α1-Blockers for the treatment of recurrent urinary tract infections in women with dysfunctional voiding: A prospective randomized study

Objectives To evaluate the therapeutic effects of tamsulosin on recurrent urinary tract infections in women with dysfunctional voiding. Methods A total of 155 women with recurrent urinary tract infections and dysfunctional voiding were included and randomly assigned to the following groups: uroflowm...

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Bibliographic Details
Published in:	International journal of urology Vol. 22; no. 1; pp. 115 - 121
Main Authors:	Minardi, Daniele, Pellegrinelli, Francesco, Conti, Alessandro, Fontana, Donatella, Mattia, Michela, Milanese, Giulio, Muzzonigro, Giovanni
Format:	Journal Article
Language:	English
Published:	Australia Blackwell Publishing Ltd 01-01-2015
Subjects:	Adrenergic alpha-1 Receptor Antagonists - therapeutic use Adult Aged dysfunctional voiding Female Follow-Up Studies Humans Middle Aged Prospective Studies Quality of Life recurrent urinary tract infection Sulfonamides - therapeutic use Urinary Tract Infections - complications Urinary Tract Infections - drug therapy Urination Disorders - complications Urination Disorders - drug therapy Urodynamics uroflowmetry biofeedback α1-blockers uroflowmetry biofeedback recurrent urinary tract infection dysfunctional voiding α1-blockers
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Summary:	Objectives To evaluate the therapeutic effects of tamsulosin on recurrent urinary tract infections in women with dysfunctional voiding. Methods A total of 155 women with recurrent urinary tract infections and dysfunctional voiding were included and randomly assigned to the following groups: uroflowmetry biofeedback (group 1), α1‐adrenoceptor antagonists (group 2), uroflowmetry biofeedback combined with α1‐adrenoceptor antagonists (group 3) and no treatment (group 4). Patients were evaluated by the American Urological Association Symptom Index at 3, 6 and 12 months. Urodynamics was carried out in patients of groups 1, 2, and 3 at 3, 6 and 12 months, whereas urodynamics was only carried out at 12 months in group 4. All patients were followed up for 1 year with monthly urine cultures. Results The incidence of storage and emptying symptoms decreased significantly at 3, 6 and 12 months. Mean flow rate, flow time and voiding volume increased significantly (with a better outcome in patients of group 3), whereas post‐void residual urine decreased. Mean opening detrusor pressure and detrusor pressure at maximum flow decreased significantly (with a better outcome in patients of group 3). Mean urethral closure pressure and maximum urethral closure pressure decreased significantly with a more significant decrease for patients in group 3. The prevalence of urinary tract infection decreased significantly in all groups after treatment, and this decrease remained stable during the follow up. Conclusions In women with dysfunctional voiding and recurrent urinary tract infection, tamsulosin associated with uroflowmetry biofeedback might be an effective and safe treatment option for improving urinary symptoms and quality of life.
Bibliography:	ArticleID:IJU12601 istex:51A704E1E1F317D106C6DA9363FBB42D6FE33434 ark:/67375/WNG-2VWGJDMP-J ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0919-8172 1442-2042
DOI:	10.1111/iju.12601