A comprehensive review of therapeutic approaches available for the treatment of cholera

A comprehensive review of therapeutic approaches available for the treatment of cholera

Objectives The oral rehydration solution is the most efficient method to treat cholera; however, it does not interfere in the action mechanism of the main virulence factor produced by Vibrio cholerae, the cholera toxin (CT), and this disease still stands out as a problem for human health worldwide....

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Bibliographic Details
Published in:Journal of pharmacy and pharmacology Vol. 72; no. 12; pp. 1715 - 1731
Main Authors: Sousa, Francisca B. M., Nolêto, Isabela R. S. G., Chaves, Leticia S., Pacheco, Gabriella, Oliveira, Ana P., Fonseca, Mikhail M. V., Medeiros, Jand V. R.
Format: Journal Article
Language:English
Published: Bognor Regis Wiley Subscription Services, Inc 01-12-2020
Subjects:
AMP
Cholera
Cholera toxin
Cystic fibrosis
Diarrhea
Ganglioside GM1
Hydrolase
Kinases
molecular mechanism
Molecular modelling
Neprilysin
Protein kinase
Rehydration
Virulence
Virulence factors
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Summary:Objectives The oral rehydration solution is the most efficient method to treat cholera; however, it does not interfere in the action mechanism of the main virulence factor produced by Vibrio cholerae, the cholera toxin (CT), and this disease still stands out as a problem for human health worldwide. This review aimed to describe therapeutic alternatives available in the literature, especially those related to the search for molecules acting upon the physiopathology of cholera. Key findings New molecules have offered a protection effect against diarrhoea induced by CT or even by infection from V. cholerae. The receptor regulator cystic fibrosis channel transmembrane (CFTR), monosialoganglioside (GM1), enkephalinase, AMP‐activated protein kinase (AMPK), inhibitors of expression of virulence factors and activators of ADP‐ribosylarginine hydrolase are the main therapeutic targets studied. Many of these molecules or extracts still present unclear action mechanisms. Conclusions Knowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0022-3573
2042-7158
DOI:10.1111/jphp.13344