Search Results - "Fontes, Joseph"

Neuronal gap junctions: making and breaking connections during development and injury by Belousov, Andrei B, Fontes, Joseph D

“…In the mammalian central nervous system (CNS), coupling of neurons by gap junctions (i.e., electrical synapses) and the expression of the neuronal gap junction…”
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The regulation of glycogenolysis in the brain by Nadeau, Owen W., Fontes, Joseph D., Carlson, Gerald M.

“…The key regulatory enzymes of glycogenolysis are phosphorylase kinase, a hetero-oligomer with four different types of subunits, and glycogen phosphorylase, a…”
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Physician Perception of the Importance of Medical Genetics and Genomics in Medical Education and Clinical Practice by French, Emilie Logan, Kader, Leena, Young, Erin E., Fontes, Joseph D.

“…The importance of medical genetics and genomics in medical practice has grown proportionally with scientific advances in these areas. The objective of this…”
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O-GlcNAc homeostasis contributes to cell fate decisions during hematopoiesis by Zhang, Zhen, Parker, Matthew P., Graw, Stefan, Novikova, Lesya V., Fedosyuk, Halyna, Fontes, Joseph D., Koestler, Devin C., Peterson, Kenneth R., Slawson, Chad

“…The addition of a single β-d-GlcNAc sugar (O-GlcNAc) by O-GlcNAc-transferase (OGT) and O-GlcNAc removal by O-GlcNAcase (OGA) maintain homeostatic O-GlcNAc…”
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The University of Kansas School of Medicine by Bonaminio, Giulia A., Fontes, Joseph D., Doolittle, Gary, Shaw, Pam, Moser, Scott, Robinson, Michael

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A potential role for neuronal connexin 36 in the pathogenesis of amyotrophic lateral sclerosis by Belousov, Andrei B., Nishimune, Hiroshi, Denisova, Janna V., Fontes, Joseph D.

“…•A role for neuronal connexin 36 in the pathogenesis of ALS is proposed.•The mechanism relies on contribution of connexin 36 to ALS-related neuronal death.•A…”
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The intrinsically disordered transcriptional activation domain of CIITA is functionally tuneable by single substitutions: An exception or a new paradigm? by Sreenivasan, Shwetha, Heffren, Paul, Suh, Kyung‐Shin, Rodnin, Mykola V., Kosa, Edina, Fenton, Aron W., Ladokhin, Alexey S., Smith, Paul E., Fontes, Joseph D., Swint‐Kruse, Liskin

“…During protein evolution, some amino acid substitutions modulate protein function (“tuneability”). In most proteins, the tuneable range is wide and can be…”
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Neuronal gap junction coupling is regulated by glutamate and plays critical role in cell death during neuronal injury by Wang, Yongfu, Song, Ji-Hoon, Denisova, Janna V, Park, Won-Mee, Fontes, Joseph D, Belousov, Andrei B

“…In the mammalian CNS, excessive release of glutamate and overactivation of glutamate receptors are responsible for the secondary (delayed) neuronal death…”
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Equivalent Performance of Exam Items Associated with Case-Based Learning, Flipped Classroom, and Lecture in a Pre-clerkship Medical Curriculum by Hughes, Dorothy, Keim, Sarah A., Fontes, Joseph D.

“…The purpose of our study was to determine if knowledge acquisition, as measured by exam item performance, differed for active or passive learning activities in…”
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The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression by Ramsey, Jon E., Fontes, Joseph D.

“…•Transcription factor ZXDC1 promotes differentiation of the leukemia cell line U937.•ZXDC1 activates macrophage-specific and pro-inflammatory gene…”
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Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin by Fontes, Joseph D, Ramsey, Jon, Polk, Jeremy M, Koop, Andre, Denisova, Janna V, Belousov, Andrei B

“…Pharmacological blockade or genetic knockout of neuronal connexin 36 (Cx36)-containing gap junctions reduces neuronal death caused by ischemia, traumatic brain…”
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Neuronal gap junction coupling as the primary determinant of the extent of glutamate-mediated excitotoxicity by Belousov, Andrei B., Fontes, Joseph D.

“…In the mammalian central nervous system (CNS), coupling of neurons by gap junctions (electrical synapses) increases during early postnatal development, then…”
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Neuronal gap junctions are required for NMDA receptor-mediated excitotoxicity: implications in ischemic stroke by Wang, Yongfu, Denisova, Janna V, Kang, Ki Sung, Fontes, Joseph D, Zhu, Bao Ting, Belousov, Andrei B

“…N-methyl-D-aspartate receptors (NMDARs) play an important role in cell survival versus cell death decisions during neuronal development, ischemia, trauma, and…”
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Interplay of chemical neurotransmitters regulates developmental increase in electrical synapses by Park, Won-Mee, Wang, Yongfu, Park, Soodong, Denisova, Janna V, Fontes, Joseph D, Belousov, Andrei B

“…Coupling of neurons by electrical synapses (gap junctions) transiently increases in the mammalian CNS during development. We report here that the developmental…”
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Medical Student Perspectives of Active Learning: A Focus Group Study by Walling, Anne, Istas, Kathryn, Bonaminio, Giulia A., Paolo, Anthony M., Fontes, Joseph D., Davis, Nancy, Berardo, Benito A.

“…Phenomenon: Medical student perspectives were sought about active learning, including concerns, challenges, perceived advantages and disadvantages, and…”
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Neuronal gap junctions play a role in the secondary neuronal death following controlled cortical impact by Belousov, Andrei B., Wang, Yongfu, Song, Ji-Hoon, Denisova, Janna V., Berman, Nancy E., Fontes, Joseph D.

“…► Controlled cortical impact in mice induces secondary neuronal death in the striatum. ► This neuronal death is reduced by blockade of neuronal gap junctions…”
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Role of neuronal gap junctions in NMDA receptor-mediated excitotoxicity and ischemic neuronal death by Belousov, Andrei, Fontes, Joseph

“…In the mammalian central nervous system（CNS）coupling of neurons by gap junctions and the expression of neuronal gap junction protein,connexin 36（Cx36）rapidly…”
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Regulation of connexin 36 expression during development by Song, Ji-Hoon, Wang, Yongfu, Fontes, Joseph D., Belousov, Andrei B.

“…► Acute activation of group II mGluRs or ischemia both increase Cx36 protein expression. ► The regulation likely is due to new protein synthesis. ► Thus, the…”
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Obituary: Mark Thomas Fisher, Ph.D. June 21,1954–September 4, 2018 by Fontes, Joseph D.

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Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease by Belousov, Andrei B, Fontes, Joseph D, Freitas-Andrade, Moises, Naus, Christian C

“…Gap junctions are unique membrane channels that play a significant role in intercellular communication in the developing and mature central nervous system…”
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