Search Results - "Fonville, Natalie C."
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A Switch from High-Fidelity to Error-Prone DNA Double-Strand Break Repair Underlies Stress-Induced Mutation
Published in Molecular cell (16-09-2005)“…Special mechanisms of mutation are induced in microbes under growth-limiting stress causing genetic instability, including occasional adaptive mutations that…”
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Role of RecA and the SOS response in thymineless death in Escherichia coli
Published in PLoS genetics (01-03-2010)“…Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when…”
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3
Exome-wide somatic microsatellite variation is altered in cells with DNA repair deficiencies
Published in PloS one (17-11-2014)“…Microsatellites (MST), tandem repeats of 1-6 nucleotide motifs, are mutational hot-spots with a bias for insertions and deletions (INDELs) rather than single…”
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4
Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells
Published in PloS one (27-05-2010)“…Escherichia coli has five DNA polymerases, one of which, the low-fidelity Pol IV or DinB, is required for stress-induced mutagenesis in the well-studied Lac…”
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Stress-induced modulators of repeat instability and genome evolution
Published in Journal of molecular microbiology and biotechnology (01-01-2011)“…Evolution hinges on the ability of organisms to adapt to their environment. A key regulator of adaptability is mutation rate, which must be balanced to…”
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Genomic leftovers: identifying novel microsatellites, over-represented motifs and functional elements in the human genome
Published in Scientific reports (09-06-2016)“…The human genome is 99% complete. This study contributes to filling the 1% gap by enriching previously unknown repeat regions called microsatellites (MST). We…”
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Pathways of resistance to thymineless death in Escherichia coli and the function of UvrD
Published in Genetics (Austin) (01-09-2011)“…Thymineless death (TLD) is the rapid loss of viability in bacterial, yeast, and human cells starved of thymine. TLD is the mode of action of common anticancer…”
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Population analysis of microsatellite genotypes reveals a signature associated with ovarian cancer
Published in Oncotarget (10-05-2015)“…Ovarian cancer (OV) ranks fifth in cancer deaths among women, yet there remain few informative biomarkers for this disease. Microsatellites are repetitive…”
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Dysfunctional DNA repair pathway via defective FANCD2 gene engenders multifarious exomic and transcriptomic effects in Fanconi anemia
Published in Molecular genetics & genomic medicine (01-11-2018)“…Background Fanconi anemia (FA) affects only one in 130,000 births, but has severe and diverse clinical consequences. It has been theorized that defects in the…”
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Thymineless death is inhibited by CsrA in Escherichia coli lacking the SOS response
Published in DNA repair (01-11-2013)“…•Differing results in previous literature on SOS in thymineless death are resolved.•Whole-genome sequencing identifies mutation that masks SOS role in…”
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RecQ-dependent death-by-recombination in cells lacking RecG and UvrD
Published in DNA repair (04-04-2010)“…Maintenance of genomic stability is critical for all cells. Homologous recombination (HR) pathways promote genome stability using evolutionarily conserved…”
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Abstract 553: Microsatellite genotyping enables precision lung cancer risk classification
Published in Cancer research (Chicago, Ill.) (01-07-2017)“…There remains a large discrepancy between the known genetic contributions to cancer and that which can be explained by genomic variants, both inherited and…”
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Exome-Wide Somatic Microsatellite Variation Is Altered in Cells with DNA Repair Deficiencies: e110263
Published in PloS one (01-11-2014)“…Microsatellites (MST), tandem repeats of 1-6 nucleotide motifs, are mutational hot-spots with a bias for insertions and deletions (INDELs) rather than single…”
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Role of RecA and the SOS Response in Thymineless Death in Escherichia coli: e1000865
Published in PLoS genetics (01-03-2010)“…Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when…”
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