Search Results - "Fonseca, Leonardo G"
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Radiological response to nivolumab in patients with hepatocellular carcinoma: A multicenter analysis of real-life practice
Published in European journal of radiology (01-02-2021)“…•Imaging findings at different timepoints for HCC treated with nivolumab vary between patients and within patients.•The possibility of pseudoprogression must…”
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Return to work after breast cancer diagnosis: An observational prospective study in Brazil
Published in Cancer (15-12-2018)“…Background In North America and Europe, return‐to‐work (RTW) rates vary among breast cancer (BC) survivors, from 24% to 66% and from 53% to 82% at 6 and 36…”
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Insights into the success and failure of systemic therapy for hepatocellular carcinoma
Published in Nature reviews. Gastroenterology & hepatology (01-10-2019)“…Systemic treatment for hepatocellular carcinoma (HCC) has been boosted by the incorporation of new agents after many negative phase III trials in the decade…”
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Early diarrhoea under sorafenib as a marker to consider the early migration to second‐line drugs
Published in United European gastroenterology journal (01-07-2021)“…Background Despite atezolizumab and bevacizumab (A + B) is currently the first‐line treatment for hepatocellular carcinoma (HCC) patients, some patients will…”
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Brazilian Landscape of Hepatocellular Carcinoma
Published in JCO global oncology (01-06-2023)“…The incidence of hepatocellular carcinoma (HCC) is expected to increase in the coming years, and strategies to mitigate the burden of this disease are needed…”
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Efficacy and safety of sorafenib in elderly patients with advanced hepatocellular carcinoma
Published in Clinics (São Paulo, Brazil) (2021)“…To evaluate the efficacy and safety of sorafenib in elderly patients with advanced hepatocellular carcinoma (HCC). We analyzed data from a cohort of patients…”
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Controversies in the management of hepatocellular carcinoma
Published in JHEP reports (01-05-2019)“…The management of hepatocellular carcinoma (HCC) has evolved considerably over the last decade. Surveillance of cirrhotic patients and refinements to imaging…”
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Circulating Tumor DNA Detection in the Management of Anti-EGFR Therapy for Advanced Colorectal Cancer
Published in Frontiers in oncology (22-03-2019)“…Anti-EGFR antibodies are a standard care for advanced -wild type colorectal cancers. Circulating tumor DNA (ctDNA) monitoring during therapy can detect…”
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Tyrosine Kinase Inhibitors and Hepatocellular Carcinoma
Published in Clinics in liver disease (01-11-2020)“…Sorafenib was the first tyrosine kinase inhibitor (TKI) that showed success in extending survival in patients with advanced hepatocellular carcinoma (HCC). In…”
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Low Baseline Plasma L-Glutamine Concentration Identifies Hepatocellular Carcinoma Patients at High Risk of Developing Early Gastrointestinal Adverse Events during Sorafenib Treatment
Published in Gastrointestinal disorders (Basel, Switzerland) (01-07-2022)“…Gastrointestinal adverse events (GIAEs) are common in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. Diarrhea is a prevalent…”
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Response to Paclitaxel in an Adult Patient with Advanced Kaposiform Hemangioendothelioma
Published in Case reports in oncology (24-08-2016)“…Background: Kaposiform hemangioendothelioma (KHE) is a rare neoplasm of vascular origin that typically arises from the skin or soft tissues as a solitary…”
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The complexity of cholangiocarcinoma goes beyond clinical practice: Challenges in trials design and interpretation
Published in Liver international (01-02-2022)Get full text
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Increasing alternatives in systemic treatment for hepatocellular carcinoma: Will algorithms be understandable?
Published in Liver international (01-08-2020)Get full text
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Adherence and quality are key for a beneficial HCC surveillance
Published in Liver international (01-04-2020)Get full text
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Thermal Ablation for Intrahepatic Cholangiocarcinoma in Cirrhosis: Safety and Efficacy in Non-Surgical Patients
Published in Journal of vascular and interventional radiology (01-05-2020)“…To assess the effectiveness, safety, and overall survival (OS) of thermal ablation as upfront treatment of intrahepatic colangiocarcinoma (ICC) in patients…”
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Carbon‐ion radiotherapy for HCC—A potential tool to fulfil an unmet gap in the treatment algorithms?
Published in Liver international (01-12-2018)“…See Article on Page 2239…”
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Activity and safety of sunitinib in poor risk metastatic renal cell carcinoma patients
Published in International Brazilian Journal of Urology (01-12-2014)“…To assess the activity, safety and treatment patterns of sunitinib in patients with poor-risk metastatic renal cell carcinoma (mRCC). We retrospectively…”
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The alpha and ßeta in phase II trials hepatocellular carcinoma ‐ A tale of more than radiological response?
Published in Liver international (01-08-2019)“…See Article on Page 1468…”
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Systemic therapy for hepatocellular carcinoma: trial enrichment does not guarantee success
Published in Oncotarget (18-09-2018)Get full text
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Review on TAS-102 development and its use for metastatic colorectal cancer
Published in Critical reviews in oncology/hematology (01-08-2016)“…Highlights • Trifluridine, a fluoropyrimidine, had previously had its clinical development halted due to its rapid degradation by thymidine phosphorylase. •…”
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