robb, Adelaide, Nyilas, Margaretta, Forbes, Robert A., Jin, Na, Ivanova, Svetlana, Marcus, Ronald, McQuade, Robert D., Iwamoto, Taro, Carson, William H.

“…Objective: Aripiprazole is a dopamine partial agonist approved for use in adults for short- and long-term treatment of schizophrenia and bipolar disorder. This…”
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An open-label, positron emission tomography study of the striatal D2/D3 receptor occupancy and pharmacokinetics of single-dose oral brexpiprazole in healthy participants by Wong, Dean F., Raoufinia, Arash, Bricmont, Patricia, Brašić, James R., McQuade, Robert D., Forbes, Robert A., Kikuchi, Tetsuro, Kuwabara, Hiroto

“…Purpose The aim of this Phase 1, open-label, positron emission tomography (PET) study was to determine the degree of striatal D 2 /D 3 receptor occupancy…”
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Aripiprazole treatment of irritability associated with autistic disorder and the relationship between prior antipsychotic exposure, adverse events, and weight change by Mankoski, Raymond, Stockton, Gwen, Manos, George, Marler, Sabrina, McQuade, Robert, Forbes, Robert A, Marcus, Ronald

“…The purpose of this study was to evaluate the impact of prior antipsychotic exposure (PAE) on safety and tolerability outcomes in pediatric subjects receiving…”
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Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors by TADORI, Yoshihiro, FORBES, Robert A, MCQUADE, Robert D, KIKUCHI, Tetsuro

“…Aripiprazole is the first dopamine D(2)/D(3) receptor partial agonist approved for use in the treatment of psychiatric disorders including schizophrenia,…”
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Long-term safety and tolerability of aripiprazole once-monthly in maintenance treatment of patients with schizophrenia by Fleischhacker, W Wolfgang, Sanchez, Raymond, Johnson, Brian, Jin, Na, Forbes, Robert A, McQuade, Robert, Baker, Ross A, Carson, William, Kane, John M

“…The aim of this study was to evaluate the safety and tolerability of aripiprazole once-monthly (ARI-OM) for the maintenance treatment of schizophrenia. This…”
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Clinical significance of treatment effects with aripiprazole versus placebo in a study of manic or mixed episodes associated with pediatric bipolar I disorder by Youngstrom, Eric, Zhao, Joan, Mankoski, Raymond, Forbes, Robert A, Marcus, Ronald M, Carson, William, McQuade, Robert, Findling, Robert L

“…Published studies in adult and pediatric bipolar disorder have used different definitions of treatment response. This analysis aimed to compare different…”
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