Search Results - "Fong, Tung Ming"

Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345 by Ming Fong, Tung, Cascieri, Margaret A, Yu, Hong, Bansal, Alka, Swain, Christopher, Strader, Catherine D

“…Substance P is a peptide neurotransmitter that binds to the neurokinin-1 receptor and is involved in pain transmission and neurogenic inflammation. Recently, a…”
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The extracellular domain of the neurokinin-1 receptor is required for high-affinity binding of peptides by Fong, Tung Ming, Yu, Hong, Huang, Ruey Ruey C, Strader, Catherine D

“…The neurokinin-1 receptor binds neurokinin peptides with the potency order of substance P > substance K > neurokinin B. Elucidating the molecular basis of…”
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A Role for the Melanocortin 4 Receptor in Sexual Function by Lex H. T. Van der Ploeg, Martin, William J., Howard, Andrew D., Nargund, Ravi P., Austin, Christopher P., Guan, Xiaoming, Drisko, Jennifer, Cashen, Doreen, Sebhat, Iyassu, Patchett, Arthur A., Figueroa, David J., DiLella, Anthony G., Connolly, Brett M., Weinberg, David H., Tan, Carina P., Palyha, Oksana C., Pong, Sheng-Shung, MacNeil, Tanya, Rosenblum, Charles, Vongs, Aurawan, Tang, Rui, Yu, Hong, Sailer, Andreas W., Fong, Tung Ming, Huang, Cathy, Tota, Michael R., Chang, Ray S., Stearns, Ralph, Tamvakopoulos, Constantin, Christ, George, Drazen, Deborah L., Spar, Brian D., Nelson, Randy J., MacIntyre, D. Euan

“…By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of…”
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The family of G-protein-coupled receptors by Strader, C D, Fong, T M, Graziano, M P, Tota, M R

“…The family of G-protein-coupled receptors can be defined by their similar structural and functional characteristics. Although their primary sequences are quite…”
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ART (Protein Product of Agouti-Related Transcript) as an Antagonist of MC-3 and MC-4 Receptors by Fong, Tung Ming, Mao, Cheri, MacNeil, Tanya, Kalyani, Rubana, Smith, Tim, Weinberg, David, Tota, Michael R., Van der Ploeg, Lex H.T.

“…The mRNA encoding an agouti related protein (ART) of unknown biochemical function was previously reported to be up-regulated in the hypothalamus of two…”
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Localization of leptin binding domain in the leptin receptor by Fong, T M, Huang, R R, Tota, M R, Mao, C, Smith, T, Varnerin, J, Karpitskiy, V V, Krause, J E, Van der Ploeg, L H

“…The leptin receptor is a member of the class I cytokine receptor family and is involved in the control of appetite and body weight. The predicted amino acid…”
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Design and synthesis of (ant)-agonists that alter appetite and adiposity by Van der Ploeg, Lex H T, Kanatani, Akio, MacNeil, Douglas, Ming Fong, Tung, Strack, Alison, Nargund, Ravi, Guan, Xiao-Ming

“…Over the past decade, hypothalamic circuits have been described that impact energy homeostasis in rodents and humans. Our drug development efforts for the…”
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Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor by TUNG MING FONG, HUANG, R.-R. C, STRADER, C. D

“…To identify the molecular determinants of ligand-receptor interactions, the extracellular domain of the human neurokinin-1 receptor was systematically…”
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Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor by Fong, T M, Anderson, S A, Yu, H, Huang, R R, Strader, C D

“…Two isoforms of the human neurokinin-1 receptor were cloned and characterized in heterologous expression systems of mammalian cell culture and Xenopus oocytes…”
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Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580 by TUNG MING FONG, HONG YU, STRADER, C. D

“…Two non-peptide substance P antagonists exhibit opposite rank orders of potency for the human and rat neurokinin-1 receptors. CP-96,345 shows selectivity for…”
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Interaction of Substance P with the Second and Seventh Transmembrane Domains of the Neurokinin-1 Receptor by Huang, Ruey Ruey C, Yu, Hong, Strader, Catherine D, Fong, Tung Ming

“…The neurokinin-1 receptor is a member of the G-protein-coupled receptor family and has the highest affinity for the endogenous peptide transmitter substance P…”
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Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor by Cascieri, M A, Ber, E, Fong, T M, Sadowski, S, Bansal, A, Swain, C, Seward, E, Frances, B, Burns, D, Strader, C D

“…We have synthesized a potent, selective, radioiodinated antagonist of the human neurokinin-1 (NK1) receptor and have characterized its binding to the cloned…”
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A melanocortin agonist reduces neuronal firing rate in rat hypothalamic slices by Fong, Tung Ming, Van der Ploeg, Lex H.T

“…Bath application of α-melanocyte stimulating hormone ( α-MSH) to rat hypothalamic slices inhibited the spontaneous firing rate of continuously firing neurons…”
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Mechanistic hypotheses for the activation of G-protein-coupled receptors by Fong, T M

“…G-protein-coupled receptors (GPCR) play an important role in the functioning of the nervous and endocrine systems. Intensive efforts devoted to mutational…”
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Correlation between acetylcholine receptor function and structural properties of membranes by Fong, Tung Ming, McNamee, Mark G

“…Protein-lipid interactions were studied by using Torpedo californica acetylcholine receptor (AChR) as a model system by reconstituting purified AChR into…”
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Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor by CASCIERI, M. A, MACLEOD, A. M, TUNG MING FONG, UNDERWOOD, D, LIN-LIN SHIAO, BER, E, SADOWSKI, S, HONG YU, MERCHANT, K. J, SWAIN, C. J, STRADER, C. D

“…We have recently shown that a series of N-acyl-L-tryptophan benzyl esters are potent substance P antagonists (Macleod, A. M., Merchant, K. J., Cascieri, M. A.,…”
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Determination of the amino acid residues in substance P conferring selectivity and specificity for the rat neurokinin receptors by Cascieri, M A, Huang, R R, Fong, T M, Cheung, A H, Sadowski, S, Ber, E, Strader, C D

“…We have measured the affinity of various analogs and fragments of the tachykinin substance P for the cloned rat NK1, NK2, and NK3 receptors heterologously…”
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The role of histidine 265 in antagonist binding to the neurokinin-1 receptor by TUNG MING FONG, HONG YU, CASCIERI, M. A, UNDERWOOD, D, SWAIN, C. J, STRADER, C. D

“…Previous studies suggested that the antagonist binding site in the neurokinin-1 receptor is composed of phylogenetically conserved residues, while…”
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Receptor states and modelling by Fong, Tung Ming

“…The difference between microscopic properties and microscopic, experimentally measurable parameters…”
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Stabilization of acetylcholine receptor secondary structure by cholesterol and negatively charged phospholipids in membranes by Fong, Tung Ming, McNamee, Mark G.

“…Fourier-transform infrared (FTIR) spectroscopy was used to study the secondary structure of purified Torpedo californica nicotinic acetylcholine receptor…”
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