Multilobulated "flower" cells in a subcutaneous mass aspirate from a cat

An 8‐year‐old intact male cat was presented with a subcutaneous mass in the region of the right jugular vein. Cytologic and histopathologic examinations revealed cells with multilobulated nuclei (flower cells). Immunochemistry using a panel of markers showed vimentin‐positivity on cytologic specimen...

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Bibliographic Details
Published in:	Veterinary clinical pathology Vol. 34; no. 4; pp. 429 - 433
Main Authors:	Fritz, D., Freeman, K. P., Hopfner, C., Fontaine, O. Dela, Seroka, M., Simon, F., Musch, D., Rabeyrin, M.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-12-2005
Subjects:	Animals Cat Diseases - diagnosis Cat Diseases - metabolism Cat Diseases - pathology Cats CD79 Antigens - analysis CD79 Antigens - metabolism Cell Nucleus - pathology Flower cells immunochemistry Immunohistochemistry - methods Immunohistochemistry - veterinary Jugular Veins leukemia lymphoma Lymphoma, B-Cell - chemistry Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - pathology Lymphoma, B-Cell - veterinary Male multilobulated nuclei myeloproliferative disease Subcutaneous Tissue - pathology Vimentin - analysis
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Summary:	An 8‐year‐old intact male cat was presented with a subcutaneous mass in the region of the right jugular vein. Cytologic and histopathologic examinations revealed cells with multilobulated nuclei (flower cells). Immunochemistry using a panel of markers showed vimentin‐positivity on cytologic specimens, and postive staining for CD79a and BLA36 on histologic specimens. The final diagnosis was lymphoma of B‐cell origin. We have observed similar multilobulated cells in ascites fluid, thoracic fluid, and peripheral blood from dogs and cats with a variety of lymphoid and myeloid neoplasms. Cells with multilobulated nuclei that resemble flower petals also have been described in humans. These cells are infrequently observed in canine and feline cytology specimens and require immunochemistry to determine their cell of origin.
Bibliography:	istex:E8A33D2442C06292B9EB8380717F285F14577EFF ark:/67375/WNG-F2PPWCJV-W ArticleID:VCP429 ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0275-6382 1939-165X
DOI:	10.1111/j.1939-165X.2005.tb00076.x