Search Results - "Fontes, Magda S. C"

Single-dose pharmacokinetics, safety, and tolerability of the dual endothelin receptor antagonist aprocitentan in subjects with moderate hepatic impairment by Fontes, Magda S. C., Dingemanse, Jasper, Halabi, Atef, Tomaszewska-Kiecana, Monika, Sidharta, Patricia N.

“…The effect of moderate hepatic impairment on the pharmacokinetics (PK), safety, and tolerability of the dual endothelin receptor antagonist aprocitentan was…”
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Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice by Kessler, Elise L, Wang, Jiong-Wei, Kok, Bart, Brans, Maike A, Nederlof, Angelique, van Stuijvenberg, Leonie, Huang, Chenyuan, Vink, Aryan, Arslan, Fatih, Efimov, Igor R, Lam, Carolyn S P, Vos, Marc A, de Kleijn, Dominique P V, Fontes, Magda S C, van Veen, Toon A B

“…Involvement of the Toll-like receptor 4 (TLR4) in maladaptive cardiac remodeling and heart failure (HF) upon pressure overload has been studied extensively,…”
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Leukocytic Toll-Like Receptor 2 Deficiency Preserves Cardiac Function And Reduces Fibrosis In Sustained Pressure Overload by Wang, Jiong-Wei, Fontes, Magda S. C., Wang, Xiaoyuan, Chong, Suet Yen, Kessler, Elise L., Zhang, Ya-Nan, de Haan, Judith J., Arslan, Fatih, de Jager, Saskia C. A., Timmers, Leo, van Veen, Toon A. B., Lam, Carolyn S. P., Kleijn, Dominique P. V. de

“…An involement of Toll-like receptor 2 (TLR2) has been established in cardiac dysfunction after acute myocardial infarction; however, its role in chronic…”
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Multiple‐Dose Pharmacokinetics, Safety, and Tolerability of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Healthy Japanese and Caucasian Subjects by Fontes, Magda S.C., Dingemanse, Jasper, Sidharta, Patricia N.

“…Aprocitentan is an orally active dual endothelin receptor antagonist currently in development for treatment of difficult‐to‐control (resistant) hypertension…”
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Changes in Cx43 and NaV1.5 expression precede the occurrence of substantial fibrosis in calcineurin-induced murine cardiac hypertrophy by Fontes, Magda S C, Raaijmakers, Antonia J A, van Doorn, Tessa, Kok, Bart, Nieuwenhuis, Sylvia, van der Nagel, Roel, Vos, Marc A, de Boer, Teun P, van Rijen, Harold V M, Bierhuizen, Marti F A

“…In mice, the calcium-dependent phosphatase calcineurin A (CnA) induces a transcriptional pathway leading to pathological cardiac hypertrophy. Interestingly,…”
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Functional consequences of abnormal Cx43 expression in the heart by Fontes, Magda S.C., van Veen, Toon A.B., de Bakker, Jacques M.T., van Rijen, Harold V.M.

“…The major gap junction protein expressed in the heart, connexin43 (Cx43), is highly remodeled in the diseased heart. Usually, Cx43 is down-regulated and…”
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CTGF knockout does not affect cardiac hypertrophy and fibrosis formation upon chronic pressure overload by Fontes, Magda S.C, Kessler, Elise L, van Stuijvenberg, Leonie, Brans, Maike A, Falke, Lucas L, Kok, Bart, Leask, Andrew, van Rijen, Harold V.M, Vos, Marc A, Goldschmeding, Roel, van Veen, Toon A.B

“…Abstract Background One of the main contributors to maladaptive cardiac remodeling is fibrosis. Connective tissue growth factor (CTGF), a matricellular protein…”
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Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent by Takanari, Hiroki, Bourgonje, Vincent J A, Fontes, Magda S C, Raaijmakers, Antonia J A, Driessen, Helen, Jansen, John A, van der Nagel, Roel, Kok, Bart, van Stuijvenberg, Leonie, Boulaksil, Mohamed, Takemoto, Yoshio, Yamazaki, Masatoshi, Tsuji, Yukiomi, Honjo, Haruo, Kamiya, Kaichiro, Kodama, Itsuo, Anderson, Mark E, van der Heyden, Marcel A G, van Rijen, Harold V M, van Veen, Toon A B, Vos, Marc A

“…In healthy hearts, ventricular gap junctions are mainly composed by connexin43 (Cx43) and localize in the intercalated disc, enabling appropriate electrical…”
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Arrhythmogenic Remodeling in Murine Models of Deoxycorticosterone Acetate-Salt-Induced and 5/6-Subtotal Nephrectomy-Salt-Induced Cardiorenal Disease by Fontes, Magda S.C., Papazova, Diana A., van Koppen, Arianne, de Jong, Sanne, Korte, Sanne M., Bongartz, Lennart G., Nguyen, Tri Q., Bierhuizen, Marti F.A., de Boer, Teun P., van Veen, Toon A.B., Verhaar, Marianne C., Joles, Jaap A., van Rijen, Harold V.M.

“…Background: Renal failure is associated with adverse cardiac remodeling and sudden cardiac death. The mechanism leading to enhanced arrhythmogenicity in the…”
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Response to the letter from Warren et al by Takanari, Hiroki, Fontes, Magda S C, van der Heyden, Marcel A G, Vos, Marc A, van Veen, Toon A B

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Changes in Cx43 and Na.sub.V1.5 Expression Precede the Occurrence of Substantial Fibrosis in Calcineurin-Induced Murine Cardiac Hypertrophy by Fontes, Magda S. C, Raaijmakers, Antonia J. A, van Doorn, Tessa, Kok, Bart, Nieuwenhuis, Sylvia, van der Nagel, Roel, Vos, Marc A, de Boer, Teun P, van Rijen, Harold V. M, Bierhuizen, Marti F. A

“…In mice, the calcium-dependent phosphatase calcineurin A (CnA) induces a transcriptional pathway leading to pathological cardiac hypertrophy. Interestingly,…”
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