Search Results - "Foote, Peter K"

UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN by Park, Sungjin, Foote, Peter K., Krist, David T., Rice, Sarah E., Statsyuk, Alexander V.

“…Ring-between-ring (RBR) E3 ligases have been implicated in autoimmune disorders and neurodegenerative diseases. The functions of many RBR E3s are poorly…”
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Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection by Wolski, David, Foote, Peter K., Chen, Diana Y., Lewis-Ximenez, Lia L., Fauvelle, Catherine, Aneja, Jasneet, Walker, Andreas, Tonnerre, Pierre, Torres-Cornejo, Almudena, Kvistad, Daniel, Imam, Sabrina, Waring, Michael T., Tully, Damien C., Allen, Todd M., Chung, Raymond T., Timm, Jörg, Haining, W. Nicholas, Kim, Arthur Y., Baumert, Thomas F., Lauer, Georg M.

“…Distinct molecular pathways govern the differentiation of CD8+ effector T cells into memory or exhausted T cells during acute and chronic viral infection, but…”
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Abstract 3539: Establishing ubiquitylation patterns in cells: Efficient monitoring of oncogenic ubiquitylation activity by Foote, Peter K., Lu, Xiaolong, Singh, Rajesh

“…Abstract Cells regulate their internal functions by the ubiquitylation of many key proteins, especially onco-proteins and tumor suppressors. As a result,…”
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High-Throughput Screening of HECT E3 Ubiquitin Ligases Using UbFluor by Foote, Peter K, Krist, David T, Statsyuk, Alexander V

“…HECT E3 ubiquitin ligases are responsible for many human disease phenotypes and are promising drug targets; however, screening assays for HECT E3 inhibitors…”
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UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis by Krist, David T, Foote, Peter K, Statsyuk, Alexander V

“…HECT E3 ubiquitin ligases (∼28 are known) are associated with many phenotypes in eukaryotes and are important drug targets. However, assays used to screen for…”
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