Search Results - "Fontaine, Evelyne"

"Upcycling" known molecules and targets for drug-resistant TB by Roubert, Christine, Fontaine, Evelyne, Upton, Anna M

“…Despite reinvigorated efforts in Tuberculosis (TB) drug discovery over the past 20 years, relatively few new drugs and candidates have emerged with clear…”
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Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice by Aragaw, Wassihun Wedajo, Roubert, Christine, Fontaine, Evelyne, Lagrange, Sophie, Zimmerman, Matthew D, Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas

“…Cyclohexyl-griselimycin is a preclinical candidate for use against tuberculosis (TB). Here, we show that this oral cyclodepsipeptide is also active against the…”
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Targeting DnaN for tuberculosis therapy using novel griselimycins by Kling, Angela, Lukat, Peer, Almeida, Deepak V., Bauer, Armin, Fontaine, Evelyne, Sordello, Sylvie, Zaburannyi, Nestor, Herrmann, Jennifer, Wenzel, Silke C., König, Claudia, Ammerman, Nicole C., Barrio, María Belén, Borchers, Kai, Bordon-Pallier, Florence, Brönstrup, Mark, Courtemanche, Gilles, Gerlitz, Martin, Geslin, Michel, Hammann, Peter, Heinz, Dirk W., Hoffmann, Holger, Klieber, Sylvie, Kohlmann, Markus, Kurz, Michael, Lair, Christine, Matter, Hans, Nuermberger, Eric, Tyagi, Sandeep, Fraisse, Laurent, Grosset, Jacques H., Lagrange, Sophie, Müller, Rolf

“…The discovery of Streptomyces-produced streptomycin founded the age of tuberculosis therapy. Despite the subsequent development of a curative regimen for this…”
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4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Biochemical and pharmacological characterization by Gully, Danielle, Geslin, Michel, Serva, Laurence, Fontaine, Evelyne, Roger, Pierre, Lair, Christine, Darre, Valerie, Marcy, Claudine, Rouby, Pierre-Eric, Simiand, Jacques, Guitard, Josette, Gout, Georgette, Steinberg, Regis, Rodier, Daniel, Griebel, Guy, Soubrie, Philippe, Pascal, Marc, Pruss, Rebecca, Scatton, Bernard, Maffrand, Jean-Pierre, Le Fur, Gerard

“…4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1- (3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride…”
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Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins by Kling, Angela, Lukat, Peer, Almeida, Deepak V, Bauer, Armin, Fontaine, Evelyne, Sordello, Sylvie, Zaburannyi, Nestor, Herrmann, Jennifer, Wenzel, Silke C, König, Claudia, Ammerman, Nicole C, Barrio, María Belén, Borchers, Kai, Bordon-Pallier, Florence, Brönstrup, Mark, Courtemanche, Gilles, Gerlitz, Martin, Geslin, Michel, Hammann, Peter, Heinz, Dirk W, Hoffmann, Holger, Klieber, Sylvie, Kohlmann, Markus, Kurz, Michael, Lair, Christine, Matter, Hans, Nuermberger, Eric, Tyagi, Sandeep, Fraisse, Laurent, Grosset, Jacques H, Lagrange, Sophie, Müller, Rolf

“…The discovery of Streptomyces-produced streptomycin founded the age of tuberculosis therapy. Despite the subsequent development of a curative regimen for this…”
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Synthesis of optically-active benzylic amines; asymmetric reduction of ketoxime ethers with chiral oxazaborolidines by Fontaine, Evelyne, Namane, Claudie, Meneyrol, Jérôme, Geslin, Michel, Serva, Laurence, Roussey, Eliane, Tissandié, Stéphanie, Maftouh, Mohamed, Roger, Pierre

“…The preparation of novel optically active benzylic amines by the enantioselective reduction of phenone oximes using chiral oxazaborolidine is described. The…”
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Total Synthesis of a Thymidine 2-Deoxypolyoxin C Analogue by Dehoux, Cécile, Fontaine, Evelyne, Escudier, Jean-Marc, Baltas, Michel, Gorrichon, Liliane

“…The synthesis of the thymidine 2-deoxypolyoxin C analogue 10 from a noncarbohydrate precursor was achieved in 10 steps and 9% yield starting from a chiral…”
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