Search Results - "Fonseca, Sonya"

Endoplasmic reticulum stress and pancreatic β-cell death by Fonseca, Sonya G, Gromada, Jesper, Urano, Fumihiko

“…In pancreatic β-cells, the endoplasmic reticulum (ER) is an important cellular compartment for insulin biosynthesis, which accounts for half of the total…”
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Endoplasmic reticulum stress in β-cells and development of diabetes by Fonseca, Sonya G, Burcin, Mark, Gromada, Jesper, Urano, Fumihiko

“…The endoplasmic reticulum (ER) is a cellular compartment responsible for multiple important cellular functions including the biosynthesis and folding of newly…”
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Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells by Fonseca, Sonya G, Ishigaki, Shinsuke, Oslowski, Christine M, Lu, Simin, Lipson, Kathryn L, Ghosh, Rajarshi, Hayashi, Emiko, Ishihara, Hisamitsu, Oka, Yoshitomo, Permutt, M Alan, Urano, Fumihiko

“…Wolfram syndrome is an autosomal-recessive disorder characterized by insulin-dependent diabetes mellitus, caused by nonautoimmune loss of beta cells, and…”
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Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1 by Lipson, Kathryn L., Fonseca, Sonya G., Ishigaki, Shinsuke, Nguyen, Linh X., Foss, Elizabeth, Bortell, Rita, Rossini, Aldo A., Urano, Fumihiko

“…In pancreatic β cells, the endoplasmic reticulum (ER) is an important site for insulin biosynthesis and the folding of newly synthesized proinsulin. Here, we…”
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Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion by Fonseca, Sonya G., Urano, Fumihiko, Weir, Gordon C., Gromada, Jesper, Burcin, Mark

“…Persistent ER stress in pancreatic β-cells contributes to the pathogenesis of type 2 diabetes. Fonseca and colleagues show that the ER membrane glycoprotein…”
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Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94 by Kakiuchi, Chihiro, Ishigaki, Shinsuke, Oslowski, Christine M, Fonseca, Sonya G, Kato, Tadafumi, Urano, Fumihiko

“…Valproate is a standard treatment for bipolar disorder and a first-line mood stabilizer. The molecular mechanisms underlying its actions in bipolar disorder…”
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WFS1 Is a Novel Component of the Unfolded Protein Response and Maintains Homeostasis of the Endoplasmic Reticulum in Pancreatic β-Cells by Fonseca, Sonya G., Fukuma, Mariko, Lipson, Kathryn L., Nguyen, Linh X., Allen, Jenny R., Oka, Yoshitomo, Urano, Fumihiko

“…In Wolfram syndrome, a rare form of juvenile diabetes, pancreatic β-cell death is not accompanied by an autoimmune response. Although it has been reported that…”
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Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion by Fonseca, Sonya G, Urano, Fumihiko, Weir, Gordon C, Gromada, Jesper, Burcin, Mark

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The pancreatic ductal epithelium serves as a potential pool of progenitor cells by Bonner-Weir, Susan, Toschi, Elena, Inada, Akari, Reitz, Petra, Fonseca, Sonya Y., Aye, Tandy, Sharma, Arun

“…:  With the increasing success of islet transplantation, β‐cell replacement therapy has had renewed interest. To make such a therapy available to more than a…”
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RETRACTION: Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion by Fonseca, Sonya G, Urano, Fumihiko, Weir, Gordon C, Gromada, Jesper, Burcin, Mark

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Insulin Stimulates Membrane Fusion and GLUT4 Accumulation in Clathrin Coats on Adipocyte Plasma Membranes by Huang, Shaohui, Lifshitz, Larry M., Jones, Christine, Bellve, Karl D., Standley, Clive, Fonseca, Sonya, Corvera, Silvia, Fogarty, Kevin E., Czech, Michael P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Endoplasmic reticulum stress signaling in pancreatic beta-cells by Fonseca, Sonya G, Lipson, Kathryn L, Urano, Fumihiko

“…Pancreatic beta-cells are specialized for the production and regulated secretion of insulin to control blood-glucose levels. Increasing evidence indicates that…”
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Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes by Lipson, Kathryn L, Fonseca, Sonya G, Urano, Fumihiko

“…Increasing evidence suggests that stress signaling pathways emanating from the endoplasmic reticulum (ER) are important to the pathogenesis of both type 1 and…”
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Stress hypERactivation in the β-cell by Fonseca, Sonya G., Urano, Fumihiko, Burcin, Mark, Gromada, Jesper

“…In pancreatic β-cells, the endoplasmic reticulum (ER) is the crucial site for insulin biosynthesis, as this is where the protein-folding machinery for…”
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Retraction Note: Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion by Fonseca, Sonya G., Urano, Fumihiko, Weir, Gordon C., Gromada, Jesper, Burcin, Mark

“…Nat. Cell Biol. 14, 1105–1112 (2012); published online 16 September 2012; retracted online 23 December 2014 Our Letter reported that WFS1 modulates insulin…”
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Correction: Retraction: Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion by Fonseca, Sonya G., Urano, Fumihiko, Weir, Gordon C., Gromada, Jesper, Burcin, Mark

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Timing and expression pattern of carbonic anhydrase II in pancreas by Inada, Akari, Nienaber, Cameron, Fonseca, Sonya, Bonner‐Weir, Susan

“…In the search for genetic markers for assessing the role of duct cells in pancreas growth, we examined whether carbonic anhydrase II (CAII) has ductal cell…”
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AATF mediates anti-apoptotic effect of the unfolded protein response through transcriptional regulation of AKT1 by Ishigaki, Shinsuke, Fonseca, Sonya G., Oslowski, Christine M., Jurczyk, Agata, Shearstone, Jeffrey R., Zhu, Lihua J., Permutt, M. Alan, Greiner, Dale L., Bortell, Rita, Urano, Fumihiko

“…Endoplasmic reticulum (ER) stress-mediated cell death plays an important role in the pathogenesis of chronic diseases including diabetes and neurodegeneration…”
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Total Internal Reflection Fluorescence Microscopy Reveals Insulin RegulatiOn of GluT4 Vesicular Trafficking near the Plasma Membrane of 3T3-L1 Adipocyte by Huang, Shaohui, Fonseca, Sonya, stanley, Clive, Bellve, Karl D

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WFS1 Is a Novel Component of the Unfolded Protein Response and Maintains Homeostasis of the Endoplasmic Reticulum in Pancreatic β-Cells by Sonya G. Fonseca, Mariko Fukuma, Kathryn L. Lipson, Linh X. Nguyen, Jenny R. Allen, Yoshitomo Oka, Fumihiko Urano

“…In Wolfram syndrome, a rare form of juvenile diabetes, pancreatic β-cell death is not accompanied by an autoimmune response. Although it has been reported…”
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