Influence of a lipophilic drug on the stability of emulsions: An important approach on the development of lipidic carriers

The aim of this work was to investigate the influence of a lipophilic drug, Ibuprofen, on the stability of o/w emulsions. Five formulations were prepared by the phase inversion temperature (PIT) method, and Ibuprofen was incorporated into their oil phase. Emulsion stability was evaluated by short- a...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 344; no. 1; pp. 158 - 160
Main Authors:	Formiga, F.R., Fonseca, I.A.A., Souza, K.B., Silva, A.K.A., Macedo, J.P.F., Araújo, I.B., Soares, L.A.L., Egito, E. Socrates T.
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Amsterdam Elsevier B.V 01-11-2007 Elsevier
Subjects:	Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Biological and medical sciences Drug Carriers - chemistry Drug Stability Emulsifying Agents - chemistry Emulsions Emulsions - chemistry General pharmacology HLB Hydrogen-Ion Concentration Ibuprofen Ibuprofen - administration & dosage Ibuprofen - chemistry Lipophilic drugs Medical sciences Mineral Oil - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rheology Stability Water - chemistry Emulsions Stability Lipophilic drugs Ibuprofen HLB Prostaglandin-endoperoxide synthase Pharmaceutical technology Enzyme Enzyme inhibitor Non steroidal antiinflammatory agent Lipophilic compound Emulsion Arylpropionic acid derivatives Oxidoreductases Physicochemical properties
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Summary:	The aim of this work was to investigate the influence of a lipophilic drug, Ibuprofen, on the stability of o/w emulsions. Five formulations were prepared by the phase inversion temperature (PIT) method, and Ibuprofen was incorporated into their oil phase. Emulsion stability was evaluated by short- and long-term studies. Concerning the former, stability under centrifugation showed an improved profile for Ibuprofen-loaded emulsions. The latter confirmed such findings. In conclusion, a rather resistant interfacial film may take place when Ibuprofen was incorporated into the emulsions. Therefore, the critical hydrophilic–lipophilic-balance (HLB) of o/w emulsions can be affected by a lipophilic drug into their oil phase. Such approach is of great importance on the development of lipid carriers for therapeutic drug targeting.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2007.05.052