Search Results - "Foo, Shane"

ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment by Dillon, Magnus T, Bergerhoff, Katharina F, Pedersen, Malin, Whittock, Harriet, Crespo-Rodriguez, Eva, Patin, Emmanuel C, Pearson, Alex, Smith, Henry G, Paget, James T E, Patel, Radhika R, Foo, Shane, Bozhanova, Galabina, Ragulan, Chanthirika, Fontana, Elisa, Desai, Krisha, Wilkins, Anna C, Sadanandam, Anguraj, Melcher, Alan, McLaughlin, Martin, Harrington, Kevin J

“…ATR inhibitors (ATRi) are in early phase clinical trials and have been shown to sensitize to chemotherapy and radiotherapy preclinically. Limited data have…”
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Vessel co‐option is common in human lung metastases and mediates resistance to anti‐angiogenic therapy in preclinical lung metastasis models by Bridgeman, Victoria L, Vermeulen, Peter B, Foo, Shane, Bilecz, Agnes, Daley, Frances, Kostaras, Eleftherios, Nathan, Mark R, Wan, Elaine, Frentzas, Sophia, Schweiger, Thomas, Hegedus, Balazs, Hoetzenecker, Konrad, Renyi‐Vamos, Ferenc, Kuczynski, Elizabeth A, Vasudev, Naveen S, Larkin, James, Gore, Martin, Dvorak, Harold F, Paku, Sandor, Kerbel, Robert S, Dome, Balazs, Reynolds, Andrew R

“…Anti‐angiogenic therapies have shown limited efficacy in the clinical management of metastatic disease, including lung metastases. Moreover, the mechanisms via…”
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Ephrin-B2 Controls Cell Motility and Adhesion during Blood-Vessel-Wall Assembly by Foo, Shane S., Turner, Christopher J., Adams, Susanne, Compagni, Amelia, Aubyn, Deborah, Kogata, Naoko, Lindblom, Per, Shani, Moshe, Zicha, Daniel, Adams, Ralf H.

“…New blood vessels are initially formed through the assembly or sprouting of endothelial cells, but the recruitment of supporting pericytes and vascular smooth…”
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SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells by Oliemuller, Erik, Newman, Richard, Tsang, Siu Man, Foo, Shane, Muirhead, Gareth, Noor, Farzana, Haider, Syed, Aurrekoetxea-Rodríguez, Iskander, Vivanco, Maria dM, Howard, Beatrice A

“…SOX11 is an embryonic mammary epithelial marker that is normally silenced prior to birth. High levels in breast tumours are significantly associated with…”
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Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy by Patin, Emmanuel C., Nenclares, Pablo, Chan Wah Hak, Charleen, Dillon, Magnus T., Patrikeev, Anton, McLaughlin, Martin, Grove, Lorna, Foo, Shane, Soliman, Heba, Barata, Joao P., Marsden, Joanna, Baldock, Holly, Gkantalis, Jim, Roulstone, Victoria, Kyula, Joan, Burley, Amy, Hubbard, Lisa, Pedersen, Malin, Smith, Simon A., Clancy-Thompson, Eleanor, Melcher, Alan A., Ono, Masahiro, Rullan, Antonio, Harrington, Kevin J.

“…The combination of radiotherapy/chemoradiotherapy and immune checkpoint blockade can result in poor outcomes in patients with locally advanced head and neck…”
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Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling by Armstrong, Edward, Chiu, Matthew K L, Foo, Shane, Appleton, Lizzie, Nenclares, Pablo, Patrikeev, Anton, Mohan, Nitya, Mclaughlin, Martin, Bozhanova, Galabina, Hoebart, Julia, Roulstone, Victoria, Patin, Emmanuel, Pedersen, Malin, Kyula, Joan, Ono, Masahiro, Errington-Mais, Fiona, Bell, John, Harrington, Kevin J, Melcher, Alan, Jennings, Victoria

