Effects of Calendula officinalis extract on liver histopathology, lipid profile, and oxidative stress in rats submitted to a diet rich in cholesterol and carbohydrates

ABSTRACT Purpose: To evaluate the modulatory properties of Calendula officinalis L. (Asteraceae) (C. officinalis) extract on cafeteria diet-fed rats. Methods: A cafeteria diet was administered ad libitum for 45 days to induce dyslipidemia. Then, the rats were treated with the formulations containing...

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Bibliographic Details
Published in:	Acta Cirúrgica Brasileira Vol. 38
Main Authors:	Fontes, Gleide Gatti, Freitas, Rodrigo de Barros, Almeida, Palloma Porto, Lima, Luciana Moreira, Cardoso, Silvia Almeida, Pizziolo, Virginia Ramos, Tabach, Ricardo, Wanderley, Almir Gonçalves, Arida, Ricardo Mario, Caricati-Neto, Afonso, Taha, Murched Omar, Carvalho, Camilo Amaro de, Tallo, Fernando Sabia, Menezes-Rodrigues, Francisco Sandro
Format:	Journal Article
Language:	English
Published:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01-01-2023
Subjects:	Calendula Dyslipidemias Flavonoids Lipids Original Oxidative Stress
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Summary:	ABSTRACT Purpose: To evaluate the modulatory properties of Calendula officinalis L. (Asteraceae) (C. officinalis) extract on cafeteria diet-fed rats. Methods: A cafeteria diet was administered ad libitum for 45 days to induce dyslipidemia. Then, the rats were treated with the formulations containing C. officinalis in the doses of 50, 100, and 150 mg/kg or only with the vehicle formulation; the control group received a commercial ration. Results: The cafeteria diet decreased glutathione S-transferase activity and high-density lipoprotein plasmatic levels and damaged the hepatic architecture. The C. officinalis extract was able to reduce lipid infiltration in liver tissue and to modulate oxidative stress and lipid profile markers. Conclusions: The correlations between the variables suggest a pathological connection between oxidative stress markers and serum lipid profile.
Bibliography:	About the Authors: Fontes GG, Almeida PP are MSc. Freitas RB is a medicine student. Conflict of Interest: Nothing to declare. Lima LM, Cardoso SA, Pizziolo VR, Tabach R, Wanderley AG, Arida RM, Caricati-Neto A, Taha MO, Carvalho CA, Tallo FS and Menezes-Rodrigues FS are PhD
ISSN:	0102-8650 1678-2674
DOI:	10.1590/acb383723