Search Results - "Fontanillo, Miriam"

Structural basis of Naa20 activity towards a canonical NatB substrate by Layer, Dominik, Kopp, Jürgen, Fontanillo, Miriam, Köhn, Maja, Lapouge, Karine, Sinning, Irmgard

“…N-terminal acetylation is one of the most common protein modifications in eukaryotes and is carried out by N-terminal acetyltransferases (NATs). It plays…”
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Microcystins: Synthesis and structure–activity relationship studies toward PP1 and PP2A by Fontanillo, Miriam, Köhn, Maja

“…[Display omitted] Microcystins are highly toxic cyanotoxins responsible for plant, animal and human poisoning. Exposure to microcystins, mainly through…”
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Phosphatases: Their Roles in Cancer and Their Chemical Modulators by Fontanillo, Miriam, Köhn, Maja

“…Phosphatases are involved in basically all cellular processes by dephosphorylating cellular components such as proteins, phospholipids and second messengers…”
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Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs) by Fontanillo, Miriam, Trebacz, Malgorzata, Reinkemeier, Christopher D., Avilés Huerta, Daniela, Uhrig, Ulrike, Sehr, Peter, Köhn, Maja

“…[Display omitted] •High throughput and structure-based virtual screening assays for PP1 de-inhibition.•Optimization of a 23mer PP1-disrupting peptide to a…”
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Towards Dissecting the Mechanism of Protein Phosphatase‐1 Inhibition by Its C‐Terminal Phosphorylation by Salvi, Francesca, Hoermann, Bernhard, Pino García, Javier, Fontanillo, Miriam, Derua, Rita, Beullens, Monique, Bollen, Mathieu, Barabas, Orsolya, Köhn, Maja

“…Phosphoprotein phosphatase‐1 (PP1) is a key player in the regulation of phospho‐serine (pSer) and phospho‐threonine (pThr) dephosphorylation and is involved in…”
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Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of Protein Phosphatase (PP)2A over PP1 by Fontanillo, Miriam, Zemskov, Ivan, Häfner, Maximilian, Uhrig, Ulrike, Salvi, Francesca, Simon, Bernd, Wittmann, Valentin, Köhn, Maja

“…Research and therapeutic targeting of the phosphoserine/threonine phosphatases PP1 and PP2A is hindered by the lack of selective inhibitors. The microcystin…”
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In situ synthesis-gelation at room temperature vs. heating–cooling procedure. Fine tuning of molecular gels derived from succinic acid and L-valine by Fontanillo, Miriam, Angulo-Pachón, César A., Escuder, Beatriu, Miravet, Juan F.

“…•Molecular gels are prepared by in situ, simultaneous, synthesis and gelation.•Gel properties differ considerably between in situ and thermally prepared…”
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Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of Protein Phosphatase (PP)2A over PP1 by Fontanillo, Miriam, Zemskov, Ivan, Häfner, Maximilian, Uhrig, Ulrike, Salvi, Francesca, Simon, Bernd, Wittmann, Valentin, Köhn, Maja

“…Research and therapeutic targeting of the phosphoserine/threonine phosphatases PP1 and PP2A is hindered by the lack of selective inhibitors. The microcystin…”
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