Search Results - "Fonville, Natalie C."

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  1. 1

    A Switch from High-Fidelity to Error-Prone DNA Double-Strand Break Repair Underlies Stress-Induced Mutation by Ponder, Rebecca G., Fonville, Natalie C., Rosenberg, Susan M.

    Published in Molecular cell (16-09-2005)
    “…Special mechanisms of mutation are induced in microbes under growth-limiting stress causing genetic instability, including occasional adaptive mutations that…”
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  2. 2

    Role of RecA and the SOS response in thymineless death in Escherichia coli by Fonville, Natalie C, Bates, David, Hastings, P J, Hanawalt, Philip C, Rosenberg, Susan M

    Published in PLoS genetics (01-03-2010)
    “…Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when…”
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  3. 3

    Exome-wide somatic microsatellite variation is altered in cells with DNA repair deficiencies by Vaksman, Zalman, Fonville, Natalie C, Tae, Hongseok, Garner, Harold R

    Published in PloS one (17-11-2014)
    “…Microsatellites (MST), tandem repeats of 1-6 nucleotide motifs, are mutational hot-spots with a bias for insertions and deletions (INDELs) rather than single…”
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  4. 4

    Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells by Hastings, P J, Hersh, Megan N, Thornton, P C, Fonville, Natalie C, Slack, Andrew, Frisch, Ryan L, Ray, Mellanie P, Harris, Reuben S, Leal, Suzanne M, Rosenberg, Susan M

    Published in PloS one (27-05-2010)
    “…Escherichia coli has five DNA polymerases, one of which, the low-fidelity Pol IV or DinB, is required for stress-induced mutagenesis in the well-studied Lac…”
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  5. 5

    Stress-induced modulators of repeat instability and genome evolution by Fonville, Natalie C, Ward, R Matthew, Mittelman, David

    “…Evolution hinges on the ability of organisms to adapt to their environment. A key regulator of adaptability is mutation rate, which must be balanced to…”
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  6. 6

    Genomic leftovers: identifying novel microsatellites, over-represented motifs and functional elements in the human genome by Fonville, Natalie C., Velmurugan, Karthik Raja, Tae, Hongseok, Vaksman, Zalman, McIver, Lauren J., Garner, Harold R.

    Published in Scientific reports (09-06-2016)
    “…The human genome is 99% complete. This study contributes to filling the 1% gap by enriching previously unknown repeat regions called microsatellites (MST). We…”
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  7. 7

    Pathways of resistance to thymineless death in Escherichia coli and the function of UvrD by Fonville, Natalie C, Vaksman, Zalman, DeNapoli, Jessica, Hastings, P J, Rosenberg, Susan M

    Published in Genetics (Austin) (01-09-2011)
    “…Thymineless death (TLD) is the rapid loss of viability in bacterial, yeast, and human cells starved of thymine. TLD is the mode of action of common anticancer…”
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  8. 8

    Population analysis of microsatellite genotypes reveals a signature associated with ovarian cancer by Fonville, Natalie C, Vaksman, Zalman, McIver, Lauren J, Garner, Harold R

    Published in Oncotarget (10-05-2015)
    “…Ovarian cancer (OV) ranks fifth in cancer deaths among women, yet there remain few informative biomarkers for this disease. Microsatellites are repetitive…”
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  9. 9

    Dysfunctional DNA repair pathway via defective FANCD2 gene engenders multifarious exomic and transcriptomic effects in Fanconi anemia by Velmurugan, Karthik Raja, Michalak, Pawel, Kang, Lin, Fonville, Natalie C., Garner, Harold R.

    Published in Molecular genetics & genomic medicine (01-11-2018)
    “…Background Fanconi anemia (FA) affects only one in 130,000 births, but has severe and diverse clinical consequences. It has been theorized that defects in the…”
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  10. 10

    Thymineless death is inhibited by CsrA in Escherichia coli lacking the SOS response by Hamilton, Holly M., Wilson, Ray, Blythe, Martin, Nehring, Ralf B., Fonville, Natalie C., Louis, Edward J., Rosenberg, Susan M.

    Published in DNA repair (01-11-2013)
    “…•Differing results in previous literature on SOS in thymineless death are resolved.•Whole-genome sequencing identifies mutation that masks SOS role in…”
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  11. 11

    RecQ-dependent death-by-recombination in cells lacking RecG and UvrD by Fonville, Natalie C., Blankschien, Matthew D., Magner, Daniel B., Rosenberg, Susan M.

    Published in DNA repair (04-04-2010)
    “…Maintenance of genomic stability is critical for all cells. Homologous recombination (HR) pathways promote genome stability using evolutionarily conserved…”
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  12. 12

    Abstract 553: Microsatellite genotyping enables precision lung cancer risk classification by Varghese, Robin T., Velmurugan, Karthik Raja, Fonville, Natalie C., Garner, Harold R.

    Published in Cancer research (Chicago, Ill.) (01-07-2017)
    “…There remains a large discrepancy between the known genetic contributions to cancer and that which can be explained by genomic variants, both inherited and…”
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  13. 13

    Exome-Wide Somatic Microsatellite Variation Is Altered in Cells with DNA Repair Deficiencies: e110263 by Vaksman, Zalman, Fonville, Natalie C, Tae, Hongseok, Garner, Harold R

    Published in PloS one (01-11-2014)
    “…Microsatellites (MST), tandem repeats of 1-6 nucleotide motifs, are mutational hot-spots with a bias for insertions and deletions (INDELs) rather than single…”
    Get full text
    Journal Article
  14. 14

    Role of RecA and the SOS Response in Thymineless Death in Escherichia coli: e1000865 by Fonville, Natalie C, Bates, David, Hastings, P J, Hanawalt, Philip C, Rosenberg, Susan M

    Published in PLoS genetics (01-03-2010)
    “…Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when…”
    Get full text
    Journal Article