“…BackgroundOver the past decade, cancer immunotherapies have revolutionized the treatment of melanoma; however, responses vary across patient populations…”
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CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma by Bozhanova, Galabina, Hassan, Jehanne, Appleton, Lizzie, Jennings, Victoria, Foo, Shane, McLaughlin, Martin, Chan Wah Hak, Charleen Ml, Patin, Emmanuel C, Crespo-Rodriguez, Eva, Baker, Gabby, Armstrong, Edward, Chiu, Matthew, Pandha, Hardev, Samson, Adel, Roulstone, Victoria, Kyula, Joan, Vile, Richard, Errington-Mais, Fiona, Pedersen, Malin, Harrington, Kevin, Ono, Masahiro, Melcher, Alan

“…Combination herpes simplex virus (HSV) oncolytic virotherapy and BRAF inhibitors (BRAFi) represent promising immunogenic treatments for BRAF mutant melanoma,…”
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Combining BRAF inhibition with oncolytic herpes simplex virus enhances the immune-mediated antitumor therapy of BRAF-mutant thyroid cancer by Crespo-Rodriguez, Eva, Bergerhoff, Katharina, Bozhanova, Galabina, Foo, Shane, Patin, Emmanuel C, Whittock, Harriet, Buus, Richard, Haider, Syed, Muirhead, Gareth, Thway, Khin, Newbold, Kate, Coffin, Robert S, Vile, Richard G, Kim, Dae, McLaughlin, Martin, Melcher, Alan A, Harrington, Kevin J, Pedersen, Malin

“…BackgroundThe aggressive clinical behavior of poorly differentiated and anaplastic thyroid cancers (PDTC and ATC) has proven challenging to treat, and survival…”
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Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases by Frentzas, Sophia, Simoneau, Eve, Bridgeman, Victoria L, Vermeulen, Peter B, Foo, Shane, Kostaras, Eleftherios, Nathan, Mark R, Wotherspoon, Andrew, Gao, Zu-hua, Shi, Yu, Van den Eynden, Gert, Daley, Frances, Peckitt, Clare, Tan, Xianming, Salman, Ayat, Lazaris, Anthoula, Gazinska, Patrycja, Berg, Tracy J, Eltahir, Zak, Ritsma, Laila, van Rheenen, Jacco, Khashper, Alla, Brown, Gina, Nyström, Hanna, Sund, Malin, Van Laere, Steven, Loyer, Evelyne, Dirix, Luc, Cunningham, David, Metrakos, Peter, Reynolds, Andrew R

“…Poor responses of liver metastases to the anti-angiogenic agent bevacizumab in patients with colorectal and breast cancer correlate with tumor co-option of…”
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Combination therapy with oncolytic viruses and immune checkpoint inhibitors by Chiu, Matthew, Armstrong, Edward John Lloyd, Jennings, Vicki, Foo, Shane, Crespo-Rodriguez, Eva, Bozhanova, Galabina, Patin, Emmanuel Christian, McLaughlin, Martin, Mansfield, David, Baker, Gabriella, Grove, Lorna, Pedersen, Malin, Kyula, Joan, Roulstone, Victoria, Wilkins, Anna, McDonald, Fiona, Harrington, Kevin, Melcher, Alan

“…: Immune checkpoint inhibitors (ICI) have dramatically improved the outcome for cancer patients across multiple tumor types. However the response rates to ICI…”
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The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis by Clarke, Cassie J., Berg, Tracy J., Birch, Joanna, Ennis, Darren, Mitchell, Louise, Cloix, Catherine, Campbell, Andrew, Sumpton, David, Nixon, Colin, Campbell, Kirsteen, Bridgeman, Victoria L., Vermeulen, Peter B., Foo, Shane, Kostaras, Eleftherios, Jones, J. Louise, Haywood, Linda, Pulleine, Ellie, Yin, Huabing, Strathdee, Douglas, Sansom, Owen, Blyth, Karen, McNeish, Iain, Zanivan, Sara, Reynolds, Andrew R., Norman, Jim C.

