Oxidative stress and DNA damage in older adults that do exercises regularly

Oxidative stress and DNA damage in older adults that do exercises regularly

Free radicals may damage lipids, proteins and DNA, which may lead to critical diseases in the aging. This work evaluated levels of malondialdehyde (MDA), glutathione peroxidase (GPx) and DNA damage by comet assay (SCGE) in older adults that do exercises regularly. 110 females, aged 66.3 ± 8 years we...

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Published in:Clinical biochemistry Vol. 42; no. 16; pp. 1648 - 1653
Main Authors: Mergener, Michelle, Martins, Maclóvia Rosso, Antunes, Marina Venzon, da Silva, Caroline Calice, Lazzaretti, Camilla, Fontanive, Tiago Oselane, Suyenaga, Edna Sayuri, Ardenghi, Patrícia Grolli, Maluf, Sharbel Weidner, Gamaro, Giovana Duzzo
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-11-2009
Subjects:
Aged
Comet Assay
DNA Damage
Exercise
Female
Glutathione peroxidase
Glutathione Peroxidase - metabolism
Humans
Malondialdehyde
Malondialdehyde - metabolism
Middle Aged
Older adults
Oxidative Stress
Glutathione peroxidase
Oxidative stress
Exercise
Older adults
DNA damage
Malondialdehyde
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Summary:Free radicals may damage lipids, proteins and DNA, which may lead to critical diseases in the aging. This work evaluated levels of malondialdehyde (MDA), glutathione peroxidase (GPx) and DNA damage by comet assay (SCGE) in older adults that do exercises regularly. 110 females, aged 66.3 ± 8 years were divided into sedentary ( n = 54), walking ( n = 36) and muscle building ( n = 20) groups. Levels of MDA, GPx and SCGE were measured in venous blood before and after exercise. MDA levels were higher ( P < 0.005) and GPx levels were lower ( P < 0.005) in active groups than in sedentary group. SCGE index after physical activity was greater than at baseline (muscle building: P = 0.004; walking: P = 0.002). Exercise reduces the diseases risk, but may promote the production of free radicals. It remains unclear whether cell adaptations responsible for health benefits are associated with such events. However we may suggest the existence of a different biochemical pattern for older adults that do exercise regularly.
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ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2009.08.001