Search Results - "Fontaine, Marilyn"

Trial in progress: A phase 2 study of CTX-009 in adult patients with metastatic colorectal cancer who have received two or three prior systemic chemotherapy regimens by Fontaine, Marilyn, Pilgrim, Sarah, Schuetz, Thomas

“…TPS281 Background: CTX-009 is a recombinant bispecific antibody that binds both delta-like ligand-4 (DLL4) and vascular endothelial growth factor A (VEGF-A)…”
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Trial in progress: A phase 2/3 randomized, controlled study of CTX-009 in combination with paclitaxel versus paclitaxel alone in adult patients with unresectable advanced, metastatic or recurrent biliary tract cancers who have received one prior systemic chemotherapy regimen by Fontaine, Marilyn, Pilgrim, Sarah, Schuetz, Thomas

“…TPS640 Background: CTX-009 is a recombinant bispecific antibody that binds both delta-like ligand-4 (DLL4) and vascular endothelial growth factor A (VEGF-A)…”
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Prognostic impact of pSTAT3 on overall survival (OS) in gastrointestinal (GI) cancers: Data from 3 phase 3, randomized controlled trials (RCTs) by Brooks, Emily, Lebedinsky, Claudia, Bekaii-Saab, Tanios S., Shah, Manish A., Jonker, Derek J., Kuchimanchi, Kamesh, Wybieralska, Ewa, Fontaine, Marilyn, Oh, Cindy, Sari, Suha, Foos, Emma, Xu, Bo, Hitron, Matthew

“…Abstract only 4147 Background: Retrospective studies of phosphorylated STAT3 (pSTAT3, a regulator of gene expression) in cancer-lineage cells have suggested it…”
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Randomized, Double-Blind, Placebo-Controlled Phase III Study of Paclitaxel ± Napabucasin in Pretreated Advanced Gastric or Gastroesophageal Junction Adenocarcinoma by Shah, Manish A, Shitara, Kohei, Lordick, Florian, Bang, Yung-Jue, Tebbutt, Niall C, Metges, Jean-Phillippe, Muro, Kei, Lee, Keun-Wook, Shen, Lin, Tjulandin, Sergei, Hays, John L, Starling, Naureen, Xu, Rui-Hua, Sturtz, Keren, Fontaine, Marilyn, Oh, Cindy, Brooks, Emily M, Xu, Bo, Li, Wei, Li, Chiang J, Borodyansky, Laura, Van Cutsem, Eric

“…To compare napabucasin (generator of reactive oxygen species) plus paclitaxel with paclitaxel only in patients with second-line advanced gastric or…”
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Napabucasin Plus FOLFIRI in Patients With Previously Treated Metastatic Colorectal Cancer: Results From the Open-Label, Randomized Phase III CanStem303C Study by Shah, Manish A., Yoshino, Takayuki, Tebbutt, Niall C., Grothey, Axel, Tabernero, Josep, Xu, Rui-Hua, Cervantes, Andres, Oh, Sang Cheul, Yamaguchi, Kensei, Fakih, Marwan, Falcone, Alfredo, Wu, Christina, Chiu, Vi K., Tomasek, Jiri, Bendell, Johanna, Fontaine, Marilyn, Hitron, Matthew, Xu, Bo, Taieb, Julien, Van Cutsem, Eric

“…Napabucasin is an investigational, orally administered reactive oxygen species generator bioactivated by intracellular antioxidant NAD(P)H:quinone…”
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The BRIGHTER trial: A phase 3 randomized double-blind study of napabucasin (NAPA) plus paclitaxel (PTX) versus placebo (PBO) plus PTX in patients (pts) with pretreated advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma by Shah, Manish A., Shitara, Kohei, Lordick, Florian, Bang, Yung-Jue, Tebbutt, Niall C., Metges, Jean-Philippe, Muro, Kei, Shen, Lin, Tjulandin, Sergei, Hays, John L., Xu, Rui-hua, Fontaine, Marilyn, Brooks, Emily, Xu, Bo, Li, Wei, Li, Chiang, Borodyansky, Laura, Van Cutsem, Eric

“…Abstract only…”
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Randomized, double-blind, placebo-controlled phase 3 study of paclitaxel {plus minus} napabucasin in pretreated advanced gastric or gastroesophageal junction adenocarcinoma by Shah, Manish A, Shitara, Kohei, Lordick, Florian, Bang, Yung-Jue, Tebbutt, Niall C, Metges, Jean-Phillippe, Muro, Kei, Lee, Keun-Wook, Shen, Lin, Tjulandin, Sergei, Hays, John L, Starling, Naureen, Xu, Rui-Hua, Sturtz, Keren, Fontaine, Marilyn, Oh, Cindy, Brooks, Emily, Xu, Bo, Li, Wei, Li, Chiang J, Borodyansky, Laura, Van Cutsem, Eric

“…To compare napabucasin (generator of reactive oxygen species) plus paclitaxel with paclitaxel only in patients with second-line advanced gastric or…”
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Breaking the silence by Fontaine-Brightstar, Marilyn

“…The issue of violence against aboriginal women and children was brought out by the Aboriginal Women's Unity Coalition. The Canadian group supported an…”
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