SARS-CoV-2 genomic surveillance in Rondônia, Brazilian Western Amazon

SARS-CoV-2 has spread rapidly around the world, with Brazil currently considered an epicenter of the pandemic. The Northern region has the second highest incidence coefficient, as well as the third highest mortality rate in the country. This study aimed to investigate information about the evolution...

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Published in:	Scientific reports Vol. 11; no. 1; p. 3770
Main Authors:	Botelho-Souza, Luan Felipo, Nogueira-Lima, Felipe Souza, Roca, Tárcio Peixoto, Naveca, Felipe Gomes, de Oliveria dos Santos, Alcione, Maia, Adriana Cristina Salvador, da Silva, Cicileia Correia, de Melo Mendonça, Aline Linhares Ferreira, Lugtenburg, Celina Aparecida Bertoni, Azzi, Camila Flávia Gomes, Fontes, Juliana Loca Furtado, Cavalcante, Suelen, de Cássia Pontello Rampazzo, Rita, Santos, Caio Henrique Nemeth, Di Sabatino Guimarães, Alice Paula, Máximo, Fernando Rodrigues, Villalobos-Salcedo, Juan Miguel, Vieira, Deusilene Souza
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12-02-2021 Nature Publishing Group Nature Portfolio
Subjects:	631/114 631/337 Brazil COVID-19 COVID-19 - epidemiology COVID-19 - virology Epidemiology Humanities and Social Sciences Humans multidisciplinary Mutation Mutation Rate Pandemics Phylogeny Ribonucleic acid RNA SARS-CoV-2 - classification SARS-CoV-2 - genetics SARS-CoV-2 - isolation & purification Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Strains (organisms) Viral Proteins - genetics Brazil
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Summary:	SARS-CoV-2 has spread rapidly around the world, with Brazil currently considered an epicenter of the pandemic. The Northern region has the second highest incidence coefficient, as well as the third highest mortality rate in the country. This study aimed to investigate information about the evolutionary history of epidemic spread and genetic aspects of strains isolated on the Western Amazon, in the State of Rondônia, Brazil. It was possible to detect a total of 22 mutations. Some of these alterations may possibly be related to effects on transmissibility, the fidelity of RNA replication, the ability of cancer patients to respond to infection, beyond a mutation that emerged after the introduction of SARS-CoV-2 in Rondônia. At least two events of introduction were detected, corresponding to the B.1 and B.1.1 European lineages. An introduction was observed possibly through Argentina, where strains originated that circulated in the Minas Gerais and Ceará Brazilian states, prior to Rondônia (B.1.), as well as through the Minas Gerais state and the Federal District, which gave rise to strains that spread to Rondônia, from the capital to more rural parts of the state (B.1.1.). The findings show the need to monitor the genetic epidemiology of COVID-19, in order to surveil the virus’s evolution, dispersion and diversity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-83203-2