“…Expression of the initiator methionine tRNA (tRNAiMet) is deregulated in cancer. Despite this fact, it is not currently known how tRNAiMet expression levels…”
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Abstract 4105: Dissecting the mechanisms of hepatocyte replacement in breast cancer liver metastases by Nathan, Mark R., Kostaras, Lefteris, Bridgeman, Victoria, Foo, Shane, Vermeulen, Peter, Reynolds, Andrew

“…Abstract The liver is a common site of metastasis in metastatic breast cancer and is associated with significant mortality. Histopathological examination of…”
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Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma by Bridgeman, Victoria L, Wan, Elaine, Foo, Shane, Nathan, Mark R, Welti, Jonathan C, Frentzas, Sophia, Vermeulen, Peter B, Preece, Natasha, Springer, Caroline J, Powles, Thomas, Nathan, Paul D, Larkin, James, Gore, Martin, Vasudev, Naveen S, Reynolds, Andrew R

“…Sunitinib and pazopanib are antiangiogenic tyrosine kinase inhibitors (TKI) used to treat metastatic renal cell carcinoma (RCC). However, the ability of these…”
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Contrasting effects of sunitinib within in vivo models of metastasis by Welti, Jonathan C., Powles, Thomas, Foo, Shane, Gourlaouen, Morgane, Preece, Natasha, Foster, Julie, Frentzas, Sophia, Bird, Demelza, Sharpe, Kevin, van Weverwijk, Antoinette, Robertson, David, Soffe, Julie, Erler, Janine T., Pili, Roberto, Springer, Caroline J., Mather, Stephen J., Reynolds, Andrew R.

“…Sunitinib is a potent and clinically approved tyrosine kinase inhibitor that can suppress tumour growth by inhibiting angiogenesis. However, conflicting data…”
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Abstract 2997: Vessel co-option in colorectal cancer liver metastases mediates resistance to VEGF-targeted therapy by Frentzas, Sophia, Thompson, Victoria L., Vermeulen, Peter B., Foo, Shane, Brown, Gina, Cunningham, David, Reynolds, Andrew R.

“…Abstract The purpose of this study is to: (1) examine whether vessel co-option is associated with a lack of response to anti-angiogenic therapy in advanced…”
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Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models: Vessel co-option in lung metastases by Bridgeman, Victoria L, Vermeulen, Peter B, Foo, Shane, Bilecz, Agnes, Daley, Frances, Kostaras, Eleftherios, Nathan, Mark R, Wan, Elaine, Frentzas, Sophia, Schweiger, Thomas, Hegedus, Balazs, Hoetzenecker, Konrad, Renyi-Vamos, Ferenc, Kuczynski, Elizabeth A, Vasudev, Naveen S, Larkin, James, Gore, Martin, Dvorak, Harold F, Paku, Sandor, Kerbel, Robert S, Dome, Balazs, Reynolds, Andrew R

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IDENTIFICATION OF A HISTAMINE H4 RECEPTOR ON HUMAN EOSINOPHILS-ROLE IN EOSINOPHIL CHEMOTAXIS by O'Reilly, Mark, Alpert, Robbin, Jenkinson, Stephen, Gladue, Ronald P., Foo, Shane, Trim, Steven, Peter, Beate, Trevethick, Mike, Fidock, Mark

“…ABSTRACT Eosinophils are recruited to sites of inflammation via the action of a number of chemical mediators, including PAF, leukotrienes, eotaxins, ECF-A and…”
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IDENTIFICATION OF A HISTAMINE H 4 RECEPTOR ON HUMAN EOSINOPHILS—ROLE IN EOSINOPHIL CHEMOTAXIS by O'Reilly, Mark, Alpert, Robbin, Jenkinson, Stephen, Gladue, Ronald P., Foo, Shane, Trim, Steven, Peter, Beate, Trevethick, Mike, Fidock, Mark

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Control of blood vessel wall assembly by Eph/ephrin molecules by Foo, Shane S, Turner, Christopher, Schmidt, Tim, Adams, Susanne, Compagni, Amelia, Zicha, Daniel, Shani, Moshe, Adams, Ralf H

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The role of ephrinB2 in blood vessel development by Foo, Shane Siang Chin

“…The development of the vascular network is a complex process that is controlled by precisely balanced angiogenic and anti-angiogenic factors. Several studies…”
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