Search Results - "Forbeck, Erin"
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A Regio- and Stereoselective Approach to Quaternary Centers from Chiral Trisubstituted Aziridines
Published in Journal of the American Chemical Society (21-11-2007)“…A thorough investigation of a regio- and stereospecific aziridine ring opening reaction presents new synthetic technology for the construction of a variety of…”
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Journal Article -
2
GS-Nitroxide (JP4-039)-Mediated Radioprotection of Human Fanconi Anemia Cell Lines
Published in Radiation research (01-11-2011)“…Fanconi anemia (FA) is an inherited disorder characterized by defective DNA repair and cellular sensitivity to DNA crosslinking agents. Clinically, FA is…”
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Journal Article -
3
Trisubstituted Aziridine Ring-Opening by Phenol Derivatives: Stereo- and Regioselective Formation of Chiral Tertiary Alkyl-Aryl Ethers
Published in Organic letters (26-10-2006)“…An unprecedented stereo- and regioselective trisubstituted aziridine ring-opening by phenol derivatives was discovered. The reaction features very mild…”
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Journal Article -
4
Identification of a selective small molecule inhibitor of breast cancer stem cells
Published in Bioorganic & medicinal chemistry letters (15-05-2012)“…A high-throughput screen (HTS) with the National Institute of Health–Molecular Libraries Small Molecule Repository (NIH–MLSMR) compound collection identified a…”
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Journal Article -
5
Synthesis of a Novel Suppressor of β-Cell Apoptosis via Diversity-Oriented Synthesis
Published in ACS medicinal chemistry letters (08-09-2011)“…The synthesis of a stereochemically diverse library of medium-sized rings accessible via a “build/couple/pair” strategy is described. Key aspects of the…”
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Journal Article -
6
Total synthesis and biological evaluation of ustiloxin natural products and two analogs
Published in Bioorganic & medicinal chemistry letters (15-09-2006)“…Synthetic investigations of ustiloxin natural products are described. The first total synthesis of ustiloxin F was completed in 15 steps via ethynyl aziridine…”
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Journal Article -
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Synthetic studies of heterocyclic natural products
Published in Current opinion in drug discovery & development (01-11-2008)“…Recent reports of the syntheses of heterocyclic natural products that are isolated from bacteria, fungi, plants and marine sources are discussed. This review…”
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Journal Article -
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Regio- and stereoselective synthesis of quaternary centers from chiral trisubstituted aziridines and its application toward the total synthesis of ceanothine D
Published 01-01-2009“…Most nucleophilic aziridine ring opening reactions suffer from poor regio- and stereoselectivity. A thorough investigation of a regio- and stereospecific…”
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Dissertation -
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Regio- and stereoselective synthesis of quaternary centers from chiral trisubstituted aziridines and its application toward the total synthesis of ceanothine D
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Dissertation